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1.
Vet Comp Orthop Traumatol ; 36(2): 82-86, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-36577447

RESUMEN

OBJECTIVES: The aim of this study was to compare the deflection distance, deflection angle and pre-loading sub-bandage pressure of a transverse, mid-metacarpal fracture in an equine cadaver limb when loaded in bending while stabilized with either a Robert Jones Bandage (RJB) or a single-stack bandage (SS), each containing two orthogonal splints. STUDY DESIGN: In an ex vivo experimental study, forelimb pairs from eight horses were collected, and one forelimb from each pair was assigned to either the SS or RJB groups. A transverse osteotomy was performed at the midpoint of the metacarpus. After bandaging, the limbs were loaded in bending. Pre-loading sub-bandage pressure, pre- and post-loading radiographs and post-loading deflection distance measurements were taken. Dorsopalmar radiographs were used to measure the loaded deflection angle. RESULTS: There was no significant difference between RJB and SS constructs in change in deflection angle (10.7 ± 3.0 degrees vs. 9.8 ± 2.6 degrees; p = 0.5) or deflection distance (13.1 ± 2.6 cm vs. 11.4 ± 3.1 cm; p = 0.2). Sub-bandage pressures were significantly greater for the SS than the RJB both dorsally and laterally. CONCLUSION: The SS splint construct resists bending forces similarly to the RJB splint construct in an ex vivo transverse, metacarpal fracture model. The SS splint construct may be a useful alternative to the RJB splint construct in field situations for metacarpal fracture stabilization.


Asunto(s)
Vendajes , Fracturas Óseas , Huesos del Metacarpo , Animales , Vendajes/normas , Vendajes/veterinaria , Fenómenos Biomecánicos , Miembro Anterior/lesiones , Fracturas Óseas/terapia , Fracturas Óseas/veterinaria , Caballos/lesiones , Huesos del Metacarpo/lesiones , Férulas (Fijadores)/normas , Férulas (Fijadores)/veterinaria
2.
Equine Vet J ; 39(1): 33-6, 2007 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-17228592

RESUMEN

REASONS FOR PERFORMING STUDY: Anecdotal speculation suggests that prognosis for survival of mares and foals following correction of uterine torsion has improved over the past 30 years. OBJECTIVES: To determine statistically the outcome of uterine torsion according to duration of clinical signs, stage of gestation, parity, physical examination findings, method of correction, prognosis for survival and reproductive health of the mare, and prospects for the foal within the neonatal period. METHODS: This retrospective study combined cases from 4 equine referral hospitals. RESULTS: The stage of gestation at which uterine torsion occurred was a risk factor for survival of mare and foal. Overall mare survival was 53/63 (84%); when uterine torsion occurred at < 320 days gestation, 36/37 (97%) of mares survived compared to 17/26 (65%) survival rate when uterine torsion occurred at > or = 320 days gestation. Overall foal survival was 54% (29/54). When uterine torsion occurred at < 320 days gestation, 21/29 (72%) foals survived compared to 8/25 (32%) when uterine torsion occurred at > or = 320 days gestation. Thirty mares were discharged from the hospital carrying a viable fetus following uterine torsion correction and 25/30 (83%) of these mares delivered live foals that survived beyond the neonatal period. CONCLUSIONS: Prognosis for survival for mares and foals following uterine torsion is good and improves if torsion occurs < 320 days compared to > or = 320 days gestation. CLINICAL RELEVANCE: Gestational timing of uterine torsion should be considered when advising clients about the prognosis for survival of the mare and foal. The prognosis for a mare delivering a live foal is good if the mare is discharged from the hospital following uterine torsion correction with a viable fetus.


Asunto(s)
Enfermedades de los Caballos/mortalidad , Complicaciones del Embarazo/veterinaria , Resultado del Embarazo/veterinaria , Enfermedades Uterinas/veterinaria , Animales , Femenino , Edad Gestacional , Enfermedades de los Caballos/patología , Caballos , Embarazo , Complicaciones del Embarazo/mortalidad , Complicaciones del Embarazo/patología , Pronóstico , Estudios Retrospectivos , Análisis de Supervivencia , Anomalía Torsional/veterinaria , Enfermedades Uterinas/complicaciones , Enfermedades Uterinas/mortalidad , Enfermedades Uterinas/patología
4.
Equine Vet J ; 49(3): 329-333, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-27289022

