Immune responses in the absence of costimulation: viruses know the trick.
J Immunol
; 161(11): 5791-4, 1998 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-9834052
ABSTRACT
Costimulatory molecules are crucial for the induction of immune responses after immunization with purified proteins or peptides. However, some viruses and other pathogens are able to induce protective immunity in the absence of such molecules. This review argues that patterns recognized by both the specific and the innate immune system, together with a high and sustained Ag-load, are responsible for these surprisingly efficient immune responses triggered by pathogens.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus
/
Ativação Linfocitária
/
Anticorpos Antivirais
Limite:
Animals
Idioma:
En
Revista:
J Immunol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Suíça