One hundred and six cases of skeletal tuberculosis seen in the University College Hospital of the West Indies have been reviewed The disease often has an acute onset, but if this is survived, the progress is remarkably slow and the prognosis slow. Treatment is therefore primarily conservative, operation being employed only for stabilisation, correction of deformity, or drainage of abscesses. However, direct attack on the diseased vertabral body has been done in paraplegics, with remarkably satisfactory results. Advanced disease of the hip joint may also be treated by curettage of the lesion itself, combined with corrective osteonomy. The importance of early diagnosis has been emphasized. Deformity and disability can be prevented by starting treatment early in the course of the disease. (Summary).