RESUMEN
The use of natural polymers for design of dosage form has received considerable attention recently, especially from the safety point of view. Among these polymers, chitosan shows very interesting biological, chemical and physical properties which makes it possible to use chitosan for various pharmaceutical applications. Microcrystalline chitosan (MCCh) is a special multifunctional polymeric material existing in the form of either of gelatinous water dispersion or a powder. Thermal aging of chitosan and chitosan-diclofenac sodium mixture have been studied using low-frequency dielectric measurements. The aging was carried out by annealing in ambient atmosphere in the temperature range between 25 degrees C and 100 degrees C. The dielectric losses in the aged samples proved to decrease by about one order of magnitude. The additional measurements of molecular weight distribution and infrared absorption were also carried out for better understanding of nature of the ageing phenomena. Partial evacuation of water, cross-linking and improvement of structural order may be suggested to be a result of thermal aging of the investigated materials.
Asunto(s)
Antiinflamatorios no Esteroideos/química , Materiales Biocompatibles/química , Quitina/análogos & derivados , Diclofenaco/química , Antiinflamatorios no Esteroideos/administración & dosificación , Materiales Biocompatibles/administración & dosificación , Quitina/administración & dosificación , Quitina/química , Quitosano , Diclofenaco/administración & dosificación , Portadores de Fármacos , Calefacción , Peso Molecular , Espectrofotometría Infrarroja , Análisis Espectral/métodos , Agua/análisisRESUMEN
Drift mobility of charge carriers in p-terphenyl, p-quaterphenyl and tetracene polycrystalline thin films was measured using the classical time-of-flight method. The measurements were carried out both in the atmosphere and in vacuum of the order of 10( - 3) Torr. The mobility measured in the atmosphere is of the order of 10(-4)cm2 V(-1) s(-1) and turns out to be about 1 order of magnitude higher than that measured in vacuum. It is suggested that the hopping transport of charge dominates in the structures investigated. The increase in the mobility for the measurements in the atmosphere probably results from the additional localized states due to water and other atmosphere molecules.