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1.
Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant.
Bioorg Med Chem Lett
; 21(12): 3743-8, 2011 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21561767
2.
Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant.
J Med Chem
; 53(12): 4701-19, 2010 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-20513156
3.
9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.
J Med Chem
; 52(15): 4743-56, 2009 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-19572547
4.
Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible.
Drug Metab Dispos
; 32(1): 105-12, 2004 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-14709627
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