RESUMEN
A 14-year-old boy developed an erythema multiforme-like reaction following Toxicodendron radicans (poison ivy) allergic contact dermatitis three separate times over the course of 3 years. The severity of each erythema multiforme-like reaction corresponded to the severity of the allergic contact dermatitis which preceded it.
RESUMEN
MED12-related disorders represent a spectrum of rare neurodevelopmental disorders causing intellectual disability, dysmorphic features, and other systemic abnormalities. We report a case of a 21-month-old girl with extensive hypopigmentation following Blaschko lines attributed to underlying MED12-related disorder.
Asunto(s)
Hipopigmentación , Discapacidad Intelectual , Trastornos del Neurodesarrollo , Femenino , Humanos , Lactante , Complejo MediadorRESUMEN
Sinus pericranii is a rare vascular anomaly characterized by an abnormal communication between the intra- and extracranial venous systems through a calvarial defect(s). We present three cases of congenital sinus pericranii with facial involvement, emphasizing its cutaneous presentation with diagnostic pitfalls and discuss the multidisciplinary management of this vascular anomaly.
Asunto(s)
Seno Pericraneal , Malformaciones Vasculares , Administración Cutánea , Cara , Humanos , Seno Pericraneal/diagnósticoRESUMEN
The discovery of new genetic determinants of inherited skin disorders has been instrumental to the understanding of epidermal function, differentiation, and renewal. Here, we show that mutations in KDSR (3-ketodihydrosphingosine reductase), encoding an enzyme in the ceramide synthesis pathway, lead to a previously undescribed recessive Mendelian disorder in the progressive symmetric erythrokeratoderma spectrum. This disorder is characterized by severe lesions of thick scaly skin on the face and genitals and thickened, red, and scaly skin on the hands and feet. Although exome sequencing revealed several of the KDSR mutations, we employed genome sequencing to discover a pathogenic 346 kb inversion in multiple probands, and cDNA sequencing and a splicing assay established that two mutations, including a recurrent silent third base change, cause exon skipping. Immunohistochemistry and yeast complementation studies demonstrated that the mutations cause defects in KDSR function. Systemic isotretinoin therapy has achieved nearly complete resolution in the two probands in whom it has been applied, consistent with the effects of retinoic acid on alternative pathways for ceramide generation.
Asunto(s)
Oxidorreductasas de Alcohol/genética , Genes Recesivos , Predisposición Genética a la Enfermedad , Queratosis/enzimología , Queratosis/genética , Mutación/genética , Ceramidas/biosíntesis , Proteínas Filagrina , Prueba de Complementación Genética , Heterocigoto , Humanos , Proteínas de Filamentos Intermediarios/metabolismo , Polimorfismo de Nucleótido Simple/genética , Empalme del ARN/genética , Saccharomyces cerevisiae/metabolismoRESUMEN
It has been clinically speculated that the use of oil for hair grooming may change detection of fungus on culture; however, the effect of hair oil on fungal cultures remains poorly studied. In this prospective case-controlled study, scalp cultures were collected from twenty-eight pediatric patients with clinically suspected tinea capitis before and after cosmetic hair oil was rubbed into the scalp. Following hair oil application, fifteen of the sixteen originally positive patients tested positive, while one patient that had tested negative prior to hair oil had a positive culture. Our study suggests that recent hair oil application has minimal effect on the sensitivity of fungal culture for tinea capitis and we can rely on our standard fungal cultures with or without hair oil.
Asunto(s)
Cuero Cabelludo , Niño , Cabello , Humanos , Estudios Prospectivos , Tiña del Cuero Cabelludo/diagnóstico , Tiña del Cuero Cabelludo/tratamiento farmacológico , TrichophytonRESUMEN
Filaggrin (FLG) loss-of-function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD) and are often population-specific. African-American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atopy health disparity group for which the role of FLG LOF is not well known. Discovery of FLG LOF using exome sequencing is challenging given the known difficulties for accurate short-read alignment to FLG's high homology repeat variation. Here, we employed an array-based sequencing approach to tile across each FLG repeat and discover FLG LOF in a well-characterized cohort of AA children with moderate-to-severe AD. Five FLG LOF were identified in 23% of our cohort. Two novel FLG LOF singletons, c.488delG and p.S3101*, were discovered as well as p.R501*, p.R826* and p.S3316* previously reported for AD. p.S3316* (rs149484917) is likely an African ancestral FLG LOF, reported in African individuals in ExAC (Exome Aggregation Consortium), Exome Variant Server (ESP), and 4 African 1000G population databases (ESN, MSL, ASW, and ACB). The proportion of FLG LOF (11.5%) among the total FLG alleles in our cohort was significantly higher in comparisons with FLG LOF reported for African individuals in ExAC (2.5%; P = 4.3 × 10-4 ) and ESP (1.7%; P = 3.5 × 10-5 ) suggesting a disease-enrichment effect for FLG LOF. Our results demonstrate the utility of array-based sequencing in discovering FLG LOF, including novel and population-specific, which are of higher prevalence in our AA severe AD group than previously reported.