RESUMEN

REASONS FOR PERFORMING STUDY: Currently, there is no objective information quantifying pressures exerted by distal limb bandages. OBJECTIVES: To quantify the pressure exerted by each compression layer, a polo wrap (DLP), a compression bandage (DLC), and to measure the effect of time on sub-bandage pressure. STUDY DESIGN: Longitudinal observational experiment. METHODS: A DLC construct included a cotton roll compressed with brown gauze and elastic layers and the DLP construct included a pillow pad compressed by a cloth wrap. Dorsal and lateral sensors were placed on the mid-metacarpus. In healthy horses, sub-bandage pressures were recorded during application (n = 8) and at scheduled time points over the 24 (n = 9) and 96 h periods (n = 8). A generalised linear model was used to evaluate associations between pressure and sensor location, bandage type and time (P<0.05). RESULTS: For the DLC, dorsal and lateral sensor pressures were 187 mmHg (95% CI 185-189 mmHg) and 142 mmHg (95% CI 133-151 mmHg). Combined sensor pressure after application of the brown gauze was 80 mmHg (95% CI 75-85 mmHg) and rose to 165 mmHg (95% CI 160-170 mmHg) after the elastic layer. Combined pressure at the end of the 96 h period was 135 mmHg (95% CI 123-147 mmHg). For the DLP bandage, location but not time was significant. Combined pressures ranged between 75 mmHg (95% CI 53-97 mmHg) and 85 mmHg (95% CI 63-107 mmHg). CONCLUSIONS: Pressure distribution was not uniform. The DLP pressures were maintained for a 24 h period. The DLC maintained high pressures for 96 h, but a significant decrease in pressure occurred between 6 and 12 h. Providing there are no other reasons to change a bandage, a 4 day interval between bandages may be appropriate if maintaining distal limb compression is the principal indication.


Asunto(s)
Vendajes de Compresión/veterinaria , Caballos , Presión , Animales , Femenino , Miembro Anterior/fisiología , Ensayo de Materiales
5.
Equine Vet J ; 47(5): 599-602, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-25124529

RESUMEN

REASONS FOR PERFORMING STUDY: Clinicians frequently place post operative abdominal bandages on horses undergoing laparotomies. Presently, no information exists on the amount of incisional support provided by these bandages. Determination of sub-bandage pressure provides a means of comparing the ability of different bandages to support incisions. OBJECTIVES: Determination of sub-bandage pressure over a 24 h period using 3 bandaging techniques. STUDY DESIGN: A randomised, crossover design using 9 healthy horses. METHODS: Horses were randomly assigned to a treatment regimen consisting of placement of 3 abdominal bandage types, namely an elastic bandage (ELA), the CM(TM) Hernia Heal Belt (CM) or a nylon binder (NYL). The sub-bandage pressures for each bandage were measured with the Picopress® compression-measuring system at 0, 2, 4, 6, 8, 12, 16, 20 and 24 h after application. RESULTS: No time and treatment interactions were observed, and bandage pressures were maintained within each treatment group over the 24 h period. Mean sub-bandage pressures were different between all treatment groups (P < 0.001) at 39 (95% confidence interval, 36.7-40.5 mmHg), 25 (95% confidence interval, 23.9-27.7 mmHg) and 5 mmHg (95% confidence interval, 4.1-7.8 mmHg) for CM, ELA and NYL bandages, respectively. Horses were more likely to lie down with the CM (P = 0.02) and ELA treatments (P = 0.0002) when compared with the NYL treatment. The ELA bandages were more likely to displace caudally compared with both CM and NYL bandages. CONCLUSIONS: The CM bandage was superior to both ELA and NYL bandages with regard to measured sub-bandage pressure over the 24 h period. The clinical significance of the differences in sub-bandage pressure between treatments cannot be determined by this study.


Asunto(s)
Vendajes , Caballos , Ensayo de Materiales , Presión , Animales , Femenino , Masculino
6.
J Appl Physiol (1985) ; 77(6): 2812-6, 1994 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-7896626

RESUMEN

The effect of transection of the sternothyroideus and sternohyoideus muscles on upper airway mechanics was investigated in exercising horses. Upper airway mechanics of six Standardbred horses were measured at rest and during exercise before and 24 h and 2 wk after sternothyrohyoid myectomy. Transnasal tracheal and pharyngeal catheters connected to differential pressure transducers were used to measure tracheal and pharyngeal pressures. A pneumotachograph mounted on the rostral end of an airtight face mask was used to measure airflow. Horses ran at 50, 75, and 100% of maximal O2 consumption on a treadmill. Twenty-four hours after sternothyrohyoid myectomy, no significant difference was detected in tracheal, pharyngeal, or translaryngeal inspiratory and expiratory pressures and impedances, inspiratory and expiratory flows, and respiratory frequency. Two weeks after sternothyrohyoid myectomy, there was a statistically significant increase in translaryngeal inspiratory pressure (P = 0.035) and tracheal inspiratory pressure (P = 0.032) compared with preoperative measurements. Two weeks after sternothyrohyoid myectomy, there was a statistically significant increase in translaryngeal inspiratory resistance (P = 0.017) and tracheal inspiratory resistance (P = 0.023) compared with preoperative values. Increased translaryngeal and tracheal inspiratory pressures and resistances after sternothyrohyoid myectomy suggest that the sternothyroideus and sternohyoideus muscles act to increase or maintain upper airway patency and stability in normal horses.


