Diet and odor hedonic ratings: comparative study between vegetarians, flexitarians, and omnivores.

OBJECTIVES: Odor hedonic perception is well known to exhibit great variability and to depend on several parameters, i.e. stimulus, context, and subject characteristics. As hedonic perception (pleasant/unpleasant character) of food odors is considered one of the most prominent dimensions in eating behavior, the question of hedonic variability in this context arises. Thus, the aim of the present study was to compare odor hedonic ratings in three populations with regard to diet (i.e. omnivore, vegetarian, and flexitarian diets). METHODS: Four categories of odors were compared: meat, vegetable, other food, and non-food odors. RESULTS: The results showed that vegetarian and flexitarian individuals rated meat odors as more unpleasant than omnivores, while no significant difference was found for other categories of odors. DISCUSSION: The question of whether the diet influences the hedonic perception or/and inversely is discussed, regarding several aspects of food consumption such as eating disorders, food education, … and could further serve to manage eating behaviors. PRACTICAL APPLICATIONS: This study evidenced that vegetarians and flexitarians specifically rated meat odors as being more unpleasant than those of omnivores. Because of the growing number of vegetarians and flexitarians in the general population, it could be suggested to take into account the odor hedonic perception (especially regarding food odors) in studies related to diets. Besides, the present results could further serve research in several aspects of food consumption such as eating disorders (anorexia, bulimia … etc.) or food education as well as the management of eating behaviors, especially in an elderly population.

Variability in odor hedonic perception: A challenge for neurosensory and behavioral research.

Odor hedonic perception (pleasant/unpleasant character) is considered to be the first and one of the most important dimensions in olfaction and is known to be highly variable and dependent on several factors related to the stimulus, individual characteristics, and context. Although numerous experimental studies have been published on this topic, there is no comprehensive general review on the variability in odor hedonic perception. Therefore, the aim of this article was to describe and detail all the factors involved in the variability in odor hedonic perception. Stimulus properties-related variability includes the concentration/intensity and the physicochemical properties. Individual-related variability includes sex, age, and physiological state characteristics, while context-related variability involves factors associated with the stimulation context, such as stimulation pathway, exposure frequency, verbal influences, cross-modal associations, hedonic contrast, and cultural background. Subsequently, a section is devoted to the brain processing of odor hedonicity, although its role in odor hedonic variability is largely unknown. Finally, the article discusses the relationship between the hedonic qualities of odors and the resulting behavioral responses in both animals and humans. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

A study on the relationship between odor hedonic ratings and individual odor detection threshold.

Odor hedonic perception (pleasant/unpleasant character) is considered as the first and one of the most prominent dimensions in olfaction and is known to depend on several parameters. Among them, the relation between the odorant concentration and the hedonic estimation has been widely studied. However, few studies have considered odor hedonic ratings (OHR) in relation to individual detection thresholds (IDT). Thus, the aim of this study was to determine olfactory detection thresholds and to describe hedonic rating variations from individual thresholds to higher concentrations. IDT were performed for two pleasant (apple and jasmine) and two unpleasant (durian and trimethylamine) odorant stimuli. The experimenter presented one by one in a randomized order, the different odorant concentrations above IDT. Participants rated odor hedonic valence of these stimuli on a visual analog scale. Results showed, except for trimethylamine, the same relationship between hedonic ratings and stimulus concentration, i.e., an increase of pleasantness (apple and jasmine)/unpleasantness (durian) ratings at low and middle concentrations followed by a plateau at high concentrations. Correlations between OHR and concentrations as well as between OHR and threshold steps were always significant. Moreover, comparisons between both conditions showed that the correlation coefficient was significantly higher for trimethylamine (and a trend for apple) when IDTs were considered, while no difference was found for jasmine and durian. Overall, results suggested that the relationship between OHR and IDT is odor specific. These findings contribute to explain the large variability of the hedonic tone (i.e., weakly vs. very pleasant, weakly vs. very unpleasant) at specific concentration in the general population and could serve future research in this field (e.g., olfactory preferences in nutrition studies, anhedonia in psychiatric disorders…).

