Running Functional Threshold versus Critical Power: Same Concept but Different Values.

The aims of this study were (i) to estimate the functional threshold power (FTP) and critical power (CP) from single shorter time trials (TTs) (i. e. 10, 20 and 30 minutes) and (ii) to assess their location in the power-duration curve. Fifteen highly trained athletes randomly performed ten TTs (i. e. 1, 2, 3, 4, 5, 10, 20, 30, 50 and 60 minutes). FTP was determined as the mean power output developed in the 60-min TT, while CP was estimated in the running power meter platform according to the manufacturer's recommendations. The linear regression analysis revealed an acceptable FTP estimate for the 10, 20 and 30-min TTs (SEE≤12.27 W) corresponding to a correction factor of 85, 90 and 95%, respectively. An acceptable CP estimate was only observed for the 20-min TT (SEE=6.67 W) corresponding to a correction factor of 95%. The CP was located at the 30-min power output (1.0 [-5.1 to 7.1] W), which was over FTP (14 [7.0 to 21] W). Therefore, athletes and practitioners concerned with determining FTP and CP through a feasible testing protocol are encouraged to perform a 20-min TT and apply a correction factor of 90 and 95%, respectively.

Wearable and Portable Devices in Sport Biomechanics and Training Science.

Sport biomechanics and training have traditionally been tested under laboratory conditions, requiring specific settings and expensive equipment [...].

Training Specificity in Trail Running: A Single-Arm Trial on the Influence of Weighted Vest on Power and Kinematics in Trained Trail Runners.

Participants in trail running races must carry their equipment throughout the race. This additional load modifies running biomechanics. Novel running powermeters allow further analyses of key running metrics. This study aims to determine the acute effects of running with extra weights on running power generation and running kinematics at submaximal speed. Fifteen male amateur trail runners completed three treadmill running sessions with a weighted vest of 0-, 5-, or 10% of their body mass (BM), at 8, 10, 12, and 14 km·h-1. Mean power output (MPO), leg spring stiffness (LSS), ground contact time (GCT), flight time (FT), step frequency (SF), step length (SL), vertical oscillation (VO), and duty factor (DF) were estimated with the Stryd wearable system. The one-way ANOVA revealed higher GCT and MPO and lower DF, VO, and FT for the +10% BM compared to the two other conditions (p < 0.001) for the running speeds evaluated (ES: 0.2-7.0). After post-hoc testing, LSS resulted to be higher for +5% BM than for the +10% and +0% BM conditions (ES: 0.2 and 0.4). Running with lighter loads (i.e., +5% BM) takes the principle of specificity in trail running one step further, enhancing running power generation and LSS.

Level of Agreement between the MotionMetrix System and an Optoelectronic Motion Capture System for Walking and Running Gait Measurements.

Markerless motion capture systems (MCS) have been developed as an alternative solution to overcome the limitations of 3D MCS as they provide a more practical and efficient setup process given, among other factors, the lack of sensors attached to the body. However, this might affect the accuracy of the measures recorded. Thus, this study is aimed at evaluating the level of agreement between a markerless MSC (i.e., MotionMetrix) and an optoelectronic MCS (i.e., Qualisys). For such purpose, 24 healthy young adults were assessed for walking (at 5 km/h) and running (at 10 and 15 km/h) in a single session. The parameters obtained from MotionMetrix and Qualisys were tested in terms of level of agreement. When walking at 5 km/h, the MotionMetrix system significantly underestimated the stance and swing phases, as well as the load and pre-swing phases (p < 0.05) reporting also relatively low systematic bias (i.e., ≤ -0.03 s) and standard error of the estimate (SEE) (i.e., ≤0.02 s). The level of agreement between measurements was perfect (r > 0.9) for step length left and cadence and very large (r > 0.7) for step time left, gait cycle, and stride length. Regarding running at 10 km/h, bias and SEE analysis revealed significant differences for most of the variables except for stride time, rate and length, swing knee flexion for both legs, and thigh flexion left. The level of agreement between measurements was very large (r > 0.7) for stride time and rate, stride length, and vertical displacement. At 15 km/h, bias and SEE revealed significant differences for vertical displacement, landing knee flexion for both legs, stance knee flexion left, thigh flexion, and extension for both legs. The level of agreement between measurements in running at 15 km/h was almost perfect (r > 0.9) when comparing Qualisys and MotionMetrix parameters for stride time and rate, and stride length. The agreement between the two motion capture systems varied for different variables and speeds of locomotion, with some variables demonstrating high agreement while others showed poor agreement. Nonetheless, the findings presented here suggest that the MotionMetrix system is a promising option for sports practitioners and clinicians interested in measuring gait variables, particularly in the contexts examined in the study.

