RESUMEN
A case of temporary congenital hypoaldosteronism with normal production of other hormones of the adrenal is described. During early infancy the patient showed low blood aldosterone levels, increased ACHT and Hyponatraemia. Replacement therapy needed sodium chloride and mineralcorticoid drug administration (Florinef) until the baby was 9 month old. Later, spontaneous recovery occurred, confirmed by laboratory tests.
Asunto(s)
Aldosterona/deficiencia , Femenino , Humanos , Recién Nacido , Desequilibrio Hidroelectrolítico/congénito , Desequilibrio Hidroelectrolítico/terapiaRESUMEN
A male infant with profound anemia and liver and spleen enlargement was affected by visceral Leishmaniasis. Diagnostic tests and therapeutical approach to this parasitic infection, very rare in our Region, are discussed.
Asunto(s)
Leishmaniasis Visceral/diagnóstico , Anemia Hipocrómica/etiología , Biopsia , Médula Ósea/patología , Hepatomegalia/etiología , Humanos , Leishmaniasis Visceral/complicaciones , Masculino , Esplenomegalia/etiologíaRESUMEN
The aim of this study was to evaluate, in vitro, the antiviral activity of a chemical contraceptive (Nonoxynol-9). The results have demonstrated that such a compound is able to inhibit the infectivity of enveloped viruses. It seems that the activity of this contraceptive is due to the lesion of the envelope.
PIP: The action in vitro of chemical intravaginal contraceptives against bacteria and fungi has already been demonstrated and its antiviral activity is now undergoing testing. Nonoxynol-9 was tested on herpes simplex type II, respiratory sincipital virus and polio virus type II; the viruses were grown in human fetal fibroblasts, continued-line human cells, and continued-line monkey kidney cells. A cytotoxic effect was demonstrated up to a 1-10 dilution of the basic solution within 1 minute, without variances between different cellular lines. The results were tested against untreated control colonies. This study shows the efficacy of 1 chemical contraceptive against unrelated viruses; the target seems to be the pericapsidic membrane. This suggests a possible role for these drugs in the prevention of sexually transmitted venereal diseases such as HTLV-III and herpes.