A progressively wetter climate in southern East Africa over the past 1.3 million years.

African climate is generally considered to have evolved towards progressively drier conditions over the past few million years, with increased variability as glacial-interglacial change intensified worldwide. Palaeoclimate records derived mainly from northern Africa exhibit a 100,000-year (eccentricity) cycle overprinted on a pronounced 20,000-year (precession) beat, driven by orbital forcing of summer insolation, global ice volume and long-lived atmospheric greenhouse gases. Here we present a 1.3-million-year-long climate history from the Lake Malawi basin (10°-14° S in eastern Africa), which displays strong 100,000-year (eccentricity) cycles of temperature and rainfall following the Mid-Pleistocene Transition around 900,000 years ago. Interglacial periods were relatively warm and moist, while ice ages were cool and dry. The Malawi record shows limited evidence for precessional variability, which we attribute to the opposing effects of austral summer insolation and the temporal/spatial pattern of sea surface temperature in the Indian Ocean. The temperature history of the Malawi basin, at least for the past 500,000 years, strongly resembles past changes in atmospheric carbon dioxide and terrigenous dust flux in the tropical Pacific Ocean, but not in global ice volume. Climate in this sector of eastern Africa (unlike northern Africa) evolved from a predominantly arid environment with high-frequency variability to generally wetter conditions with more prolonged wet and dry intervals.

Effects of buprenorphine on acute pain and inflammation in the adjuvant-induced monoarthritis rat model.

Background and aim: Animal modelling of arthritis is often associated with pain and suffering. Severity may be reduced with the use of analgesia which is, however, often withheld due to concerns of introducing a confounding variable. It is therefore important to design and validate pain relief protocols that reduce pain without compromising the scientific objectives. The present study evaluated the effect of buprenorphine analgesia in the immediate post-induction period of an adjuvant-induced monoarthritic rat model. The aim of this study was to extend previous work on refinement of the model by alleviating unnecessary pain. Methods: Male and female Sprague Dawley rats were injected with 20 µl of complete Freund's adjuvant (CFA) into the left ankle. Rats were treated with buprenorphine, either injected subcutaneously or ingested voluntarily, and were compared to rats given subcutaneous injections with vehicle (saline or pure nut paste) or carprofen the first three days post CFA-injection. Measurements of welfare, clinical model-specific parameters and pain-related behaviour were assessed. Results: Buprenorphine, administered either subcutaneously (0.10 or 0.15 mg/kg, twice daily) or by voluntary ingestion in nut paste (1.0 or 3.0 mg/kg, twice daily), improved mobility, stance, rearing and lameness scores significantly 7 h post CFA-injection. Mechanical hyperalgesia peaked at 7 h and was significantly lower in buprenorphine-treated animals, compared to vehicle-treated animals. Joint circumference was highest 24-72 h after CFA injection. Animals treated with buprenorphine did not decrease in joint circumference, opposite carprofen treated animals. Conclusion: Buprenorphine, administered either subcutaneously or by voluntary ingestion, provides adequate analgesia for both sexes within the first 24 h post CFA-injection. Buprenorphine treatment improved clinical scores and appeared not to suppress the inflammatory response. The present study supports previous findings that voluntarily ingested buprenorphine is an effective alternative to repeated injections.

Persistent influence of precession on northern ice sheet variability since the early Pleistocene.

Prior to ~1 million years ago (Ma), variations in global ice volume were dominated by changes in obliquity; however, the role of precession remains unresolved. Using a record of North Atlantic ice rafting spanning the past 1.7 million years, we find that the onset of ice rafting within a given glacial cycle (reflecting ice sheet expansion) consistently occurred during times of decreasing obliquity whereas mass ice wasting (ablation) events were consistently tied to minima in precession. Furthermore, our results suggest that the ubiquitous association between precession-driven mass wasting events and glacial termination is a distinct feature of the mid to late Pleistocene. Before then (increasing), obliquity alone was sufficient to end a glacial cycle, before losing its dominant grip on deglaciation with the southward extension of Northern Hemisphere ice sheets since ~1 Ma.

Autocorrelation based denoising of manatee vocalizations using the undecimated discrete wavelet transform.

Recent interest in the West Indian manatee (Trichechus manatus latirostris) vocalizations has been primarily induced by an effort to reduce manatee mortality rates due to watercraft collisions. A warning system based on passive acoustic detection of manatee vocalizations is desired. The success and feasibility of such a system depends on effective denoising of the vocalizations in the presence of high levels of background noise. In the last decade, simple and effective wavelet domain nonlinear denoising methods have emerged as an alternative to linear estimation methods. However, the denoising performances of these methods degrades considerably with decreasing signal-to-noise ratio (SNR) and therefore are not suited for denoising manatee vocalizations in which the typical SNR is below 0 dB. Manatee vocalizations possess a strong harmonic content and a slow decaying autocorrelation function. In this paper, an efficient denoising scheme that exploits both the autocorrelation function of manatee vocalizations and effectiveness of the nonlinear wavelet transform based denoising algorithms is introduced. The suggested wavelet-based denoising algorithm is shown to outperform linear filtering methods, extending the detection range of vocalizations.

Disability simulations and information: techniques for modifying the attitudes of elementary school music students.

The purpose of this study was to determine the effect of different presentation formats (information and simulation) on the attitudes of elementary music students toward children with special needs. A questionnaire was initially administered to 11 elementary music classes (N = 198). Examination showed a 0.86 difference between highest and lowest rated disabilities on 6-point scale on the first administration. Females showed slightly more favorable attitudes than males for each of the 6 disability categories. Rank ordering indicated an identical ranking between genders with Learning Disabilities most accepted and Visual Impairments least accepted. Prior to the second administration, classes received different preparations: (a) information-based, (b) simulation-based, (c) contact-control. Results of the second administration showed no significant difference among treatment groups on gain scores with only a slight increase noted for the simulation-based treatment.