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1.
Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo.
Proc Natl Acad Sci U S A
; 115(46): E10907-E10914, 2018 11 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30381459
2.
N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.
J Med Chem
; 50(5): 1078-82, 2007 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-17298049
3.
Novel antibacterial class: a series of tetracyclic derivatives.
J Med Chem
; 49(16): 4842-56, 2006 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-16884296
4.
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
J Med Chem
; 49(13): 3770-3, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789734
5.
An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF.
J Biomol Screen
; 11(7): 743-54, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16973923
6.
Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.
J Biomol Screen
; 21(6): 608-19, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-26969322
7.
Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.
Protein Sci
; 14(12): 3039-47, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16322581
8.
Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.
J Med Chem
; 47(7): 1709-18, 2004 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-15027862
9.
A strategy for high-throughput assay development using leads derived from nuclear magnetic resonance-based screening.
J Biomol Screen
; 7(5): 429-32, 2002 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-14599358
10.
A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen.
J Biomol Screen
; 9(1): 3-11, 2004 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-15006143
11.
Antibacterial drug discovery in the post-genomics era.
Curr Drug Targets Infect Disord
; 2(2): 109-19, 2002 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12462143
12.
The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.
Bioorg Med Chem Lett
; 17(6): 1803-7, 2007 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17234407
13.
Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.
Bioorg Med Chem Lett
; 17(7): 1961-5, 2007 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17267221
14.
From bacterial genomes to novel antibacterial agents: discovery, characterization, and antibacterial activity of compounds that bind to HI0065 (YjeE) from Haemophilus influenzae.
Chem Biol Drug Des
; 69(6): 395-404, 2007 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-17581233
15.
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
Bioorg Med Chem Lett
; 16(23): 6078-81, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16973360
16.
Structure-based optimization of MurF inhibitors.
Chem Biol Drug Des
; 67(1): 58-65, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16492149
17.
Mechanism of action of a novel series of naphthyridine-type ribosome inhibitors: enhancement of tRNA footprinting at the decoding site of 16S rRNA.
Antimicrob Agents Chemother
; 49(5): 1890-7, 2005 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15855511
18.
Novel approach to mapping of resistance mutations in whole genomes by using restriction enzyme modulation of transformation efficiency.
Antimicrob Agents Chemother
; 49(7): 2767-77, 2005 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15980348
19.
Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives.
Bioorg Med Chem Lett
; 15(11): 2716-9, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15911248
20.
SOS-NMR: a saturation transfer NMR-based method for determining the structures of protein-ligand complexes.
J Am Chem Soc
; 126(8): 2390-8, 2004 Mar 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-14982445