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Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages.

Tsiamantas, Christos; Kwon, Sunbum; Rogers, Joseph M; Douat, Céline; Huc, Ivan; Suga, Hiroaki.
Angew Chem Int Ed Engl; 2020 Jan 02.
Article in En | MEDLINE | ID: mdl-31894626
Derivatives of 4-aminomethyl-l-phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C-terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.