Asunto(s)
Negro o Afroamericano/genética , Dermatitis Atópica/genética , Proteínas de Filamentos Intermediarios/genética , Mutación con Pérdida de Función , Análisis de Secuencia de ADN/métodos , Adolescente , Alelos , Niño , Preescolar , Exoma , Proteínas Filagrina , Humanos , Lactante , Análisis de Secuencia por Matrices de Oligonucleótidos , Índice de Severidad de la EnfermedadRESUMEN
Skin cancer risk is elevated in solid OTRs. Studies of skin cancer awareness and sun-protection behaviors in pOTRs have not been reported. We measured effects over time of a multimodal educational intervention on knowledge of sun-protection practices and skin cancer risk, engagement in sun-protection behaviors, and self-efficacy and perceived barriers to photoprotection in pOTRs, their guardians, and a comparison group of children and guardians. Knowledge about skin cancer risk increased in pOTRs and their guardians (P≤.01) and frequency of pOTRs' sun-protection behaviors reported by pOTRs and their guardians also improved.
Asunto(s)
Trasplante de Órganos , Educación del Paciente como Asunto/métodos , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/diagnóstico , Receptores de Trasplantes , Adolescente , Niño , Femenino , Estudios de Seguimiento , Conductas Relacionadas con la Salud , Conocimientos, Actitudes y Práctica en Salud , Humanos , Masculino , Estudios Prospectivos , Factores de Riesgo , Luz Solar/efectos adversosRESUMEN
Omenn syndrome is an autosomal recessive form of "leaky" severe combined immune deficiency resulting in distinct phenotypic features. The patient described herein had an atypical presentation of Omenn syndrome, with conspicuous erythroderma and extreme lymphocytosis at birth, in contrast to the typical evolution of rash seen during the first few weeks of life. In addition, the skin findings were secondary to infiltration of CD8+ (cytotoxic) T-cells in contrast to the CD4+ (helper) T-cells typically seen, which broadens the Omenn syndrome phenotype.
Asunto(s)
Dermatitis Exfoliativa/diagnóstico , Linfocitosis/diagnóstico , Inmunodeficiencia Combinada Grave/diagnóstico , Piel/patología , Proteínas de Unión al ADN/genética , Dermatitis Exfoliativa/genética , Femenino , Proteínas de Homeodominio/genética , Humanos , Recién Nacido , Linfocitosis/genética , Mutación , Proteínas Nucleares/genética , Inmunodeficiencia Combinada Grave/genéticaRESUMEN
BACKGROUND: Eccrine angiomatous hamartoma (EAH) is a benign cutaneous lesion defined by the proliferation of hamartomatous eccrine and capillary-like vascular elements in the dermis. However, the epidemiologic, morphologic, and histopathologic aspects of this uncommon disorder have yet to be fully delineated. METHODS: The authors retrospectively reviewed 18 EAH cases (including 14 accompanying skin biopsy specimens) diagnosed at 4 American university hospitals from 1996 to 2014. RESULTS: Patients ranged from 3 days to 84 years at time of diagnosis with a median age of 15 years. A male:female ratio of 11:7 was observed. Sixty-seven percent of cases presented in the extremities, but lesions in the trunk and head/neck regions also occurred. Four patients had multiple lesions, and 2 displayed a segmental pattern. Histologically, dermal vascular dilatation and acanthosis often accompanied EAH's typical eccrine and vascular comingling. One individual developed EAH at the site of a recurrent squamous cell carcinoma after previous excision. CONCLUSIONS: Although previously thought to occur primarily as a solitary angiomatous-appearing malformation on the extremities of children, EAH may develop with some frequency in adults and may manifest in a multifocal linear distribution. The authors also raise additional histopathologic consideration in support of the vascular theory of histogenesis for this condition.