Asunto(s)
Músculos Laríngeos/fisiología , Músculos/fisiología , Resistencia de las Vías Respiratorias , Animales , Femenino , Caballos , Masculino , Actividad Motora/fisiología , Presión , Valores de Referencia , Respiración , Cartílago Tiroides
7.
Equine Vet J ; 34(6): 580-6, 2002 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-12357997

RESUMEN

Frusemide reduces pulmonary vascular pressures in resting horses and attenuates exercise-induced increases in these pressures in exercising horses. The mechanism underlying these effects of frusemide is unclear. We tested the hypothesis that the haemodynamic effects of frusemide are dependent on diuresis by examining the effect of frusemide in anaesthetised horses in which diuresis was prevented by ligation of ureters. Twenty four horses were assigned randomly to one of 4 treatments: 1) frusemide (1 mg/kg bwt i.v.) and intact ureters; 2) frusemide and ligated ureters; 3) saline placebo and ligated ureters; and 4) frusemide and phenylbutazone (4.4 mg/kg bwt i.v. 12 h and 15 min before frusemide) and ligated ureters. Frusemide administration to anaesthetised horses with intact ureters increased plasma total protein concentration and reduced mean right atrial, pulmonary artery and aortic pressures. There was no significant effect of frusemide administration on haemodynamic variables or plasma total protein concentration in horses with ligated ureters. The combination of frusemide and phenylbutazone increased mean right atrial, pulmonary artery and aortic pressures in horses with ligated ureters. This study demonstrates that, in anaesthetised horses, the haemodynamic effect of frusemide is dependent upon diuresis. We interpret these results as providing further evidence that the haemodynamic effect of frusemide in horses is attributable to a reduction in plasma and blood volume.


Asunto(s)
Diuréticos/farmacología , Furosemida/farmacología , Hemodinámica/efectos de los fármacos , Caballos/fisiología , Uréter/cirugía , Adyuvantes Anestésicos , Animales , Presión Sanguínea/efectos de los fármacos , Presión Sanguínea/fisiología , Proteínas Sanguíneas/análisis , Volumen Sanguíneo/efectos de los fármacos , Volumen Sanguíneo/veterinaria , Diuresis/efectos de los fármacos , Ligadura/veterinaria , Pentobarbital , Volumen Plasmático/efectos de los fármacos , Volumen Plasmático/veterinaria
8.
Am J Vet Res ; 57(3): 250-3, 1996 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-8669749

RESUMEN

OBJECTIVE: To investigate the effect of a mask and pneumotachograph on ventilation, respiratory frequency, and tracheal and nasopharyngeal pressures in horses running on a treadmill. DESIGN: Six horses ran at 50, 75, and 100% of the speed that resulted in maximum oxygen consumption, with and without a mask and pneumotachograph. Tracheal and pharyngeal inspiratory and expiratory pressures, respiratory frequency, and arterial blood gases were measured. ANIMALS: Six Standardbred horses. PROCEDURE: Oxygen consumption was measured during an incremental exercise test to determine the speed that resulted in maximal oxygen consumption for each horse. Tracheal and pharyngeal pressures were measured, using transnasal tracheal and pharyngeal side-hole catheters connected to differential pressure transducers. Carotid arterial blood samples were collected and PAO2, PaCO2, and pH were measured with a blood gas analyzer. RESULTS: Peak tracheal and pharyngeal inspiratory pressures were significantly more negative, peak tracheal and pharyngeal expiratory pressures were significantly more positive, and respiratory frequency was significantly lower (all P < 0.05) at all speeds when horses wore a mask. The PaCO2 was higher and arterial pH and PaO2 were lower (P < 0.05) when horses wore a mask. CONCLUSIONS: The mask and pneumotachograph altered upper airway pressures, respiratory frequency, and ventilation in horses running on a treadmill.


Asunto(s)
Caballos/fisiología , Nasofaringe/fisiología , Respiración , Tráquea/fisiología , Animales , Prueba de Esfuerzo/veterinaria , Femenino , Masculino , Orquiectomía , Consumo de Oxígeno , Presión , Pruebas de Función Respiratoria/instrumentación , Pruebas de Función Respiratoria/métodos , Pruebas de Función Respiratoria/veterinaria
9.
Am J Vet Res ; 62(5): 779-82, 2001 May.
Artículo en Inglés | MEDLINE | ID: mdl-11341403

