Adrenal steroid-secreting cells express endothelin-1.
Endocr Res
; 24(3-4): 743-7, 1998.
Article
em En
| MEDLINE
| ID: mdl-9888570
ABSTRACT
Endothelin-1 (ET-1) is involved in adrenal steroid secretion but its cell origin remains unclear. We showed, using RT-PCR the expression of the mRNAs for preproET-1 and ECE-1 in primary cultures of human adrenal cells enriched in glomerulosa cells. Since these expressions could be due to contamination of steroid secreting cells by other cells, we also used the human adrenocortical cell line H295R, which was shown to produce steroids. This cell line also expressed preproET-1-RNA and released mature ET. Functional ET receptors were shown on H295R and cultured human adrenocortical cells. These findings indicate that adrenal steroid-secreting cells synthesize and release ET-1, raising the possibility for an autocrine-paracrine effect of ET-1 on adrenocortical functions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Suprarrenal
/
Corticosteroides
/
Endotelina-1
Limite:
Humans
Idioma:
En
Revista:
Endocr Res
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
França