Toxicity of carbon dioxide: a review.

The toxicity of carbon dioxide has been established for close to a century. A number of animal experiments have explored both acute and long-term toxicity with respect to the lungs, the cardiovascular system, and the bladder, showing inflammatory and possible carcinogenic effects. Carbon dioxide also induces multiple fetal malformations and probably reduces fertility in animals. The aim of the review is to recapitulate the physiological and metabolic mechanisms resulting from CO(2) inhalation. As smokers are exposed to a high level of carbon dioxide (13%) that is about 350 times the level in normal air, we propose the hypothesis that carbon dioxide plays a major role in the long term toxicity of tobacco smoke.

Sex Differences in Odor Hedonic Perception: An Overview.

Odor hedonic evaluation (pleasant/unpleasant) is considered as the first and one of the most prominent dimension in odor perception. While sex differences in human olfaction have been extensively explored, gender effect in hedonic perception appears to be less considered. However, a number of studies have included comparisons between men and women, using different types of measurements (psychophysical, psychophysiological,…). This overview presents experimental works with non-specific and body odors separately presented as well as experimental studies comparing healthy participants vs patients with psychiatric disorders. Contrary to sensitivity, identification or discrimination, the overall literature tends to prove that no so clear differences occur in odor hedonic judgment between men and women. On the whole, gender effect appears more marked for body than non-specific odors and is almost never reported in psychiatric diseases. These findings are discussed in relation to the processes classically implied in pleasantness rating and emotional processes.

Effects of CO2 inhalation exposure on mice vomeronasal epithelium.

Nasal epitheliums are the first sites of the respiratory tract in contact with the external environment and may therefore be susceptible to damage from exposure to many toxic volatile substances (i.e., volatile organic components, vapors, and gases). In the field of inhalation toxicology, a number of studies have considered the main olfactory epithelium, but few have dealt with the epithelium of the vomeronasal organ (VNO). However, in several species such as in rodents, the VNO (an organ of pheromone detection) plays an important role in social interactions, and alterations of this organ are known to induce adaptative behavioral disturbances. Among volatile toxicants, health effects of inhaled gases have been thoroughly investigated, especially during CO(2) inhalation because of its increasing atmospheric concentration. Therefore, this work was designed to examine the effects of 3% CO(2) inhalation on VNO in two different exposure conditions (5 h/day and 12 h/day) in mice. Behavioral sensitivity tests to urine of congener and histological measurements of VNO were conducted before, during (weeks 1-4), and after (weeks 5-8) CO(2) inhalation exposures. Results showed no significant modifications of behavioral responses to urine, but there were significant changes of both cell number and thickness of the VNO epithelium. Moreover, the findings indicated a selectively dose-dependent effect of CO(2), and further research could use other gases in the same manner for comparison.

Patterns of cerebral activation during olfactory and trigeminal stimulations.

It is well known that most odorants stimulate both the olfactory system and the trigeminal system. However, the overlap between the brain processes involved in each of these sensorial perceptions is still poorly documented. This study aims to compare fMRI brain activations while smelling two odorants of a similar perceived intensity and pleasantness: phenyl ethyl alcohol (a pure olfactory stimulus) and iso-amyl-acetate (a bimodal olfactory-trigeminal stimulus) in a homogeneous sample of 15 healthy, right-handed female subjects. The analysis deals with the contrasts of brain activation patterns between these two odorant conditions. The results showed a significant recruitment of the right insular cortex, and bilaterally in the cingulate in response to the trigeminal component. These findings are discussed in relation to the characteristics of these odorants compared with those tested in previous studies.

Current considerations about Merkel cells.