RESUMEN

OBJECTIVE: To determine the effect of a tongue-tie on upper airway mechanics in clinically normal horses exercising on a treadmill following sternothyrohyoid myectomy. ANIMALS: 6 Standardbreds. PROCEDURE: Upper airway mechanics were measured with horses exercising on a treadmill at 5, 8, and 10 m/s 4 weeks after a sternothyrohyoid myectomy was performed. Pharyngeal and tracheal inspiratory and expiratory pressures were measured by use of transnasal pharyngeal and tracheal catheters connected to differential pressure transducers. Horses were fitted with a facemask and airflow was measured by use of a pneumotachograph. Horses underwent a standardized exercise protocol on a treadmill at 5, 8, and 10 m/s with and without a tongue-tie in a randomized cross-over design. Inspiratory and expiratory airflow, tracheal pressure, and pharyngeal pressure were measured, and inspiratory and expiratory resistances were calculated. RESULTS: We were unable to detect an effect of a tongue-tie on any of the respiratory variables measured. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicate that a tongue-tie does not alter upper airway mechanics following sternothyrohyoid myectomy in clinically normal horses during exercise.


Asunto(s)
Caballos/fisiología , Condicionamiento Físico Animal/fisiología , Mecánica Respiratoria/fisiología , Lengua/fisiología , Animales , Estudios Cruzados , Femenino , Caballos/cirugía , Hueso Hioides/cirugía , Laringe/fisiología , Masculino , Músculos/cirugía , Faringe/fisiología , Distribución Aleatoria , Pruebas de Función Respiratoria/veterinaria , Estadísticas no Paramétricas , Tráquea/fisiología
10.
Am J Vet Res ; 56(5): 656-63, 1995 May.
Artículo en Inglés | MEDLINE | ID: mdl-7661463

RESUMEN

Twenty-four horses were randomly allocated to 3 groups. Horses were anesthetized, subjected to a ventral midline celiotomy, and the large colon was exteriorized and instrumented. Group-1 horses served as sham-operated controls. Group-2 horses were subjected to 6 hours of low-flow colonic arterial ischemia, and group-3 horses were subjected to 3 hours of ischemia and 3 hours of reperfusion. Baseline (BL) samples were collected, then low-flow ischemia was induced by reducing ventral colonic arterial blood flow to 20% of BL. All horses were monitored for 6 hours after BL data were collected. Blood samples were collected from the colonic vein and main pulmonary artery (systemic venous [SV]) for measurement of plasma endotoxin, 6-keto prostaglandin F1 alpha (6-kPG), thromboxane B2 (TXB2), and prostaglandin E2 (PGE2) concentrations. Tumor necrosis factor and interleukin-6 activities were measured in colonic venous (CV) serum samples. Data were analyzed, using two-way ANOVA, and post-hoc comparisons were made, using Dunnett's and Tukey's tests. Statistical significance was set at P < 0.05. Endotoxin was not detected in CV or SV plasma at any time. There was no detectable tumor necrosis factor or interleukin-6 activity in CV samples at any time. There were no differences at BL among groups for CV or SV 6-kPG, PGE2, or TXB2 concentrations, nor were there any changes across time in group-1 horses.(ABSTRACT TRUNCATED AT 250 WORDS)


Asunto(s)
Colon/irrigación sanguínea , Eicosanoides/sangre , Endotoxinas/sangre , Caballos/fisiología , Interleucina-6/sangre , Isquemia/veterinaria , Factor de Necrosis Tumoral alfa/metabolismo , Análisis de Varianza , Animales , Colon/metabolismo , Femenino , Isquemia/sangre , Isquemia/metabolismo , Masculino , Distribución Aleatoria , Reperfusión/veterinaria
11.
Am J Vet Res ; 56(5): 671-87, 1995 May.
Artículo en Inglés | MEDLINE | ID: mdl-7661465

RESUMEN

Thirty horses were randomly assigned to 1 of 5 groups. All horses were anesthetized and subjected to ventral midline celiotomy, then the large colon was exteriorized and instrumented. Colonic arterial blood flow was reduced to 20% of baseline (BL) and was maintained for 3 hours. Colonic blood flow was then restored, and the colon was reperfused for an additional 3 hours. One of 5 drug solutions was administered via the jugular vein 30 minutes prior to colonic reperfusion: group 1, 0.9% NaCl; group 2, dimethyl sulfoxide: 1 g/kg of body weight; group 3, allopurinol: 25 mg/kg; group 4, 21-aminosteroid U-74389G: 10 mg/kg; and group 5, manganese chloride (MnCl2): 10 mg/kg. Hemodynamic variables were monitored and recorded at 30-minutes intervals. Systemic arterial, systemic venous (SV), and colonic venous (CV) blood samples were collected for measurement of blood gas tensions, oximetry, lactate concentration, PCV, and plasma total protein concentration. The eicosanoids, 6-keto prostaglandin F1 alpha, prostaglandin E2, and thromboxane B2, were measured in CV blood, and endotoxin was measured in CV and SV blood. Full-thickness biopsy specimens were harvested from the left ventral colon for histologic evaluation and determination of wet weight-to-dry weight ratios (WW:DW). Data were analyzed, using two-way ANOVA for repeated measures, and statistical significance was set at P < 0.05. Heart rate, mean arterial pressure, and cardiac output increased with MnCl2 infusion; heart rate and cardiac output remained increased throughout the study, but mean arterial pressure returned to BL values within 30 minutes after completion of MnCl2 infusion. Other drug-induced changes were not significant. There were significant increases in mean pulmonary artery and mean right atrial pressures at 2 and 2.5 hours in horses of all groups, but other changes across time or differences among groups were not observed. Mean pulmonary artery pressure remained increased through 6 hours in all groups, but mean right atrial pressure had returned to BL values at 3 hours. Mean colonic arterial pressure was significantly decreased at 30 minutes of ischemia and remained decreased through 6 hours; however, by 3.25 hours it was significantly higher than the value at 3 hours of ischemia. Colonic arterial resistance decreased during ischemia and remained decreased throughout reperfusion in all groups; there were no differences among groups for colonic arterial resistance.(ABSTRACT TRUNCATED AT 400 WORDS)


