1.
Org Biomol Chem
; 21(1): 163-168, 2022 12 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36472096
RESUMEN
Heterocyclisation of tert-butyldimethylsilyl (TBS) protected γ-hydroxy-α,ß-unsaturated ketones catalysed by para-toluenesulfonic acid (p-TSA) to form substituted furans is reported. The reaction proceeds under mild conditions at room temperature in methanol to give a range of furan products (21 examples, up to 98% yield). Mechanistic experiments suggest the reaction proceeds via in situ deprotection followed by catalytic dehydrative heterocyclisation.