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1.
Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases.
J Med Chem
; 60(13): 5290-5305, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28613871
2.
Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine.
J Med Chem
; 60(19): 8027-8054, 2017 10 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28834431
3.
From Enzyme to Whole Blood: Sequential Screening Procedure for Identification and Evaluation of p38 MAPK Inhibitors.
Methods Mol Biol
; 1360: 123-48, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26501907
4.
Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.
Cell Chem Biol
; 23(11): 1335-1340, 2016 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-27840070
5.
Tetra-substituted pyridinylimidazoles as dual inhibitors of p38α mitogen-activated protein kinase and c-Jun N-terminal kinase 3 for potential treatment of neurodegenerative diseases.
J Med Chem
; 58(1): 443-56, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25475894
6.
The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.
Chem Biol Drug Des
; 86(4): 531-45, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25589097
7.
Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.
ChemMedChem
; 9(11): 2516-27, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25139757
8.
A p38 substrate-specific MK2-EGFP translocation assay for identification and validation of new p38 inhibitors in living cells: a comprising alternative for acquisition of cellular p38 inhibition data.
PLoS One
; 9(4): e95641, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24743242
9.
Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.
J Med Chem
; 56(1): 241-53, 2013 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-23270382
10.
Correction to Tetra-substituted pyridinylimidazoles as dual inhibitors of p38α mitogen-activated protein kinase and c-Jun N-terminal kinase 3 for potential treatment of neurodegenerative diseases.
J Med Chem
; 58(5): 2567, 2015 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25719747
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