Since the discovery of Merkel cells by Friedrich S. Merkel in 1875, knowledge of their structure has increased with the progression of new technologies such as electron and laser microscopy, and immunohistochemical techniques. For most vertebrates, Merkel cells are located in the basal layer of the epidermis and characterized by dense-core granules that contain a variety of neuropeptides, plasma membrane spines and cytoskeletal filaments consisting of cytokeratins and desmosomes. The presence of the two latter structures would suggest that Merkel cells originate from the epidermis rather than from the neural crest, even though such a hypothesis is not unanimously accepted. The function of the Merkel cell is also very controversial. For a long time, it has been accepted that Merkel cells with associated nerve terminals act as mechanoreceptors although the transduction mechanism has not yet been elucidated. Merkel cells that do not make contact with nerve terminals have an endocrine function. The present review aims to shed new and comparative light on this field with an attempt to investigate the stimuli that Merkel cells are able to perceive.

Comparative behavioral effects between synthetic 2,4,5-trimethylthiazoline (TMT) and the odor of natural fox (Vulpes vulpes) feces in mice.

Synthetic 2,4,5-trimethylthiazoline (TMT)--a component of red fox (Vulpes vulpes) feces--is frequently used to induce unconditioned fear in rodents. Surprisingly, direct comparison between TMT and natural fox feces odor is almost nonexistent. In this study, Experiment 1 compared the avoidance in relation to TMT concentration, natural fox feces, and gender of fox and mice. Results show that the avoidance is (a) higher with either pure or 50% TMT as compared to natural fox feces, whereas the difference is slight with 10% TMT, and (b) significantly higher for the female mouse group compared to the male mouse group with TMT as well as natural fox feces. In addition, no clear difference in effect was observed between male and female fox feces. Experiment 2 compared behavioral parameters recorded as an index of fear and anxiety, general activity, and avoidance in elevated plus-maze and open-field chamber between 10% TMT and natural fox feces in relation to the estrus cycle of the mice. Results show no cycle period effect--except for the avoidance parameter "distance to odorant"--and no different effects between 10% TMT and natural fox feces except for freezing.

Olfactory/trigeminal interactions in nasal chemoreception.

For a long time, studies devoted to intranasal chemoreception have separately considered the different systems which coexist in the human nasal cavity, especially the olfactory and trigeminal systems. For the former, the findings have contributed to a better understanding of transduction, perception and the treatment of odors. For the latter, data have contributed to the knowledge of somatosensory innervation into the nose, especially in relation to nociception. During the last two decades, an increasing number of studies focused on interactions occurring between both systems. Indeed, most odorant molecules have the propensity to simultaneously stimulate olfactory and trigeminal systems in the nasal cavity. The interactions between both systems appear complex and take place at peripheral, central or perceptual levels. Studies in neurobiology, electrophysiology, psychophysics or functional imaging contribute to determine how both olfactory and trigeminal systems coexist and how one system could influence the other in the treatment of sensory information. However, several structural, functional and methodological questions remain unsolved in the field of olfactory/trigeminal interactions and deserve further research.

Influence of Ambient Odors on Time Perception in a Retrospective Paradigm.

Environmental stimuli can influence time perception, including sensory stimulations. Among them, odors are known to modulate emotion, attention, behavior, or performance, but few studies have investigated the possible effects of ambient odors on time perception. Thus, the present study aimed to compare in a retrospective paradigm the time estimation in three conditions, i.e., with phenyl ethyl alcohol as a pleasant odor, pyridine as unpleasant odor, and a control condition without ambient odor. A total of 90 participants (M age = 23 years, 10 months) took part in three different tasks, i.e., an aesthetic classification task, a sensorimotor checking task, and a mathematical operations task. Results showed a better accuracy of the time estimation in odor condition (1) independently of the characteristics of odorants (2) limited to tasks with a low cognitive involvement. These findings are discussed in relation to the possible role of attention and arousal in the modulation of time perception by ambient odors.

Ambient odors influence the amplitude and time course of visual distraction.

Behavioral performance was examined in a task of attentional capture by luminance under conditions of ambient odors (phenyl ethyl alcohol [PEA], olfactory stimulus, and allyl isothiocyanate [AIC], mixed olfactory/trigeminal stimulus). The AIC increased the amplitude and duration of capture, whereas the presence of PEA led capture to disappear. Furthermore, the PEA caused a general slowing in the speed of information processing. The amplitude and time course of capture were correlated to the irritating components of these odorants, whereas a control experiment showed that the general slowing caused by the PEA was correlated to a drop-off of the subjects' arousal level. These results suggest that ambient odors may exert differential influence of visual-attentional processes and that this influence may depend on the odor's properties.

