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1.

Perinatal thymic-derived CD8αß-expressing Î³Î´ T cells are innate IFN-Î³ producers that expand in IL-7R-STAT5B-driven neoplasms.

Sumaria, Nital; Fiala, Gina J; Inácio, Daniel; Curado-Avelar, Marta; Cachucho, Ana; Pinheiro, Rúben; Wiesheu, Robert; Kimura, Shunsuke; Courtois, Lucien; Blankenhaus, Birte; Darrigues, Julie; Suske, Tobias; Almeida, Afonso R M; Minguet, Susana; Asnafi, Vahid; Lhermitte, Ludovic; Mullighan, Charles G; Coffelt, Seth B; Moriggl, Richard; Barata, João T; Pennington, Daniel J; Silva-Santos, Bruno.

Nat Immunol ; 2024 May 27.

Artículo en Inglés | MEDLINE | ID: mdl-38802512

2.

Flip the coin: IL-7 and IL-7R in health and disease.

Barata, João T; Durum, Scott K; Seddon, Benedict.

Nat Immunol ; 20(12): 1584-1593, 2019 12.

Artículo en Inglés | MEDLINE | ID: mdl-31745336

3.

INPP5K controls the dynamic structure and signaling of wild-type and mutated, leukemia-associated IL-7 receptors.

Moës, Bastien; Li, Hua; Molina-Ortiz, Patricia; Radermecker, Coraline; Rosu, Adeline; Vande Catsyne, Charles-Andrew; Sayyed, Sufyan Ali; Fontela, João; Duque, Mafalda; Mostafa, Alice; Azzi, Abdelhalim; Barata, João T; Merino, Ramon; Xu, Chenqi; Desmet, Christophe J; Schurmans, Stéphane.

Blood ; 141(14): 1708-1717, 2023 04 06.

Artículo en Inglés | MEDLINE | ID: mdl-36599086

4.

Differential activation of basal and IL-7-induced PI3K/Akt/mTOR and JAK/STAT5 signaling distinguishes pediatric from adult acute lymphoblastic leukemia.

Fernandes, Marta B; Gomes, A Margarida; Oliveira, Mariana L; Caldas, Joana; Lúcio, Paulo; Kim, Rathana; Caye-Eude, Aurélie; Pereira, Filomena; De Sousa, Aida B; De Stefano, Alessia; Follo, Matilde Y; Soares, Maria V; Lacerda, João F; Desterro, Joana; Cavé, Hélène; Clappier, Emmanuelle; Duarte, Ximo; Ribeiro, Patrícia; Barata, João T.

Haematologica ; 2024 Apr 24.

Artículo en Inglés | MEDLINE | ID: mdl-38654666

5.

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma.

Silva, Ana; Almeida, Afonso R M; Cachucho, Ana; Neto, João L; Demeyer, Sofie; de Matos, Mafalda; Hogan, Thea; Li, Yunlei; Meijerink, Jules; Cools, Jan; Grosso, Ana Rita; Seddon, Benedict; Barata, João T.

Blood ; 138(12): 1040-1052, 2021 09 23.

Artículo en Inglés | MEDLINE | ID: mdl-33970999

6.

CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.

Cardoso, Bruno A; Duque, Mafalda; Gírio, Ana; Fragoso, Rita; Oliveira, Mariana L; Allen, James R; Martins, Leila R; Correia, Nádia C; Silveira, André Bortolini; Veloso, Alexandra; Kimura, Shunsuke; Demoen, Lisa; Matthijssens, Filip; Jeha, Sima; Cheng, Cheng; Pui, Ching-Hon; Grosso, Ana R; Neto, João L; De Almeida, Sérgio F; Van Vlieberghe, Pieter; Mullighan, Charles G; Yunes, J Andres; Langenau, David M; Pflumio, Françoise; Barata, João T.

Haematologica ; 2023 Dec 07.

Artículo en Inglés | MEDLINE | ID: mdl-38058200

7.

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma.

De Smedt, Renate; Morscio, Julie; Reunes, Lindy; Roels, Juliette; Bardelli, Valentina; Lintermans, Beatrice; Van Loocke, Wouter; Almeida, Afonso; Cheung, Laurence C; Kotecha, Rishi S; Mansour, Marc R; Uyttebroeck, Anne; Vandenberghe, Peter; La Starza, Roberta; Mecucci, Cristina; Lammens, Tim; Van Roy, Nadine; De Moerloose, Barbara; Barata, João T; Taghon, Tom; Goossens, Steven; Van Vlierberghe, Pieter.

Blood ; 135(19): 1685-1695, 2020 05 07.

Artículo en Inglés | MEDLINE | ID: mdl-32315407

8.

Darwin, MSI2, and relapse in T-ALL.

Barata, João T.

Blood ; 143(4): 294-296, 2024 Jan 25.

Artículo en Inglés | MEDLINE | ID: mdl-38270944

9.

Anatomy of a crime: how IL7R and NRAS join forces to drive T-cell acute lymphoblastic leukemia.

