Impact of Immunonutrition on Nutritional Status in Patients Undergoing Colorectal Cancer Surgery: A Randomized Controlled Clinical Trial.

This study aimed to investigate the additional effects of perioperative immunonutrition (IMN) compared with preoperative immunonutrition (IMN) on anthropometric, nutritional, and biochemical parameters, hospital stay and postoperative complications in patients with colorectal cancer. Oral supplementation enriched with arginine, omega-3 fatty acids, and dietary nucleotides was given to 25 patients before and after the operation (Group 2); 25 patients received the same formula before surgery and standard isocaloric nutrition following the operation (Group 1). Postoperative body weight, body mass index (BMI), and middle upper arm circumference (MUAC) of Group 1 decreased more than Group 2 during follow-up (p < 0.05). The biochemical parameters, C-reactive protein (CRP), aspartate aminotransferase (AST) and fasting plasma glucose (FPG) were higher, and albumin was lower than the baseline in Group 1 compared to Group 2 (p < 0.05). There was a negative correlation between CRP and Nutrition Risk Screening (NRS) 2002 scores, and prealbumin and NRS 2002 scores had a positive correlation (p = 0.007, r = 0.384; p = 0.012, r = 0.352). There was no difference in hospital stay and postoperative complications between the groups (p > 0.05). Perioperative immunonutrition, compared to preoperative immunonutrition, can be used as a positive and effective approach in improving some anthropometric measurements and biochemical parameters in patients undergoing colorectal cancer surgery.

Pomegranate seed oil alleviates colitis: Therapeutic effects achieved by modulation of oxidative stress and inflammation in a rat model.

Pomegranate seed oil shows positive effects by limiting neutrophil activation and lipid peroxidation through its antioxidant and anti-inflammatory activities. This study evaluated the possible ameliorative effects of pomegranate seed oil, its actions on proinflammatory cytokines, and its antioxidant activity using an acute acetic acid-induced colitis model in rats. 32 male Sprague-Dawley rats were divided into 4 groups: control, colitis, 0.4 ml/kg, and 0.8 ml/kg pomegranate seed oil treatment after colitis. At the end of the experiment, histopathological and biochemical analyses of intestinal tissues and blood were performed. The study revealed that administering different doses of pomegranate seed oil dramatically reduced total oxidant levels, nuclear factor kappa B, proinflammatory cytokines, and myeloperoxidase activity and appreciably reduced colitis injury. These findings suggest that pomegranate seed oil may alleviate colitis symptoms effectively and exert protective effects through antioxidant, anti-inflammatory mechanisms.

A service evaluation study of the impact of ageless policy in a London inner-city early intervention in psychosis service.

BACKGROUND: Schizophreniform disorders tend to have an early onset. Early intervention in psychosis (EIP) services aim to provide early treatment, reduce long-term morbidity and improve social functioning. In 2016, changes to mental health policy in England mandated that the primarily youth-focused model should be extended to an ageless one, to prevent ageism; however, this was without strong research evidence. AIMS AND METHOD: An inner-city London EIP service compared sociodemographic and clinical factors between the under-35 years and over-35 years caseload cohorts utilising the EIP package following the implementation of the ageless policy. RESULTS: Both groups received similar care, despite the younger group having significantly more clinical morbidity and needs. CLINICAL IMPLICATIONS: Our results may indicate that service provisions are being driven by policy rather than clinical needs, potentially diverting resources from younger patients. These findings have important implications for future provision of EIP services and would benefit from further exploration.

The effect of diet and aerobic exercise on Premenstrual Syndrome: Randomized controlled trial / O efeito da dieta e do exercício aeróbio na Síndrome Pré-menstrual: ensaio controlado de modo aleatório

ABSTRACT Objective This study was conducted to determine the effectiveness of aerobic exercise and diet in female students with Premenstrual Syndrome Scale who were studying at the public university. Methods This randomized controlled trial was conducted in a public university in 2018. The population of the study was composed of all female first graders (N=426). The female students were followed-up for two cycles, premenstrual syndrome scale was administered to the students and premenstrual syndrome was found in 43.8% (n=187). However, 106 female students were included in the study divided in three groups (diet, aerobic exercise, control). The diet and aerobic exercise were administered during the three months. Results There was no significant difference in premenstrual syndrome scale mean scores between the post-intervention groups. However, the mean premenstrual syndrome score of the diet and aerobic exercise groups decreased significantly after the intervention. There was a significant difference in visual analogue scale score between the groups after intervention. Besides the students in exercise and diet groups experienced less dysmenorrhea intensity than the control group. Conclusion It was found that diet and aerobic exercise were effective in reducing the symptoms of premenstrual syndrome and dysmenorrhea intensity in female students with premenstrual syndrome.

RESUMO Objetivo Este estudo foi feito para determinar a efetividade do exercício aeróbico e dietéticos em alunos mulheres com Síndrome Pré-Menstrual que estudaram na universidade pública. Métodos Este estudo foi conduzido como um ensaio clínico randomizado controlado na universidade pública EM 2018. A população do estudo foi composta por todas as mulheres de primeiro ano (N=426). As mulheres foram monitoradas durante dois ciclos. A Escala de Síndrome Pré-Menstrual foi administrada nas alunas e, em 43,8%, foi encontrada a Síndrome Pré-Menstrual (n=187). O estudo incluiu 106 mulheres. O estudo foi realizado de forma aleatória e em três grupos (dieta, exercício aeróbico, controle). Dieta e exercícios aeróbicos foram administrados por três meses. Resultados Na intervenção subsequente não houve diferenças significativas nos escores médios da escala Síndrome Pré-Menstrual entre os grupos. No entanto, o escore médio do Síndrome Pré-Menstrual nos grupos de exercícios aeróbicos e dieta diminuiu significativamente após a intervenção. Houve diferença significativa no escore médio da escala visual analógica entre os grupos após a intervenção. Foi determinado que os estudantes dos grupos de exercício e dieta experimentaram menos intensidade de dismenorreia que o grupo do controle. Conclusão Determinou-se que a dieta e o exercício aeróbico eram eficazes em reduzir os sintomas da síndrome pré-menstrual e a intensidade da dismenorreia em estudantes com síndrome pré-menstrual.