Trigeminal sensitization and desensitization in the nasal cavity: a study of cross interactions.

Chemical irritation in the human nasal cavity is poorly documented. In this field, an important issue concerns the differential responses produced by successive stimulation. Repeated identical chemical irritant stimuli can produce increases or decreases in responses (two phenomena known as self-sensitization or self-desensitization). In the same way, different molecules can interact and produce cross-sensitization or cross-desensitization. The aim of this study was to contribute to this question using two specific molecules, acetic acid (AA) and allyl isothiocyanate (AIC). As the self-sensitization and -desensitization for AIC is known, a first experiment in the present work investigated the response, acute effects and time course of sensitization or desensitization to acetic acid. A second experiment tested the responses of acetic acid after a previous stimulation with allyl isothiocyanate (mustard oil) and inversely with a short inter-stimulus interval (ISI of 45 s). A third experiment similar to the second used a long inter-stimulus interval (ISI of 3 min 30). Twelve healthy subjects participated in the study using psychophysical (intensity ratings) and psychophysiological (skin conductance response) measurements. Firstly, the results showed that repeated nasal stimulation with acetic acid produced a self-desensitization whatever the ISI. Secondly, the results showed a cross-desensitization of allyl isothiocyanate by previous acetic acid stimulation. In contrast, previous stimulation with allyl isothiocyanate had no effect on the following acetic acid response. These findings confirm that trigeminal sensitization and desensitization in the nasal cavity do not follow the same processes in relation to molecules used.

[Sensory functions and Alzheimer's disease: a multi-disciplinary approach]. / Les fonctions sensorielles et la maladie d'Alzheimer : une approche multidisciplinaire.

Relations between sensory functions and Alzheimer's disease are still under-explored. To understand them better, the Fondation Médéric Alzheimer has brought together a multi-disciplinary expert group. Aristote's five senses must be enhanced by today's knowledge of proprioception, motor cognition and pain perception. When cognition breaks down, the person with dementia perceives the world around her with her sensory experience, yet is unable to integrate all this information to understand the context. The treatment of multiple sensory inputs by the brain is closely linked to cognitive processes. Sensory deficits reduce considerably the autonomy of people with dementia in their daily life and their relations with others, increase their social isolation and the risk of accidents. Professionals involved with neurodegenerative diseases remain poorly aware of sensory deficits, which can bias the results of cognitive tests. However, there are simple tools to detect these deficits, notably for vision, hearing and balance disorders, which can be corrected. Many interventions for cognitive rehabilitation or quality of life improvement are based on sensory functions. The environment of people with dementia must be adapted to become understandable, comfortable, safe and eventually therapeutic.

Unconscious odor detection could not be due to odor itself.

Unconscious odor detection has been demonstrated but the mechanisms implied in this process have been poorly studied. In so far, most odorants activate both olfactory and trigeminal systems, it is relevant to explore how each system could be involved in the unconscious detection processes. This study used three methods to determine the detection thresholds for three odorants. The results showed that (1). psychophysical were lower than self-evaluated thresholds whatever the odorant; (2). an odorant with trigeminal component had the ability to produce an autonomic (skin conductance response-SCR) activation with lower concentrations than psychophysical and self-evaluated thresholds; on the contrary, an odorant, which stimulates only the olfactory system, induces an autonomic activation only with higher concentrations than psychophysical and self-evaluated thresholds. These findings suggest that unconscious odor detection could be due to the trigeminal component of odorants.

Effects of ambient odors on reaction time in humans.

The perception of odors is well identified as having strong emotional correlates. The effects of ambient odors on arousal level and task performance have also been suspected but remain poorly assessed in the literature. The present study compared the reaction times of subjects between ambient odor conditions (pleasant and unpleasant) and a no-odor condition. The results showed that the reaction time in simple tasks (responses to visual or auditory stimulation) significantly decreased in the ambient odor conditions (whatever the pleasantness of the odors) compared with the no-odor condition. These results underline the importance of the olfactory environment in human behavior.