Effect of intra-session exercise sequence of an 8-week concurrent training program on the components of physical fitness in recreationally trained young adults.

This study aimed to determine the effect of the intra-session exercise sequence of a concurrent training programme on the components of health-related physical fitness. Twenty-four healthy young adults were allocated into two different groups differing only in the exercise order to conduct an 8-week intra-session concurrent training programme consisting of three sessions of 60-90 minutes (180-270 min/week), with all-out running sprint intervals, back squat, and bench press endurance and resistance exercises (i.e., ET+RT and RT+ET). The 8-week intra-session concurrent training programme overall improved all the components of physical fitness regardless of the exercise sequence. However, ET + RT and RT + ET groups reported moderate and small improvements for squat jump (ET + RT: 3.82 cm [1.11 to 6.53 cm]; RT + ET: 0.31 cm [-1.72 to 2.33 cm]), countermovement jump (ET + RT: 3.76 cm [1.43 to 6.08 cm]; RT + ET: 2.07 cm [-0.03 to 4.17 cm]) and maximum oxygen uptake (ET + RT: 4.75 ml/kg/min [1.14 to 8.35 ml/kg/min]; RT + ET: 1.66 ml/kg/min [-0.89 to 4.21 ml/kg/min]), respectively. Therefore, greater lower-body power and cardiorespiratory fitness gains might be induced following the ET + RT sequence.

Influence of footwear, foot-strike pattern and step frequency on spatiotemporal parameters and lower-body stiffness in running.

This study aimed to determine the influence of footwear condition, foot-strike pattern and step frequency on running spatiotemporal parameters and lower-body stiffness during treadmill running. Thirty-one amateur endurance runners performed a two-session protocol (shod and barefoot). Each session consisted of two trials at 12 km · h-1 over 5 minutes altering step frequency every minute (150, 160, 170, 180 and 190 spm). First, participants were instructed to land with the heel first; after completion, the same protocol was repeated landing with the forefoot first. Repeated measures ANOVAs showed significant differences for footwear condition, foot-strike pattern and step frequency for each variable: percent contact time, percent flight time, vertical stiffness and leg stiffness (all p < 0.001). The results demonstrate greater estimated vertical and leg stiffness when running barefoot for both foot-strike patterns showing the largest values for barefoot+forefoot condition. Likewise, both vertical and leg stiffness became greater as step frequency increased. The proper manipulation of these variables facilitates our understanding of running performance and assist in training programmes design and injury management.

Test-Retest Reliability of the MotionMetrix Software for the Analysis of Walking and Running Gait Parameters.

The use of markerless motion capture systems is becoming more popular for walking and running analysis given their user-friendliness and their time efficiency but in some cases their validity is uncertain. Here, the test-retest reliability of the MotionMetrix software combined with the use of Kinect sensors is tested with 24 healthy volunteers for walking (at 5 km·h−1) and running (at 10 and 15 km·h−1) gait analysis in two different trials. All the parameters given by the MotionMetrix software for both walking and running gait analysis are tested in terms of reliability. No significant differences (p > 0.05) were found for walking gait parameters between both trials except for the phases of loading response and double support, and the spatiotemporal parameters of step length and step frequency. Additionally, all the parameters exhibit acceptable reliability (CV < 10%) but step width (CV > 10%). When analyzing running gait, although the parameters here tested exhibited different reliability values at 10 km·h−1, the system provided reliable measurements for most of the kinematic and kinetic parameters (CV < 10%) when running at 15 km·h−1. Overall, the results obtained show that, although some variables must be interpreted with caution, the Kinect + MotionMetrix system may be useful for walking and running gait analysis. Nevertheless, the validity still needs to be determined against a gold standard system to fully trust this technology and software combination.

