Comparison of university students who experienced the death of a parent and those who did not in terms of self-compassion and difficulty in emotion regulation.

Against a background of scarce research into the relationship between difficulty in emotion regulation and self-compassion among bereaved populations, the aim of this study was to examine self-compassion and difficulty in emotion regulation among university students who had experienced the death of a parent (n = 150) and those who had not (n = 474). It was found that the self-compassion scores of the university students with a deceased parent were significantly lower than the scores of those with living parents. Similarly, university students whose parent had passed away had higher scores for difficulty in emotion regulation than students who had not lived through that trauma. Our results show that for university students losing a parent may be associated with less self-compassion and more difficulties in emotion regulation.

Semicarbazides Carrying Indole Core: Synthesis, Cytotoxicity Evaluation against Human Breast Cancer Cell Lines, and Molecular Modeling Studies.

In this article, we report the synthesis and cytotoxicity evaluation of novel indole-carrying semicarbazide derivatives (IS1-IS15). The target molecules were obtained by the reaction of aryl/alkyl isocyanates with 1H-indole-2-carbohydrazide that was in-house synthesized from 1H-indole-2-carboxylic acid. Following structural characterization by 1 H-NMR, 13 C-NMR, and HR-MS, IS1-IS15 were investigated for their cytotoxic activity against human breast cancer cell lines, MCF-7 and MDA-MB-231. According to the data obtained from the MTT assay, phenyl ring with a lipophilic group at its para-position and alkyl moiety were preferential substituents on the indole-semicarbazide scaffold for antiproliferative activity. The effect of IS12 (N-(4-chloro-3-(trifluoromethyl)phenyl)-2-(1H-indole-2-carbonyl)hydrazine-1-carboxamide), the compound that demonstrated remarkable antiproliferative activity on both cell lines, was also evaluated on the apoptotic pathway. Moreover, the calculation of critical descriptors constituting drug-likeness confirmed the position of the selected compounds in the anticancer drug development process. Finally, molecular docking studies suggested the inhibition of tubulin polymerization as the potential activity mechanism of this class of molecules.