Leptin Signaling Could Mediate Hippocampal Decumulation of Beta-Amyloid and Tau Induced by High-Intensity Interval Training in Rats with Type 2 Diabetes.

Leptin (LEP) can cross the blood-brain barrier and facilitate cross-talk between the adipose tissue and central nerve system (CNS). This study aimed to investigate the effect of 8-week high-intensity interval training (HIIT) on the LEP signaling in the hippocampus of rats with type 2 diabetes. 20 rats were randomly divided into four groups: (i) control (Con), (ii) type 2 diabetes (T2D), (iii) exercise (EX), and (iv) type 2 diabetes + exercise (T2D + EX). The rats in the T2D and T2D + EX were fed a high-fat diet for two months, then a single dose of STZ (35 mg/kg) was injected to induce diabetes. The EX and T2D + EX groups performed 4-10 intervals of treadmill running at 80-100% of Vmax. Serum and hippocampal levels of LEP as well as hippocampal levels of LEP receptors (LEP-R), Janus kinase 2 (JAK-2), signal transducer and activator of transcription 3 (STAT-3), activated protein kinase (AMP-K), proxy zoster receptor α (PGC-1α), beta-secretase 1 (BACE1), Beta-Amyloid (Aß), Phosphoinositide 3-kinases (PI3K), protein kinase B (AKT), mammalian target of rapamycin (mTOR), Glycogen Synthase Kinase 3 Beta (GSK3ß), and hyperphosphorylated tau proteins (TAU) were measured. One-way ONOVA and Tukey post-hoc tests were used to analyze the data. Serum and hippocampal levels of LEP as well as hippocampal levels of LEP-R, JAK-2, STAT-3, AMP-K, PGC1α, PI3K, AKT, and mTOR were increased while hippocampal levels of BACE1, GSK3B, TAU, and Aß were decreased in T2D + EX compared with T2D group. Serum LEP and hippocampal levels of LEP, LEP-R, JAK-2, STAT-3, AMP-K, PGC1α, PI3K, AKT, and mTOR were decreased. Conversely hippocampal levels of BACE1, GSK3B, TAU, and Aß were increased in T2D group compared with CON group. HIIT could improve LEP signaling in the hippocampus of rats with type 2 diabetes and decrease the accumulation of Tau and Aß, which may reduce the risk of memory impairments.

The effect of eight weeks beetroot juice supplement on aerobic, anaerobic power, and field performance of soccer players.

The purpose of the study investigated the effect of eight weeks of soccer training with beetroot juice supplement on aerobic power, anaerobic power, and field performance of soccer players. This is experimental research, by the control group in pre and post-test. The statistical population was male soccer players. Forty subjects were randomly divided into four groups including the exercise group (EX) the exercise group with beetroot juice supplement (EX&BRJS) the beetroot juice supplement group (BRJS), and the control group (C). Aerobic power, anaerobic threshold, and respiratory exchange ratio, measured by the gas analyser (Cosmed), anaerobic power (peak, mean power), and fatigue index, by Wingate cycle test (Monark, 839), and field performance by (Bangsbo, field test performance). The statistical methods include the Kolmogorov-Smirnov, Levin, covariance (ANCOVA), and pair comparison with Bonferroni test. The results showed eight weeks' of soccer training with beetroot juice supplement, significantly changed aerobic power, respiratory exchange ratio, anaerobic threshold, anaerobic power, field performance, and fatigue index (P ≤ 0.05). Additionally, in all variables, the paired comparison showed that the EX&BRJS group progressed more than all other condition groups. The soccer athletes may use beetroot juice supplements along with soccer exercises to improve aerobic and anaerobic power and field performance.