Asunto(s)
Glándulas Ecrinas/patología , Hamartoma/patología , Enfermedades de la Piel/patología , Enfermedades de las Glándulas Sudoríparas/patología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Adulto JovenRESUMEN
We report a case of myelodysplastic syndrome (MDS) occurring in an African American boy with Gorlin syndrome with a novel PTCH1 mutation. Before developing MDS, the patient had been treated with chemotherapy and radiation for a medulloblastoma. He received a bone marrow transplant for the MDS and eventually died of treatment complications. Secondary hematologic malignancies are a known complication of certain chemotherapeutics, although whether a patient with Gorlin syndrome has a greater propensity for the development of such malignancies is unclear.
Asunto(s)
Síndrome del Nevo Basocelular/complicaciones , Síndromes Mielodisplásicos/etiología , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Síndrome del Nevo Basocelular/terapia , Trasplante de Médula Ósea , Niño , Resultado Fatal , Humanos , Masculino , Mutación , Síndromes Mielodisplásicos/terapia , Receptor Patched-1/genéticaRESUMEN
Leukemia cutis (LC) denotes a cutaneous infiltration of neoplastic myeloid cells or lymphoid blasts, which can present in the setting of acute myeloid leukemia, particularly in those cases with monocytic or myelomonocytic differentiation. Rarely, cutaneous involvement by a leukemic infiltrate can occur in the absence of bone marrow or peripheral blood involvement by acute leukemia; this then is referred to as aleukemic LC (ALC). Recognition of LC is important for further classification and early diagnosis of the disease, but the diagnosis is difficult in the absence of a systemic presentation of acute leukemia. Although the molecular and cytogenetic features of ALC are poorly characterized, some have shown specific molecular alterations in common with classic forms of acute leukemias. We present 3 cases of ALC in pediatric patients.
Asunto(s)
Infiltración Leucémica/patología , Piel/patología , Adolescente , Niño , Preescolar , Femenino , Humanos , Leucemia Mieloide Aguda/patología , Masculino , Neoplasias Primarias Secundarias/patologíaRESUMEN
Oral and topical ß-blockers are used to treat infantile hemangiomas (IHs). Although a recent consensus report provided guidelines for the treatment of IH with propranolol, there are no standard guidelines for the use of topical timolol. The objectives of this study were to determine the current use of oral propranolol and topical timolol by pediatric dermatologists in an outpatient setting and to compare current propranolol use with published propranolol consensus guidelines. An electronic survey was sent to pediatric dermatologists in May and June 2013. One hundred forty-nine pediatric dermatologists responded to the survey, a 79% response rate. Of the respondents, 96% prescribed oral propranolol, but 75% did not follow consensus guidelines exactly; recommended history, physical examination, initial dose, and frequency varied. The dose of propranolol was usually titrated up to goal dose as recommended (89%). Fifty-six percent monitored vital signs in patients after the initial dose and 49% continued to monitor vital signs in their clinic after each dose escalation, which did not meet consensus guideline recommendations. Ninety-one percent reported using topical timolol for the treatment of IH and 66% responded they had used topical timolol in conjunction with oral propranolol to treat IH. The most common indication was superficial hemangiomas (97%). Most practitioners (74%) did not routinely monitor heart rate or blood pressure in infants treated with topical timolol. This study highlights the variability in prescribing and monitoring practices of physicians using propranolol for the treatment of IHs and demonstrates that topical timolol is commonly used alone and in conjunction with oral propranolol to treat IHs.
Asunto(s)
Hemangioma Capilar/tratamiento farmacológico , Síndromes Neoplásicos Hereditarios/tratamiento farmacológico , Propranolol/uso terapéutico , Neoplasias Cutáneas/tratamiento farmacológico , Encuestas y Cuestionarios , Timolol/uso terapéutico , Administración Oral , Administración Tópica , Atención Ambulatoria/métodos , Atención Ambulatoria/normas , Actitud del Personal de Salud , Preescolar , Consenso , Femenino , Estudios de Seguimiento , Encuestas de Atención de la Salud , Hemangioma Capilar/diagnóstico , Humanos , Lactante , Recién Nacido , Masculino , Síndromes Neoplásicos Hereditarios/diagnóstico , Pacientes Ambulatorios/estadística & datos numéricos , Guías de Práctica Clínica como Asunto , Pautas de la Práctica en Medicina/normas , Medición de Riesgo , Índice de Severidad de la Enfermedad , Neoplasias Cutáneas/diagnóstico , Resultado del TratamientoRESUMEN
Pediatric trachyonychia is an acquired nail disease that can cause distress to families. It is a poorly understood disease, and long-term follow-up data are lacking. We present an institutional review of 11 children with isolated pediatric trachyonychia followed over time. Children with the diagnosis of pediatric trachyonychia were identified and invited to participate. Pictures were taken on follow-up and a questionnaire was answered. Exclusion criteria include having another diagnosis at the initial visit that causes nail dystrophy. Eleven patients with the diagnosis of pediatric trachyonychia were available for follow-up. The mean age of appearance was 2.7 years (range 2-7 yrs) and the average follow-up was 66 months (range 10-126 mos). Nine patients were treated with potent topical corticosteroids, one used only petrolatum, and one took vitamin supplements. One patient was found to have an additional skin and hair diagnosis of alopecia areata on follow-up. On follow-up, 82% noted improvement of the nails, whereas 18% noted no change. A majority of cases of pediatric trachyonychia are isolated and improve with time, regardless of treatment.
