Optimal control in a magnetization-prepared rapid acquisition gradient-echo sequence.

This article proposes a numerical framework to determine the optimal magnetization preparation in a three-dimensional magnetization-prepared rapid gradient-echo (MP-RAGE) sequence to obtain the best achievable contrast between target tissues based on differences in their relaxation times. The benefit lies in the adaptation of the algorithm of optimal control, GRAdient Ascent Pulse Engineering (GRAPE), to the optimization of magnetization preparation in a cyclic sequence without full recovery between each cycle. This numerical approach optimizes magnetization preparation of an arbitrary number of radio frequency pulses to enhance contrast, taking into account the establishment of a steady state in the longitudinal component of the magnetization. The optimal control preparation offers an optimized mixed T 1 / T 2 contrast in this traditional T 1 -weighted sequence. To show the versatility of the proposed method, numerical and in vitro results are described. Examples of contrasts acquired on brain regions of a healthy volunteer are presented for potential applications at 3 T.

In vitro rat colonic wall imaging with MR endoluminal coil: feasibility study and histologic correlations.

RATIONALE AND OBJECTIVES: Despite improvements, spatial resolution and image quality with routine surface coils are too limited when detailed information about the gastrointestinal layers is requested. The objective of our feasibility study was to evaluate the potential of a dedicated endoluminal coil to depict different layers of the colonic wall in an in vitro small animal model. MATERIALS AND METHODS: A single-loop coil (40 mm length, 5 mm width) was built using IC (printed circuit) technology. The coil was tuned to a frequency of 63.7 MHz and matched at 50 Omega for this frequency. The coil was housed in a biocompatible tube with an outer diameter of 18 F (6 mm). Ten segments of rat colon, surgically excised 5 hours earlier, were completely immersed in an isotonic solution. The coil was introduced through the lumen of colonic specimens. MRI experiments were performed on a 1.5 T MR Symphony system (Siemens, Erlangen, Germany) using imaging protocol combining high-resolution 2D Flash, fast imaging employing steady-state acquisition (TrueFISP), turbo spin echo (TSE), and 3D FastLow-Angle Shot (FLASH) sequences. After a 24-hour period of fixation in 10% formalin, colonic specimens were excised along the longitudinal axis for histologic analysis. RESULTS: The endoluminal coil provided high SNR allowing for the visualization of different layers of rat colonic walls. All the performed sequences made it possible to identify at least two different layers. On T1-weighted gradient-echo sequences, the mucosa was of high signal intensity, whereas the muscle layers had an intermediate to low signal intensity. The signal intensity of different wall layers was similar in different sequences. Histologic analysis identified three main layers. CONCLUSION: These results are well correlated with histologic findings and suggest that endoluminal MR imaging may have potential for accurate staging of colonic tumor or inflammatory process.