1.
Bioorg Med Chem Lett
; 14(13): 3495-9, 2004 Jul 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15177460
RESUMEN
3-(N-Alkyl)aminopropylphosphonic acids are potent agonists of four of the five known sphingosine-1-phosphate (S1P) receptor subtypes.
Asunto(s)
Receptores Acoplados a Proteínas G/agonistas , Receptores de Lisoesfingolípidos/agonistas , Animales , Células CHO , Cricetinae , Humanos , Concentración 50 Inhibidora , Ligandos , Organofosfonatos/síntesis química , Compuestos Organofosforados/síntesis química , Radioisótopos de Fósforo , Relación Estructura-Actividad
2.
Bioorg Med Chem Lett
; 14(12): 3351-5, 2004 Jun 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15149705
RESUMEN
Alteration in lymphocyte trafficking and prevention of graft rejection in rodents observed on exposure to FTY720 (1) or its corresponding phosphate ester 2 can be induced by the systemic administration of potent sphingosine-1-phosphate receptor agonists exemplified by 19. The similar S1P receptor profiles of 2 and 19 coupled with their comparable potency in vivo supports a connection between S1P receptor agonism and immunosuppressive efficacy.