RESUMEN
Chemotherapy extravasation is a rare but severe cutaneous complication associated with administration of intravenous chemotherapy. Extravasation causes serious disability and diminishes the quality of life in patients with cancer undergoing antineoplastic therapy. Treatment of chemotherapy extravasation is not standardized. We report a patient with paclitaxel extravasation who was successfully treated with corticosteroids.
Asunto(s)
Antineoplásicos Fitogénicos , Paclitaxel , Humanos , Paclitaxel/efectos adversos , Antineoplásicos Fitogénicos/efectos adversos , Calidad de Vida , Extravasación de Materiales Terapéuticos y Diagnósticos , PielAsunto(s)
Infecciones por Virus de Epstein-Barr , Linfoma Cutáneo de Células T , Neoplasias Cutáneas , Infecciones por Virus de Epstein-Barr/patología , Humanos , Células Asesinas Naturales/patología , Linfoma Cutáneo de Células T/diagnóstico , Linfoma Cutáneo de Células T/patología , Neoplasias Cutáneas/patología , ÚlceraAsunto(s)
Antiprotozoarios , Cardiomiopatía Dilatada , Leishmaniasis Cutánea , Compuestos Organometálicos , Humanos , Antimoniato de Meglumina/efectos adversos , Cardiomiopatía Dilatada/inducido químicamente , Cardiomiopatía Dilatada/tratamiento farmacológico , Meglumina/efectos adversos , Leishmaniasis Cutánea/diagnóstico , Leishmaniasis Cutánea/tratamiento farmacológicoAsunto(s)
Exantema , Pitiriasis Liquenoide , Niño , Exantema/diagnóstico , Exantema/etiología , Humanos , NecrosisRESUMEN
A 45-year-old obese woman diagnosed with morphea on her leg, presented with a 7-year history of cutaneous depressions on her thigh, chest, and back. She recalled that the lesions followed a three-phase course: edema, hardening, and atrophy. Clinical examination revealed a cutaneous indurated depression localized to the thigh, chest, and the back (Figure 1).
Asunto(s)
Obesidad/complicaciones , Paniculitis/complicaciones , Psoriasis/complicaciones , Esclerodermia Localizada/complicaciones , Insuficiencia Venosa/complicaciones , Femenino , Humanos , Persona de Mediana Edad , Paniculitis/patologíaRESUMEN
Inflammatory Tinea capitis (TC) is a rare form of TC. The aim of this study was to review epidemiological, clinical and mycological profile of inflammatory TC. We present a retrospective study (1999-2010), enrolled all the cases of inflammatory TC observed at a referral hospital in the northern Tunisia. One hundred and twenty-one patients with inflammatory TC, 83 male patients (68.6%) and 38 female patients (31.4%) were enrolled. The mean age was about 8 years. A majority of TC (71.9%) were in patients lesser than 10 years of age. Positive family history and contact with animals were noted in seven and 35 cases respectively. Direct examination was positive in 110 cases (59 ectothrix, 51 endothrix) and positive cultures were obtained in 105 patients (49 Trichophyton violaceum, 31 Microsporum canis, 13 Trichophyton interdigitale complex, 12 Trichophyton verrucosum). Systemic treatment was carried out in 115 patients with griseofulvin, in one with terbinafine. A complete recovery was noted in 88 cases; and persistent alopecia in 28 cases. The inflammatory TC is rare, but more common in rural families. The disease mostly affected male genders (68.6%) and T. violaceum remains the common pathogen of inflammatory TC in northern Tunisia.