Asunto(s)
Alopurinol/farmacología , Cloruros/farmacología , Colon/irrigación sanguínea , Dimetilsulfóxido/farmacología , Caballos , Compuestos de Manganeso/farmacología , Pregnatrienos/farmacología , Daño por Reperfusión/veterinaria , Análisis de Varianza , Animales , Antioxidantes/farmacología , Colon/efectos de los fármacos , Endotoxinas/análisis , Hemodinámica/fisiología , Peroxidasa/metabolismo , Daño por Reperfusión/prevención & control
12.
Am J Vet Res ; 55(10): 1434-43, 1994 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-7998702

RESUMEN

Effects of low-flow ischemia and reperfusion of the large colon on mucosal architecture were determined in horses. Twenty-four adult horses were randomly allocated to 3 groups: sham-operated (n = 6), 6 hours of ischemia (n = 9), and 3 hours of ischemia and 3 hours of reperfusion (n = 9). Low-flow ischemia was induced in horses of groups 2 and 3 by reducing colonic arterial blood flow to 20% of baseline values. Systemic hemodynamic and metabolic variables were maintained constant and in a normal physiologic range. Full-thickness biopsy specimens were obtained from the left ventral colon for histomorphologic and morphometric examination at baseline and at 30-minute intervals for 6 hours; additional biopsy specimens were collected at 185, 190, and 195 minutes (corresponding to 5-, 10-, and 15-minute periods of reperfusion in group-3 horses). There were no differences among groups at baseline or across time in group-1 horses for any of the histopathologic variables. There were significant (P < 0.05) increases in percentage of surface mucosal disruption, estimated and measured percentage depth of mucosal loss, mucosal hemorrhage, mucosal edema, and cellular debris index during 0 hour to 3 hours, compared with baseline, and from 3 hours to 6 hours, compared with 3 hours in horses of groups 2 and 3. Estimated percentage depth of mucosal loss and cellular debris index were significantly (P < 0.05) greater in group-3 horses, compared with group-2 horses during the interval from 3 to 6 hours. There were trends toward greater percentage of surface mucosal disruption and mucosal edema during the early phase of reperfusion (3 to 4 hours) and greater mucosal hemorrhage, measured percentage depth of mucosal loss, and mucosal interstitial-to-crypt ratio during the late phase (4 to 6 hours) of reperfusion in group-3 horses vs group-2 horses. Reestablishment of colonic arterial blood flow after low-flow ischemia caused greater mucosal injury than did a comparable period of continued ischemia. Thus, reperfusion injury was detected in the large colon of horses after low-flow arterial ischemia. The serial mucosal alterations that developed in the colon were comparable in horses of groups 2 and 3; however, reperfusion exacerbated colonic mucosal injury.


Asunto(s)
Colon/patología , Enfermedades de los Caballos/patología , Isquemia/veterinaria , Daño por Reperfusión/veterinaria , Análisis de Varianza , Animales , Colitis Isquémica/veterinaria , Colon/irrigación sanguínea , Femenino , Caballos , Mucosa Intestinal/patología , Isquemia/patología , Masculino , Daño por Reperfusión/patología
13.
Am J Vet Res ; 55(10): 1444-53, 1994 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-7998703

