Real-world data on T-DM1 efficacy - results of a single-center retrospective study of HER2-positive breast cancer patients.

T-DM1 is an antibody drug conjugate that combines trastuzumab with emtansine via a stable thioether linker. In two phase III clinical trials, EMILIA and TH3RESA, T-DM1 was shown to be effective in HER2-positive metastatic breast cancer patients who had progressed to taxanes and trastuzumab. We have performed a real-world study to complement the findings of the clinical trials. From 2012 to 2016, 15 patients with HER2-positive breast cancer who had progressed to prior treatment received T-DM1 at our center. We have retrospectively analyzed outcomes in these patients and compared our findings with those of the two clinical trials. Progression-free survival (PFS) was 10 months compared with the 9.6 months of the EMILIA trial and the 6.2 months of the TH3RESA trial, overall survival was 34 months compared with the 29.9 months of the EMILIA trial and the 22.7 months of the TH3RESA trial. PFS was ≥12 months in five patients, three of whom attained a PFS of ≥23 months. Among five patients with metastases of the central nervous system, PFS was six months, OS was not reached, and the objective response rate was 80%. Our findings are in line with those of the EMILIA study and slightly superior to those of the TH3RESA study. In our series of patients, T-DM1 has demonstrated efficacy in the treatment of HER2-positive metastatic breast cancer. Our real-world data thus confirm and support the findings of the two major phase III trials and indicate the usefulness of T-DM1 in routine clinical practice.

Abordaje teórico en el estudio de las conductas sexuales de riesgo en la adolescencia / Theoretical approach to the study of sexual risk behaviors in adolescence

RESUMEN Introducción: las conductas sexuales de riesgo favorecen la presencia de riesgos que afectan la salud sexual y reproductiva de los/as adolescentes, además de su desarrollo psicológico y social. Estas conductas pueden constituirse en importantes problemas de salud para los/as adolescentes en Consolación del Sur. Objetivo: analizar los principales elementos teóricos que se abordan en la literatura nacional e internacional sobre las conductas sexuales de riesgo por su importancia en la adolescencia. Métodos: se realizó un estudio descriptivo a partir de una revisión bibliográfica de los principales artículos científicos de los últimos años, utilizando las bases de datos SciELO, LILACS, revistas biomédicas nacionales e internacionales y otras fuentes bibliográficas que incluyeron Dialnet y Google Académico. Se utilizaron como métodos del nivel teórico, el histórico-lógico, análisis-síntesis e inductivo-deductivo que permitieron el análisis de los diversos enfoques sobre el tema. Resultados: las conductas sexuales de riesgo afectan la salud sexual y reproductiva. Los factores de riesgo y los factores protectores influyen en el comportamiento sexual de los/as adolescentes. Las acciones preventivas favorecen la formación de adolescentes más responsables y la creación de ambientes favorables como una vía para lograr cambios hacia conductas sexuales más sanas. Conclusiones: El presente artículo permite la reflexión acerca de las conductas sexuales de riesgo y contribuye a la comprensión de aspectos importantes sobre el tema.

ABSTRACT Introduction: risky sexual behaviors favor the presence of risks that affect sexual and reproductive health of adolescents, as well as their psychological and social development. These behaviors can turn out to be significant health problems for adolescents in Consolación del Sur municipality. Objective: to analyze the main theoretical elements dealing with this topic in the national and international literature on risky sexual behaviors due to their importance in adolescence. Methods: a descriptive study was carried out based on a bibliographic review of the main scientific articles of recent years, using SciELO, LILACS databases, national and international biomedical journals and other bibliographic sources that included Dialnet and Google Academic. Methods from the theoretical level such as: historical-logical, analysis-synthesis and inductive-deductive were applied, making possible the analysis of the different approaches on the area under discussion. Results: sexual risk behaviors affect sexual and reproductive health. Risk and protective factors influence on the sexual behavior of adolescents. Preventive actions favor the development of more responsible adolescents and the creation of favorable environments as main actions to achieve changes toward healthier sexual behaviors. Conclusions: this article provides indications on risky sexual behaviors and contributes to the understanding of important aspects concerning this issue.