Barata, João T.

Haematologica ; 109(6): 1637-1639, 2024 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-38328861

10.

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia.

Evangelisti, Cecilia; Cappellini, Alessandra; Oliveira, Mariana; Fragoso, Rita; Barata, João T; Bertaina, Alice; Locatelli, Franco; Simioni, Carolina; Neri, Luca M; Chiarini, Francesca; Lonetti, Annalisa; Buontempo, Francesca; Orsini, Ester; Pession, Andrea; Manzoli, Lucia; Martelli, Alberto Maria; Evangelisti, Camilla.

J Cell Physiol ; 233(3): 1796-1811, 2018 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-28777460

11.

Surprise, surprise: STAT5 is not enough to stop the steroids.

Fernandes, Marta B; Barata, João T.

Haematologica ; 108(3): 670-672, 2023 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-35734928

12.

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics.

Gaspar, Diana; Freire, João M; Pacheco, Teresa R; Barata, João T; Castanho, Miguel A R B.

Biochim Biophys Acta ; 1853(2): 308-16, 2015 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-25447543

13.

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events.

Mendes, Rui D; Sarmento, Leonor M; Canté-Barrett, Kirsten; Zuurbier, Linda; Buijs-Gladdines, Jessica G C A M; Póvoa, Vanda; Smits, Willem K; Abecasis, Miguel; Yunes, J Andres; Sonneveld, Edwin; Horstmann, Martin A; Pieters, Rob; Barata, João T; Meijerink, Jules P P.

Blood ; 124(4): 567-78, 2014 Jul 24.

Artículo en Inglés | MEDLINE | ID: mdl-24904117

14.

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity.

Melão, Alice; Spit, Maureen; Cardoso, Bruno A; Barata, João T.

Haematologica ; 101(11): 1368-1379, 2016 11.

Artículo en Inglés | MEDLINE | ID: mdl-27470599

15.

Kinases, tails and more: regulation of PTEN function by phosphorylation.

Fragoso, Rita; Barata, João T.

Methods ; 77-78: 75-81, 2015 May.

Artículo en Inglés | MEDLINE | ID: mdl-25448482

16.

Lymphotoxin-ß receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype.

Fernandes, Mónica T; Ghezzo, Marinella N; Silveira, André B; Kalathur, Ravi K; Póvoa, Vanda; Ribeiro, Ana R; Brandalise, Sílvia R; Dejardin, Emmanuel; Alves, Nuno L; Ghysdael, Jacques; Barata, João T; Yunes, José Andres; dos Santos, Nuno R.

Br J Haematol ; 171(5): 736-51, 2015 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-26456771

17.

IL-7Rα: Mr Hyde's twists and turns.

Barata, João T.

Blood ; 122(26): 4151-2, 2013 Dec 19.

Artículo en Inglés | MEDLINE | ID: mdl-24357705

18.

Reduced BAFF-R and increased TACI expression in common variable immunodeficiency.

Barbosa, Rita R; Silva, Susana L; Silva, Sara P; Melo, Alcinda C; Pereira-Santos, M Conceição; Barata, João T; Hammarström, Lennart; Cascalho, Marília; Sousa, Ana E.

J Clin Immunol ; 34(5): 573-83, 2014 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-24809296

19.

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels.

Gomes, A Margarida; Soares, Maria V D; Ribeiro, Patrícia; Caldas, Joana; Póvoa, Vanda; Martins, Leila R; Melão, Alice; Serra-Caetano, Ana; de Sousa, Aida B; Lacerda, João F; Barata, João T.

Haematologica ; 99(6): 1062-8, 2014 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-24561792

20.

IL-7 and IL-7R in health and disease: An update through COVID times.

Fernandes, Marta B; Barata, João T.

Adv Biol Regul ; 87: 100940, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36503870

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Perinatal thymic-derived CD8αß-expressing Î³Î´ T cells are innate IFN-Î³ producers that expand in IL-7R-STAT5B-driven neoplasms.

Flip the coin: IL-7 and IL-7R in health and disease.

INPP5K controls the dynamic structure and signaling of wild-type and mutated, leukemia-associated IL-7 receptors.

Differential activation of basal and IL-7-induced PI3K/Akt/mTOR and JAK/STAT5 signaling distinguishes pediatric from adult acute lymphoblastic leukemia.

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma.

CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma.

Darwin, MSI2, and relapse in T-ALL.

Anatomy of a crime: how IL7R and NRAS join forces to drive T-cell acute lymphoblastic leukemia.

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia.

Surprise, surprise: STAT5 is not enough to stop the steroids.

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics.

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events.

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity.

Kinases, tails and more: regulation of PTEN function by phosphorylation.

Lymphotoxin-ß receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype.

IL-7Rα: Mr Hyde's twists and turns.

Reduced BAFF-R and increased TACI expression in common variable immunodeficiency.

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels.

IL-7 and IL-7R in health and disease: An update through COVID times.