Ambient odors modulate visual attentional capture.

Sudden visual events capture attention involuntarily because they may signal potential threats. Some theoretical accounts consider that the biological significance of these events is established through the limbic structures. Thus, the manipulation of the limbic activity would affect attentional capture. Since these structures are directly linked to the olfactory system, we have tended to modulate their activity with olfactory stimulations. We have examined behavioral performance in a task of attentional capture by luminance under conditions of ambient odors. Our results show that attentional capture is indeed modulated by ambient odors, and that this modulation may depend on the odor's properties.

Influence of nasal trigeminal stimuli on olfactory sensitivity.

In the nose, the capacity to detect and react to volatile chemicals is mediated by two separate but interrelated sensory pathways, the olfactory and trigeminal systems. Because most chemosensory stimulants, at sufficient concentration, produce both olfactory and trigeminal sensations (i.e., stinging, burning or pungent), it is relevant to seek how these anatomically distinct systems could interact. This study was designed to evaluate by psychophysical measurements the modifications of the olfactory sensitivity of 20 subjects to phenyl ethyl alcohol (PEA) and butanol (BUT), after trigeminal stimulation with allyl isothiocyanate (AIC). Thresholds obtained in two separate sessions, one with and the other without previous trigeminal stimulation, were compared using a two-alternative forced-choice procedure, with a classical ascending concentrations method. The results showed that, whatever the odorant (PEA or BUT), AIC trigeminal activation produced a decrease in the olfactory thresholds, corresponding to an increase in olfactory sensitivity. These data confirm that in physiological conditions the trigeminal system modulates the activity of olfactory receptor cells but do not exclude the possibility of a central modulation of olfactory information by trigeminal stimuli. These findings are discussed in terms of methodological and physiological conditions.

Left:right differences in psychophysical and electrodermal measures of olfactory thresholds and their relation to electrodermal indices of hemispheric asymmetries.

The study of lateralization processes in olfaction in human subjects has given rise to many contradictory findings. Indeed, sensorial cerebral asymmetry in olfaction depends on several factors (nature of task, quality of stimulus, characteristics of subjects, etc.) and could be also related to differences between the nostrils. In this field, few studies have assessed simultaneously the left-right nostril differences and the hemispheric asymmetry. The present work dealt with this question in the same population with the same odorants, procedures, and stimulations. Seven different concentrations of four specific odorants (two pleasant and two unpleasant) were used by single nostril stimulation with 30 dextral subjects (20 women and 10 men). Threshold detection in unilateral stimulation was investigated using electrodermal response to confirm the first psychophysic measure. Moreover, bilateral recordings of electrodermal activity (EDA) with unilateral stimulation were used as a measure of functional hemispheric asymmetry. Analysis showed no differences between the two nostrils for the threshold detection regardless of the method used (psychophysic or EDA response). However, most subjects presented a constant direction of electrodermal asymmetry whichever nostril was stimulated and whichever odorant stimulus used. The constant bilateral differences in EDA recordings are discussed in terms of asymmetrical activation of the hemispheres.

Transitivity of odor preferences: constant and particularities in hedonic perception.

Transitivity of preferences has been investigated for a long time in decision-making. In the field of perception, the pleasantness of odors raises several questions related to individual versus cultural or universal preferences and the existence of a classification in a delimited hedonic space. The aim of this study was to test transitivity in olfactory hedonicity using a first panel of 10 mixed odors and a second panel of 10 odors from a delimited floral category. Data were collected by paired comparisons in a two-alternative forced choice. Results in both panels showed a strong transitivity for each participant leading to a linear range of 10 odors classified by preference. However, ranges varied from one participant to another and the mean preferences of the group did not allow one to infer individual's hedonic classification of odors. Moreover, the individual classification appeared stable over time and undisturbed by odorant distractors. These findings suggest that humans have considerable ability to classify odors hedonically as a model of individual preferences in a sensory space usually considered to be more involved in affective/emotional states than in cognitive performances.