A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer.
Cancer Res
; 59(1): 35-43, 1999 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-9892180
ABSTRACT
A novel putative tumor suppressor gene and member of the NF2/ERM/ 4.1 superfamily was isolated using Differential Display PCR (DDPCR) on primary lung tumors. When reintroduced into nonexpressing non-small cell lung carcinoma cell lines, this gene, named DAL-1 (for Differentially expressed in Adenocarcinoma of the Lung), was shown to suppress growth. In addition, significantly reduced expression (>50%) of DAL-1 was measured in 39 primary non-small cell lung carcinoma tumors as compared with patient-matched normal lung tissue. Immunocytochemical staining with a polyclonal anti-DAL-1 antibody localized the protein to the plasma membrane, particularly at cell-cell contact points, a pattern reminiscent of other members of the protein 4.1 superfamily including ezrin and NF2. The data suggest DAL-1 is a novel membrane-associated protein with potential to play an important role in the origin and progression of lung cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeos
/
Regulação Neoplásica da Expressão Gênica
/
Genes Supressores de Tumor
/
Carcinoma Pulmonar de Células não Pequenas
/
Proteínas do Citoesqueleto
/
Proteínas Supressoras de Tumor
/
Neoplasias Pulmonares
/
Proteínas de Membrana
Limite:
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos