[Medical therapies for locally advanced/metastatic kidney cancer]. / Traitements médicaux des cancers du rein localement avancés et/ou métastatiques.

AIMS: To analyze the medical literature concerning the results of the international randomized muticentric trials concerning therapeutic innovations, mainly targeted therapies in locally advanced and or metastatic renal cell cancer and to evaluate the benefit of these TT. METHODS: We performed a review of publications that concerned this topic published from 2000 to 2014. RESULTS: They concerned the large randomized trials have showed a benefit of the targeted therapies in the treatment of clear cell carcinomas in terms of progression-free survival. CONCLUSION: Advances in molecular biology have allowed the development of these targeted therapies that have all proved their role in the treatment of metastatic renal cell carcinoma.