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1.
Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.
Bioorg Med Chem
; 20(6): 1961-72, 2012 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22137930
2.
Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail.
Mol Cell Biol
; 27(8): 3165-75, 2007 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-17296734
3.
Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase.
Bioorg Med Chem Lett
; 20(17): 5027-30, 2010 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20675137
4.
Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.
Bioorg Med Chem Lett
; 20(10): 3182-5, 2010 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20399649
5.
SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.
Bioorg Med Chem Lett
; 20(5): 1744-8, 2010 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20153189
6.
BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells.
Clin Cancer Res
; 15(1): 226-37, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19118050
7.
BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide.
Gynecol Oncol
; 115(2): 193-8, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19699512
8.
HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924.
Mol Cancer Ther
; 7(9): 2589-98, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18765823
9.
2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924.
Bioorg Med Chem Lett
; 18(5): 1702-7, 2008 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18258427
10.
Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors.
Bioorg Med Chem Lett
; 18(14): 4075-80, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18572407
11.
In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.
Cancer Res
; 66(1): 362-71, 2006 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16397250
12.
Induction of ornithine decarboxylase activity is a necessary step for mitogen-activated protein kinase kinase-induced skin tumorigenesis.
Cancer Res
; 65(2): 572-8, 2005 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15695401
13.
Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor.
Cancer Res
; 65(9): 3781-7, 2005 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15867374
14.
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
J Med Chem
; 48(18): 5639-43, 2005 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-16134929
15.
IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines.
Mol Cancer Ther
; 14(2): 620-30, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25527633
16.
IGFBP ratio confers resistance to IGF targeting and correlates with increased invasion and poor outcome in breast tumors.
Clin Cancer Res
; 18(6): 1808-17, 2012 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22287600
17.
IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein.
Exp Hematol
; 40(9): 715-723.e6, 2012 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-22613471
18.
Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways.
PLoS One
; 7(12): e51189, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-23300537
19.
IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer.
Endocr Relat Cancer
; 18(6): 699-709, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21946410
20.
ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway.
Cancer Res
; 71(3): 1060-70, 2011 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21148487