The 13CO-rich atmosphere of a young accreting super-Jupiter.

Isotope abundance ratios have an important role in astronomy and planetary sciences, providing insights into the origin and evolution of the Solar System, interstellar chemistry and stellar nucleosynthesis1,2. In contrast to deuterium/hydrogen ratios, carbon isotope ratios are found to be roughly constant (around 89) in the Solar System1,3, but do vary on galactic scales with a 12C/13C isotopologue ratio of around 68 in the current local interstellar medium4-6. In molecular clouds and protoplanetary disks, 12CO/13CO ratios can be altered by ice and gas partitioning7, low-temperature isotopic ion-exchange reactions8 and isotope-selective photodissociation9. Here we report observations of 13CO in the atmosphere of the young, accreting super-Jupiter TYC 8998-760-1 b, at a statistical significance of more than six sigma. Marginalizing over the planet's atmospheric temperature structure, chemical composition and spectral calibration uncertainties suggests a 12CO/13CO ratio of [Formula: see text](90% confidence), a substantial enrichment in 13C with respect to the terrestrial standard and the local interstellar value. As the current location of TYC 8998-760-1 b at greater than or equal to 160 astronomical units is far beyond the CO snowline, we postulate that it accreted a substantial fraction of its carbon from ices enriched in 13C through fractionation.

Using a coherent hydrophone array for observing sperm whale range, classification, and shallow-water dive profiles.

Sperm whales in the New England continental shelf and slope were passively localized, in both range and bearing, and classified using a single low-frequency (<2500 Hz), densely sampled, towed horizontal coherent hydrophone array system. Whale bearings were estimated using time-domain beamforming that provided high coherent array gain in sperm whale click signal-to-noise ratio. Whale ranges from the receiver array center were estimated using the moving array triangulation technique from a sequence of whale bearing measurements. Multiple concurrently vocalizing sperm whales, in the far-field of the horizontal receiver array, were distinguished and classified based on their horizontal spatial locations and the inter-pulse intervals of their vocalized click signals. The dive profile was estimated for a sperm whale in the shallow waters of the Gulf of Maine with 160 m water-column depth located close to the array's near-field where depth estimation was feasible by employing time difference of arrival of the direct and multiply reflected click signals received on the horizontal array. By accounting for transmission loss modeled using an ocean waveguide-acoustic propagation model, the sperm whale detection range was found to exceed 60 km in low to moderate sea state conditions after coherent array processing.

Development of an automated manufacturing process for large-scale production of autologous T cell therapies.

Engineered T cell therapies have shown significant clinical success. However, current manufacturing capabilities present a challenge in bringing these therapies to patients. Furthermore, the cost of development and manufacturing is still extremely high due to complexity of the manufacturing process. Increased automation can improve quality and reproducibility while reducing costs through minimizing hands-on operator time, allowing parallel manufacture of multiple products, and reducing the complexity of technology transfer. In this article, we describe the results of a strategic alliance between GSK and Miltenyi Biotec to develop a closed, automated manufacturing process using the CliniMACS Prodigy for autologous T cell therapy products that can deliver a high number of cells suitable for treating solid tumor indications and compatible with cryopreserved apheresis and drug product. We demonstrate the ability of the T cell Transduction - Large Scale process to deliver a significantly higher cell number than the existing process, achieving 1.5 × 1010 cells after 12 days of expansion, without affecting other product attributes. We demonstrate successful technology transfer of this robust process into three manufacturing facilities.