RESUMEN

Effects of low-flow ischemia and reperfusion of the large colon on systemic and colonic hemodynamic and metabolic variables were determined in horses. Twenty-four adult horses were randomly allocated to 3 groups: sham-operated (n = 6), 6 hours of ischemia (n = 9), and 3 hours of ischemia and 3 hours of reperfusion (n = 9). Low-flow ischemia was induced in groups 2 and 3 by reducing colonic arterial blood flow to 20% of baseline. Heart rate, arterial blood pressures, cardiac index, pulmonary artery pressure, right atrial pressure, and colonic blood flow were monitored. Arterial, mixed-venous, and colonic venous blood gas and oximetry analyses; PCV; and blood lactate and pyruvate and plasma total protein concentrations were measured. Data were recorded, and blood samples were collected at baseline and at 30-minute intervals for 6 hours; additionally, data were collected at 185, 190, and 195 minutes (corresponding to 5, 10, and 15 minutes of reperfusion in group-3 horses). There were no differences among groups at baseline or across time for any systemic hemodynamic or metabolic variable. Colonic blood flow did not change across time in group-1 horses. Colonic blood flow significantly (P < 0.05) decreased to 20% of baseline at induction of ischemia in horses of groups 2 and 3 and remained significantly decreased throughout the ischemic period in horses of groups 2 (6 hours) and 3 (3 hours). Colonic blood flow significantly (P < 0.05) increased above baseline by 5 minutes of reperfusion in group-3 horses. Colonic oxygen delivery and oxygen consumption, and colonic venous pH, PO2, percentage saturation of hemoglobin, and oxygen content were significantly (P < 0.05) decreased within 30 minutes after induction of ischemia in horses of groups 2 and 3; colonic venous PCO2, colonic oxygen extraction ratio, and lactate and pyruvate concentrations were significantly (P < 0.05) increased by 30 minutes of ischemia. These alterations continued throughout ischemia, but within 5 minutes of reperfusion in group-3 horses, these variables either returned to baseline (pH, PCO2, lactate, pyruvate), significantly (P < 0.05) increased above baseline (PO2, oxygen content, % saturation of hemoglobin), or significantly (P < 0.05) decreased below baseline (colonic oxygen extraction ratio). Colonic oxygen consumption remained decreased during reperfusion in group-3 horses. Colonic mucosal ischemia-reperfusion injury observed in this model of ischemia was associated with local colonic hemodynamic and metabolic alterations in the presence of systemic hemodynamic and metabolic stability.(ABSTRACT TRUNCATED AT 400 WORDS)


Asunto(s)
Colon/irrigación sanguínea , Colon/metabolismo , Hemodinámica , Enfermedades de los Caballos/fisiopatología , Isquemia/veterinaria , Daño por Reperfusión/veterinaria , Animales , Colitis Isquémica/veterinaria , Femenino , Enfermedades de los Caballos/metabolismo , Caballos , Isquemia/metabolismo , Isquemia/fisiopatología , Masculino , Daño por Reperfusión/metabolismo , Daño por Reperfusión/fisiopatología
14.
Am J Vet Res ; 55(10): 1454-63, 1994 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-7998704

RESUMEN

Histomorphologic/morphometric evaluation, leukocyte scintigraphy, and myeloperoxidase activity were used to determine whether neutrophils accumulate in the large colon of horses during low-flow ischemia and reperfusion. Twenty-four adult horses were assigned to 1 of 3 groups: group 1, sham-operated (n = 6); group 2, 6 hours of ischemia (n = 9); and group 3, 3 hours of ischemia and 3 hours of reperfusion (n = 9). Low-flow ischemia of the large colon was induced in horses of groups 2 and 3 by reducing colonic arterial blood flow to 20% of baseline. Radiolabeled (99mTc) autogenous neutrophils were injected at 175 minutes, which corresponded to 5 minutes prior to reperfusion in group-3 horses. Full-thickness biopsy specimens of the left ventral colon were collected at baseline and at 30-minute intervals for 6 hours; a portion of the biopsy specimen was placed in formalin for histologic examination, and the remainder was used to measure mucosal radioactivity and myeloperoxidase activity. There were no differences in baseline mucosal neutrophil index, mucosal neutrophil numbers, submucosal venular neutrophil numbers, mucosal radioactivity, or mucosal myeloperoxidase activity among groups, or over time in group-1 horses. Neutrophils accumulated in the colonic mucosa during ischemia and further increased at reperfusion, as indicated by neutrophil index (morphology) and mucosal neutrophil numbers (morphometry); mucosal neutrophil index was significantly (P < 0.05) greater in group-3 horses during reperfusion than at the corresponding periods of ischemia in group-2 horses. Neutrophil numbers were significantly (P < 0.05) increased in submucosal venules at 10 minutes of reperfusion in group-3 horses and were significantly (P < 0.05) greater in group-3 than in group-2 horses during the interval from 3 to 6 hours. Mucosal radioactivity significantly (P < 0.05) increased at reperfusion in group-3 horses; there was a trend (P = 0.076) toward greater mucosal radioactivity in group-3, compared with group-2 horses, throughout the 3- to 6-hour interval. There were no differences in mucosal myeloperoxidase activity among or within any of the 3 groups over time. Neutrophils accumulated in the large colon of horses during low-flow ischemia and reperfusion. Neutrophil infiltration was detected by histologic examination and leukocyte scintigraphy, but not by measurement of myeloperoxidase activity. The accumulation of neutrophils during ischemia and the further neutrophil infiltration during reperfusion indicate that neutrophils may contribute to reperfusion injury of the large colon.


