Detalles de la búsqueda
1.
New 2-oxoindole derivatives as multiple PDGFRα/ß and VEGFR-2 tyrosine kinase inhibitors.
Bioorg Chem
; 145: 107234, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38412650
2.
Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition.
Bioorg Chem
; 134: 106444, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36893547
3.
New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization.
Mol Divers
; 2023 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36790582
4.
Discovery of new cyanopyridine/chalcone hybrids as dual inhibitors of EGFR/BRAFV600E with promising antiproliferative properties.
Arch Pharm (Weinheim)
; 356(4): e2200464, 2023 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-36526595
5.
Discovery of oxindole-based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation.
Arch Pharm (Weinheim)
; 356(2): e2200407, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36403191
6.
Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis-Pyrazoline Derivatives as Dual EGFR/BRAFV600E Inhibitors.
Int J Mol Sci
; 24(10)2023 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37240450
7.
Combination of an Oxindole Derivative with (-)-ß-Elemene Alters Cell Death Pathways in FLT3/ITD+ Acute Myeloid Leukemia Cells.
Molecules
; 28(13)2023 Jul 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37446914
8.
Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAFV600E Inhibitory Pathways.
Molecules
; 28(18)2023 Sep 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37764362
9.
Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities.
Bioorg Chem
; 129: 106171, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36166898
10.
Pyrrolizine/Indolizine-NSAID Hybrids: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies.
Molecules
; 26(21)2021 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-34770990
11.
HSP70 induction by bleomycin metal core analogs.
Bioorg Med Chem Lett
; 30(7): 127002, 2020 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32044184
12.
New 1,3,4-oxadiazole/oxime hybrids: Design, synthesis, anti-inflammatory, COX inhibitory activities and ulcerogenic liability.
Bioorg Chem
; 74: 15-29, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28738249
13.
Novel 1,3,4-oxadiazole/oxime hybrids: Synthesis, docking studies and investigation of anti-inflammatory, ulcerogenic liability and analgesic activities.
Bioorg Chem
; 69: 48-63, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27669120
14.
Novel metal chelating molecules with anticancer activity. Striking effect of the imidazole substitution of the histidine-pyridine-histidine system.
Bioorg Med Chem
; 23(17): 5476-82, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26260338
15.
New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities.
Bioorg Med Chem
; 21(13): 3839-49, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23665142
16.
Indole-based FLT3 inhibitors and related scaffolds as potential therapeutic agents for acute myeloid leukemia.
BMC Chem
; 17(1): 73, 2023 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37438819
17.
Vanillin-Based Indolin-2-one Derivative Bearing a Pyridyl Moiety as a Promising Anti-Breast Cancer Agent via Anti-Estrogenic Activity.
ACS Omega
; 8(7): 6968-6981, 2023 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36844536
18.
Design and Synthesis of New Hydantoin Acetanilide Derivatives as Anti-NSCLC Targeting EGFRL858R/T790M Mutations.
Pharmaceuticals (Basel)
; 15(7)2022 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35890154
19.
Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors.
Pharmaceuticals (Basel)
; 15(9)2022 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36145373
20.
Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation.
Eur J Med Chem
; 146: 79-92, 2018 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29396364