Asunto(s)
Enfermedades de la Uña/epidemiología , Enfermedades de la Uña/patología , Administración Tópica , Corticoesteroides/uso terapéutico , Distribución por Edad , Atrofia/patología , Niño , Preescolar , Estudios de Cohortes , Suplementos Dietéticos , Femenino , Estudios de Seguimiento , Humanos , Masculino , Enfermedades de la Uña/tratamiento farmacológico , Pediatría , Vaselina/uso terapéutico , Estudios Retrospectivos , Medición de Riesgo , Índice de Severidad de la Enfermedad , Distribución por Sexo , Factores de Tiempo , Resultado del TratamientoRESUMEN
Previous examination in a small number of individuals with Williams syndrome (also referred to as Williams-Beuren syndrome) has shown subtly softer skin and reduced deposition of elastin, an elastic matrix protein important in tissue recoil. No quantitative information about skin elasticity in individuals with Williams syndrome is available; nor has there been a complete report of dermatologic findings in this population. To fill this knowledge gap, 94 patients with Williams syndrome aged 7-50 years were recruited as part of the skin and vascular elasticity (WS-SAVE) study. They underwent either a clinical dermatologic assessment by trained dermatologists (2010 WSA family meeting) or measurement of biomechanical properties of the skin with the DermaLab™ suction cup (2012 WSA family meeting). Clinical assessment confirmed that soft skin is common in this population (83%), as is premature graying of the hair (80% of those 20 years or older), while wrinkles (92%), and abnormal scarring (33%) were detected in larger than expected proportions. Biomechanical studies detected statistically significant differences in dP (the pressure required to lift the skin), dT (the time required to raise the skin through a prescribed gradient), VE (viscoelasticity), and E (Young's modulus) relative to matched controls. The RT (retraction time) also trended longer but was not significant. The biomechanical differences noted in these patients did not correlate with the presence of vascular defects also attributable to elastin insufficiency (vascular stiffness, hypertension, and arterial stenosis) suggesting the presence of tissue specific modifiers that modulate the impact of elastin insufficiency in each tissue.
Asunto(s)
Piel/patología , Síndrome de Williams/patología , Adolescente , Adulto , Fenómenos Biomecánicos , Estudios de Casos y Controles , Niño , Estudios de Cohortes , Demografía , Familia , Color del Cabello , Humanos , Persona de Mediana Edad , Piel/fisiopatología , Enfermedades Vasculares/patología , Enfermedades Vasculares/fisiopatología , Síndrome de Williams/fisiopatologíaRESUMEN
BACKGROUND: Glomus tumors have recently been reported in individuals with the neurofibromatosis type 1 (NF1) cancer disposition syndrome. We compare the clinical and molecular features of these painful hamartomas in a series of sporadic and NF1-associated cases. OBJECTIVE: We sought to evaluate the association of NF1 with glomus tumors and to compare NF1-associated glomus tumors with sporadic glomus tumors. METHODS: We conducted a retrospective cohort study of all individuals with a histopathologic diagnosis of glomus tumor at a large tertiary care center from January 1998 to January 2013. Charts were reviewed for a coexisting diagnosis of NF1. RESULTS: A total of 42 glomus tumors were identified in 34 individuals. Twelve (28.6%) were found in 6 patients with NF1. In 28 individuals with 30 sporadic tumors, there was no coexisting medical condition. Although multifocal tumors (16.7%) and tumor recurrence (33.3%) were more common in association with NF1, these trends did not reach statistical significance. NF1-associated glomus tumors exhibited no neurofibromin immunoreactivity, whereas their sporadic counterparts retained neurofibromin expression. LIMITATIONS: The retrospective design resulted in incomplete data capture. CONCLUSIONS: Detection of glomus tumors should raise suspicion for a concurrent diagnosis of NF1.