Asunto(s)
Colon/citología , Enfermedades de los Caballos/patología , Isquemia/veterinaria , Neutrófilos/fisiología , Daño por Reperfusión/veterinaria , Animales , Colitis Isquémica/veterinaria , Colon/diagnóstico por imagen , Femenino , Enfermedades de los Caballos/diagnóstico por imagen , Enfermedades de los Caballos/enzimología , Caballos , Mucosa Intestinal/enzimología , Isquemia/diagnóstico por imagen , Isquemia/enzimología , Isquemia/patología , Masculino , Peroxidasa/biosíntesis , Cintigrafía , Daño por Reperfusión/diagnóstico por imagen , Daño por Reperfusión/enzimología , Daño por Reperfusión/patología
15.
Am J Vet Res ; 58(9): 1018-21, 1997 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-9285008

RESUMEN

OBJECTIVE: To investigate the effect of combined staphylectomy and laryngotomy on upper airway mechanics in clinically normal horses running on a treadmill. ANIMALS: 6 Standardbreds. PROCEDURE: Upper airway mechanics were measured with horses trotting or pacing on a treadmill at 5, 8, and 10 m/s before and 6 weeks after combined staphylectomy and laryngotomy. Pharyngeal and tracheal inspiratory and expiratory pressure were measured by use of transnasal tracheal and pharyngeal side hole catheters connected to differential pressure transducers. A pneumotachograph mounted on the rostral end of an airtight face mask was used to measure airflow. RESULTS: Upper airway and translaryngeal inspiratory impedances were higher, respiratory rate was decreased, and inspiratory time was longer (P < 0.05) at all speeds after staphylectomy and laryngotomy. CONCLUSION: Combined staphylectomy and laryngotomy significantly affects upper airway mechanics in clinically normal horses. CLINICAL RELEVANCE: Because combined staphylectomy and laryngotomy exerts a potentially adverse effect on upper airway mechanics in clinically normal horses, the procedure should only be performed when it is clearly indicated.


Asunto(s)
Caballos/fisiología , Laringe/cirugía , Esfuerzo Físico/fisiología , Respiración , Úvula/cirugía , Animales , Prueba de Esfuerzo/veterinaria , Femenino , Masculino , Orquiectomía
16.
J Am Vet Med Assoc ; 196(3): 453-4, 1990 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-2298677

RESUMEN

Congenital frontal sinus cysts were found bilaterally in the frontal sinuses of a one-year-old miniature horse. Diagnosis was based on radiography of the head and cytologic examination of tissue aspirated from the frontal sinuses. The cysts were surgically removed, using a hinged bone flap technique bilaterally over the frontal sinuses.


Asunto(s)
Quistes/veterinaria , Seno Frontal , Enfermedades de los Caballos/congénito , Enfermedades de los Senos Paranasales/veterinaria , Animales , Quistes/congénito , Quistes/cirugía , Femenino , Enfermedades de los Caballos/cirugía , Caballos , Enfermedades de los Senos Paranasales/congénito , Enfermedades de los Senos Paranasales/cirugía
17.
J Am Vet Med Assoc ; 200(12): 1978-80, 1992 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-1639709

RESUMEN

Irreducible ileocecal intussusceptions pose a difficult surgical problem. Strangulating ileocecal intussusceptions involving the ileum and jejunum were identified in 2 horses undergoing exploratory laparotomy because of colic. Surgical correction in both horses was achieved by amputation of the ileocecal intussusception from within the cecal lumen, via typhlotomy. The inverted ileal stump was blindly stapled near the ileocecal orifice after pulling the intussusceptum into the cecum. A jejunocecostomy was performed to reestablish intestinal continuity.


Asunto(s)
Enfermedades de los Caballos/cirugía , Enfermedades del Íleon/veterinaria , Válvula Ileocecal , Intususcepción/veterinaria , Animales , Ciego/cirugía , Femenino , Caballos , Enfermedades del Íleon/cirugía , Intususcepción/cirugía , Yeyuno/cirugía , Engrapadoras Quirúrgicas/veterinaria
18.
J Am Vet Med Assoc ; 204(10): 1655-9, 1994 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-8050949