Asunto(s)
Tiña del Cuero Cabelludo/epidemiología , Tiña del Cuero Cabelludo/microbiología , Adolescente , Adulto , Distribución por Edad , Antifúngicos/uso terapéutico , Niño , Preescolar , Femenino , Estudios de Seguimiento , Humanos , Lactante , Masculino , Microsporum/crecimiento & desarrollo , Microsporum/aislamiento & purificación , Persona de Mediana Edad , Estudios Retrospectivos , Tiña del Cuero Cabelludo/tratamiento farmacológico , Tiña del Cuero Cabelludo/inmunología , Trichophyton/crecimiento & desarrollo , Trichophyton/aislamiento & purificación , Túnez/epidemiología , Adulto JovenAsunto(s)
Antineoplásicos/efectos adversos , Carcinoma de Células Escamosas/inducido químicamente , Hidroxiurea/efectos adversos , Queratosis Actínica/inducido químicamente , Neoplasias Cutáneas/inducido químicamente , Humanos , Masculino , Persona de Mediana Edad , Policitemia Vera/tratamiento farmacológicoRESUMEN
BACKGROUND: Cutaneous manifestations are the most common extra intestinal manifestations associated with inflammatory bowel disease (IBD). AIM: To assess the epidemio-clinical profile of skin manifestations in IBD. METHODS: A prospective and descriptive study was conducted. We have examined skin, mucosa, hair and nails, of all patients with an IBD during one year. RESULTS: One hundred-ninety-five patients were included. Crohn's disease (CD) was noted in 154 cases (79.8%), ulcerous rectocolitis (UC) in 39 cases (21.2%) and inclassable IBD in 2 cases. Cutaneous manifestations were found in 91% of Crohn's patients and in 92% of UC patients. Granulomatous perianal skin lesions were the main cutaneous manifestations of CD (53%). The most common affected sites were ano-perineal fistulae, perianal and perineal fissures and oedematous and infiltrated perianal and genital plaques. Reactive lesions (Erythema nodosum, Pyoderma gangrenosum, Aphthous stomatitis) were noted in 14 cases. Skin manifestations due to malabsorption were also frequently observed (101 cases: 51.7%).Other dermatoses implicating various mechanisms such as psoriasis, alopecia areata, vitiligo, rosacea, lichen planus, were also noted. Adverse skin manifestations due to treatment (folliculitis, acne, macula-papular rash and DRESS syndrome) were present in 16 cases. CONCLUSION: Our series is characterized by a high frequency of cutaneous manifestations associated to IBD. A better recognition of these skin manifestations by the physician may improve their management.
Asunto(s)
Enfermedades Inflamatorias del Intestino/complicaciones , Enfermedades Inflamatorias del Intestino/epidemiología , Enfermedades de la Piel/epidemiología , Enfermedades de la Piel/etiología , Adulto , Enfermedad de Crohn/complicaciones , Enfermedad de Crohn/epidemiología , Eritema Nudoso/diagnóstico , Eritema Nudoso/epidemiología , Eritema Nudoso/etiología , Femenino , Humanos , Síndromes de Malabsorción/diagnóstico , Síndromes de Malabsorción/epidemiología , Síndromes de Malabsorción/etiología , Masculino , Persona de Mediana Edad , Piodermia Gangrenosa/diagnóstico , Piodermia Gangrenosa/epidemiología , Piodermia Gangrenosa/etiología , Enfermedades de la Piel/diagnóstico , Estomatitis Aftosa/diagnóstico , Estomatitis Aftosa/epidemiología , Estomatitis Aftosa/etiología , Túnez/epidemiología , Adulto JovenRESUMEN
Pemphigus herpetiformis (PH) is a rare form of pemphigus, especially when occurring in childhood. Misdiagnosis is common in this age group. The disease exhibits diverse clinical and histological aspects. Further immunological investigations should be performed in order to make the right diagnosis with a correct management strategy.
RESUMEN
Skin manifestations of sarcoidosis occur in up to 30% of cases, and may be the sentinel sign of the disease, with the skin being sometimes exclusively affected. While this may facilitate an early dermatologic diagnosis, heterogeneity in the cutaneous morphologies of sarcoidosis complicates recognition and affirms its reputation as a "great imitator". Here, we present a case of a verrucous version of sarcoidosis that may be misdiagnosed because it can mimic other inflammatory and neoplastic skin disorders. Although it is a rare variant, its presence should alert clinicians to the likelihood of systemic involvement of cutaneous sarcoidosis.
Asunto(s)
Sarcoidosis/diagnóstico , Enfermedades de la Piel/diagnóstico , Diagnóstico Diferencial , Errores Diagnósticos , Humanos , Masculino , Persona de Mediana Edad , Sarcoidosis/patología , Enfermedades de la Piel/patologíaRESUMEN
Maffucci syndrome is a rare nonhereditary disorder comprising of lymphovascular malformations and multiple enchondromas, which may be associated with several internal malignancies. This report describes a new association of Maffucci syndrome with pedal synovial sarcoma. Our case is also remarkable as lymphangioma circumscriptum is the sole lymphovascular component, which has been rarely reported. The aim of this report is to generate awareness about this rare condition and also highlight the importance of screening for malignancies in this disorder.