Asunto(s)
Tumor Glómico/complicaciones , Neurofibromatosis 1/complicaciones , Adolescente , Adulto , Anciano , Niño , Femenino , Tumor Glómico/metabolismo , Humanos , Masculino , Persona de Mediana Edad , Neurofibromatosis 1/metabolismo , Neurofibromina 1/metabolismo , Estudios Retrospectivos , Adulto JovenRESUMEN
Primary hyperhidrosis is a common disorder affecting children and adolescents, and it can have a significant negative psychosocial effect. Treatment for pediatric hyperhidrosis tends to be limited by low efficacy, low adherence, and poor tolerance. Oral glycopyrrolate is emerging as a potential second-line treatment option, but experience with safety, efficacy, and dosing is especially limited in children. We present an institutional review of 12 children with severe, refractory hyperhidrosis treated with oral glycopyrrolate; 11 (92%) noted improvement and 9 (75%) would recommend oral glycopyrrolate to their friends. No significant side effects were noted. Our retrospective analysis suggests that oral glycopyrrolate is safe and effective in children with hyperhidrosis.
Asunto(s)
Glicopirrolato/administración & dosificación , Hiperhidrosis/tratamiento farmacológico , Antagonistas Muscarínicos/administración & dosificación , Administración Oral , Adolescente , Niño , Femenino , Humanos , Masculino , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
Scleral infantile hemangiomas are rare. We describe a patient who presented at 3 months of age with an enlarging infantile hemangioma on the sclera of the left eye. He had two other hemangiomas on the left eyebrow and chest. Treatment with propranolol resulted in marked improvement of all of his hemangiomas. He did not develop any ocular complications.
Asunto(s)
Neoplasias del Ojo/tratamiento farmacológico , Neoplasias de los Párpados/tratamiento farmacológico , Hemangioma/tratamiento farmacológico , Propranolol/uso terapéutico , Esclerótica/patología , Neoplasias del Ojo/patología , Neoplasias de los Párpados/patología , Hemangioma/patología , Humanos , Lactante , Masculino , Resultado del Tratamiento , Vasodilatadores/uso terapéuticoRESUMEN
Warts are common and are a challenge to treat in some children, especially immunocompromised children and those who fail or cannot tolerate salicylic acid preparations and cryotherapy. Cidofovir, a nucleotide analogue with antiviral activity, has demonstrated promising results when compounded into a topical form to treat refractory warts. We present a retrospective institutional review of 12 children with refractory verrucae treated with 1% to 3% topical cidofovir compounded in an unscented moisturizing cream, applied every other day to daily. In our institutional series, only three patients (25%) demonstrated complete clearance of their verrucae. An additional four patients (33%) demonstrated partial clearance. Our experience using topical cidofovir has been less successful than previous institutional reviews, possibly because we used a lower concentration and less-frequent dosing. More studies are needed to better characterize the efficacy, safety, and dosing of topical cidofovir for the treatment of refractory warts.
Asunto(s)
Antivirales/uso terapéutico , Citosina/análogos & derivados , Organofosfonatos/uso terapéutico , Enfermedades de la Piel/tratamiento farmacológico , Verrugas/tratamiento farmacológico , Administración Tópica , Adolescente , Niño , Preescolar , Cidofovir , Estudios de Cohortes , Citosina/uso terapéutico , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Femenino , Estudios de Seguimiento , Humanos , Masculino , Estudios Retrospectivos , Medición de Riesgo , Índice de Severidad de la Enfermedad , Enfermedades de la Piel/diagnóstico , Resultado del Tratamiento , Verrugas/diagnósticoRESUMEN
We report a case of focal preauricular dermal dysplasia in an 18-day-old healthy girl. We discuss the classification of focal preauricular dermal dysplasia within the spectrum of focal facial dermal dysplasia and aplasia cutis congenita.
Asunto(s)
Displasia Ectodérmica/clasificación , Cara/patología , Hipoplasia Dérmica Focal/clasificación , Displasia Ectodérmica/diagnóstico , Displasia Ectodérmica/patología , Femenino , Hipoplasia Dérmica Focal/diagnóstico , Displasias Dérmicas Faciales Focales , Humanos , Recién NacidoRESUMEN
Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a severe variant of pityriasis lichenoides et varioliformis acuta (PLEVA). We report a case of FUMHD in an 11-year-old boy who subsequently developed neurologic symptoms and was found to have necrotizing vasculitis on brain biopsy. Over 5 years of follow-up, he had one biopsy-proven recurrence of his skin lesions and continued rehabilitation and treatment for residual neurologic complications. This case provides histological evidence of central nervous system vasculitis associated with FUMHD. Our patient's disease was eventually controlled with cyclophosphamide.