RESUMEN

Medical records for 64 Thoroughbred and 45 Standardbred horses with osteochondrosis dissecans (OCD) of the tarsocrural joint that were treated by means of arthroscopic removal of the fragments before 2 years of age and before beginning racing were reviewed. Lesion site was recorded for all horses. The other foals from the dams of these surgically treated horses (siblings) were identified from mare progeny records. Racing data, including number of starts and money won during the 2- and 3-year-old racing years were obtained from the Jockey Club and the United States Trotting Association for affected horses and their siblings. Statistical analysis was performed to test the hypothesis that there was no difference between the racing performance of horses with OCD of the tarsocrural joint that were surgically treated by means of arthroscopic removal of the fragments prior to racing and that of their siblings. One hundred and seventy-four lesions were recorded in 109 horses. The distribution of lesions was similar to that previously reported. For the Standardbreds, 22% of those that had surgery raced as 2 year olds and 43% raced as 3 year olds, compared with 42 and 50% of the siblings that raced as 2 year olds and 3 year olds, respectively. For the Thoroughbreds, 43% of those that had surgery raced as 2 year olds and 78% raced as 3 year olds, compared with 48% and 73% of the siblings that raced as 2 year olds and 3 year olds, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)


Asunto(s)
Enfermedades de los Caballos/cirugía , Osteocondritis Disecante/veterinaria , Tarso Animal/cirugía , Animales , Artroscopía/veterinaria , Cruzamiento , Estudios de Casos y Controles , Femenino , Estudios de Seguimiento , Miembro Posterior , Caballos , Masculino , Osteocondritis Disecante/cirugía , Estudios Retrospectivos , Deportes , Resultado del Tratamiento
19.
J Am Vet Med Assoc ; 214(11): 1648-52, 1999 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-10363097

RESUMEN

OBJECTIVE: To compare fracture locations, repair methods, complications, and outcomes of horses with fractures of the rostral portions of the mandible and maxilla. DESIGN: Retrospective study. ANIMALS: 89 horses with fractures of the rostral portions of the mandible and maxilla. PROCEDURE: Medical records and radiographs were reviewed. Fractures were categorized by fracture location and stability. Postoperative complications and long-term outcome were determined by clinical examination and telephone interviews with horse owners. RESULTS: 4 fracture types were recognized. Fractures involving just the alveolar plate (33%) and those involving the alveolar plate and the body of the bone (32%) were most common and were often repaired by interdental wiring. Unilateral fractures of the mandible (11%) were managed without surgery if stable. Unstable fractures were repaired with wires, a U-shaped bar (U-bar), or a bone plate. Bilateral fractures (24%) were often repaired with orthopedic wires in foals or with a U-bar, acrylic splint, wires, or bone plate in adult horses. In 2 horses, bilateral fractures were managed conservatively. Short-term complications developed in 24 of 89 (27%) horses. Soft tissue infections and wire loosening or failure were the most common short-term and long-term complications. Wire replacement was not required in any horses after release from hospital. Persistent draining tracts were most often associated with bone sequestration. Long-term functional and cosmetic outcomes were favorable for all fracture types and repair methods. CLINICAL IMPLICATIONS: Although complications in horses with fractures of the mandible and maxilla are common, long-term prognoses for functional and cosmetic outcome are favorable.


Asunto(s)
Caballos/lesiones , Fracturas Mandibulares/veterinaria , Fracturas Maxilares/veterinaria , Animales , Placas Óseas/veterinaria , Tornillos Óseos/veterinaria , Hilos Ortopédicos/veterinaria , Femenino , Estudios de Seguimiento , Fijación Interna de Fracturas/veterinaria , Incisivo/lesiones , Masculino , Fracturas Mandibulares/complicaciones , Fracturas Mandibulares/terapia , Fracturas Maxilares/complicaciones , Fracturas Maxilares/terapia , Complicaciones Posoperatorias/veterinaria , Prótesis e Implantes/veterinaria , Estudios Retrospectivos , Fracturas de los Dientes/complicaciones , Fracturas de los Dientes/terapia , Fracturas de los Dientes/veterinaria , Resultado del Tratamiento
20.
J Am Vet Med Assoc ; 201(3): 483-6, 1992 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-1506260

RESUMEN

Pharyngeal or esophageal trauma was diagnosed in 9 horses after nasogastric intubation. Evidence of trauma (edema or ulceration) was detected in the pharynx of 3 horses and in the esophagus of 6 horses. Complications associated with nasogastric intubation were first observed in 5 horses while they were intubated and in 4 horses after extubation. Clinical signs of pharyngeal or esophageal trauma were similar, and included salivation, bruxism, coughing, and nasal discharge. Treatment, including extubation, enteral feeding through a small nasogastric tube, or esophagostomy distal to the affected site, was attempted in 6 horses. Three of 6 treated horses survived, but 4 of 5 horses with perforated esophagus were euthanatized.


Asunto(s)
Esófago/lesiones , Caballos/lesiones , Intubación Gastrointestinal/efectos adversos , Faringe/lesiones , Animales , Nutrición Enteral/veterinaria , Esofagoscopía/veterinaria , Esofagostomía/veterinaria , Estudios Retrospectivos , Resultado del Tratamiento , Heridas y Lesiones/etiología , Heridas y Lesiones/terapia , Heridas y Lesiones/veterinaria
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