Asunto(s)
Encondromatosis/complicaciones , Encondromatosis/diagnóstico , Sarcoma Sinovial/complicaciones , Sarcoma Sinovial/diagnóstico , Humanos , Masculino , Persona de Mediana EdadRESUMEN
BACKGROUND: Alopecia areata (AA) is an autoimmune condition that usually presents as patchy, nonscarring hair loss. Autoimmune disorders and atopy are reported as comorbid conditions. We aimed to investigate the demographics, clinical characteristics, and associations of AA in Tunisian patients. METHODS: Demographic data, pattern of alopecia, age of onset, and associations were evaluated in 204 patients from January 2012 to June 2016. RESULTS: Two hundred and four cases of AA were seen. The male to female ratio was 0.68. The mean age at presentation was 23 years old. Positive family history was noticed in 22.1% of patients. Personal history of atopy was associated with AA in 18.1%. Associated autoimmune diseases were thyroid disorders (12.7%), vitiligo (1.5%), psoriasis (three cases), type 1 diabetes (two cases), autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome (two cases), lichen sclerosus atrophicus (one case), and pemphigus vulgaris (one case). Patchy AA was the most common manifestation (49.5%) followed by alopecia universalis (27.5%), alopecia ophiasis (12.7%), and alopecia totalis (10.3%). Nail changes consisting of pitting, trachyonychia, and longitudinal ridging were reported in 24.8%. AA patterns were more severe in females (P = 0.049). Severe forms showed more persistent disease duration (P = 0.005), earlier onset (P = 0.001), and more recurring episodes (P = 0.002) and were significantly associated with nail involvement (P < 0.001). CONCLUSIONS: Our study aimed to review epidemio-clinical characteristics and comorbid conditions of AA in Tunisian patients. More severe cases with a pejorative value of early-onset AA, long disease duration, and nail involvement were seen in our study.
Asunto(s)
Alopecia Areata/epidemiología , Enfermedades Autoinmunes/epidemiología , Enfermedades de la Uña/epidemiología , Adulto , Edad de Inicio , Alopecia Areata/diagnóstico , Alopecia Areata/inmunología , Enfermedades Autoinmunes/inmunología , Comorbilidad , Femenino , Humanos , Masculino , Enfermedades de la Uña/inmunología , Prevalencia , Estudios Prospectivos , Recurrencia , Factores de Riesgo , Índice de Severidad de la Enfermedad , Factores Sexuales , Factores de Tiempo , Túnez/epidemiología , Adulto JovenRESUMEN
We propose to study the epidemiological aspects of North African psoriasis and determine the cardiovascular comorbidities and addictive behaviors associated with psoriasis. This is a North African case-control study which was conducted over a five year period (October 2008 through August 2013), involving 671 psoriatic patients and 1,242 controls identified in various Algerian, Tunisian and Moroccan university hospitals. For each patient, epidemiological characteristic, addictive behaviors, and cardiovascular pathologies associated with psoriasis were noted. Six hundred and seventy one psoriasis patients and 1,242 controls were included in this study. The average age was 47.24 years and the M/F sex-ratio was 1.11 (354 men and 317 women). Statistical analysis showed that psoriasis patients were more likely to develop addictive behaviors than controls (smoking p<10-5 and alcohol consumption: p < 10-5), together with dyslipidemia (30.1% of patients p < 10-5), obesity (23.8% of patients p < 10-4), hypertension (22.3% of patients p < 10-5), diabetes (21.7% of occurrences p < 10-5) and metabolic syndrome (37.4% of patients p<10-5). The relative risk for developing psoriasis was 1.9 in hypertensive patients, 1.7 in diabetic patients, 3.9 in dyslipidemic patients, 1.8 in obese patients, 2.6 in those with metabolic syndrome, 2.1 in smokers and 2.8 in alcoholics. Our work confirms the high incidence of addictive behaviors and of cardiovascular and metabolic comorbidities during the North-African psoriasis, hence the need for a multidisciplinary comprehensive care based on a guideline suited to the characteristics of North-African psoriatic patients.