Influence of the Shod Condition on Running Power Output: An Analysis in Recreationally Active Endurance Runners.

Several studies have already analysed power output in running or the relation between VO2max and power production as factors related to running economy; however, there are no studies assessing the difference in power output between shod and barefoot running. This study aims to identify the effect of footwear on the power output endurance runner. Forty-one endurance runners (16 female) were evaluated at shod and barefoot running over a one-session running protocol at their preferred comfortable velocity (11.71 ± 1.07 km·h−1). The mean power output (MPO) and normalized MPO (MPOnorm), form power, vertical oscillation, leg stiffness, running effectiveness and spatiotemporal parameters were obtained using the Stryd™ foot pod system. Additionally, footstrike patterns were measured using high-speed video at 240 Hz. No differences were noted in MPO (p = 0.582) and MPOnorm (p = 0.568), whereas significant differences were found in form power, in both absolute (p = 0.001) and relative values (p < 0.001), running effectiveness (p = 0.006), stiffness (p = 0.002) and vertical oscillation (p < 0.001). By running barefoot, lower values for contact time (p < 0.001) and step length (p = 0.003) were obtained with greater step frequency (p < 0.001), compared to shod running. The prevalence of footstrike pattern significantly differs between conditions, with 19.5% of runners showing a rearfoot strike, whereas no runners showed a rearfoot strike during barefoot running. Running barefoot showed greater running effectiveness in comparison with shod running, and was consistent with lower values in form power and lower vertical oscillation. From a practical perspective, the long-term effect of barefoot running drills might lead to increased running efficiency and leg stiffness in endurance runners, affecting running economy.

Estimating Functional Threshold Power in Endurance Running from Shorter Time Trials Using a 6-Axis Inertial Measurement Sensor.

Wearable technology has allowed for the real-time assessment of mechanical work employed in several sporting activities. Through novel power metrics, Functional Threshold Power have shown a reliable indicator of training intensities. This study aims to determine the relationship between mean power output (MPO) values obtained during three submaximal running time trials (i.e., 10 min, 20 min, and 30 min) and the functional threshold power (FTP). Twenty-two recreationally trained male endurance runners completed four submaximal running time trials of 10, 20, 30, and 60 min, trying to cover the longest possible distance on a motorized treadmill. Absolute MPO (W), normalized MPO (W/kg) and standard deviation (SD) were calculated for each time trial with a power meter device attached to the shoelaces. All simplified FTP trials analyzed (i.e., FTP10, FTP20, and FTP30) showed a significant association with the calculated FTP (p < 0.001) for both MPO and normalized MPO, whereas stronger correlations were found with longer time trials. Individual correction factors (ICF% = FTP60/FTPn) of ~90% for FTP10, ~94% for FTP20, and ~96% for FTP30 were obtained. The present study procures important practical applications for coaches and athletes as it provides a more accurate estimation of FTP in endurance running through less fatiguing, reproducible tests.

[Update on neuroendocrine tumors]. / Tumores Neuroendocrinos: un desafío transversal.

Neuroendocrine Tumors (NETs) encompass a wide variety of tumors arising from neuroendocrine cells, which produce bioactive substances. The incidence of NETs increased significantly lately, becoming one of the most common tumors of the digestive tract. Their clinical presentation is as diverse as their capacity for hormone production. Carcinoid syndrome is the most common hormonal syndrome produced by NETs and is characterized by diarrhea, flushing and cardiac valvular lesions. New research brought multiple changes in the classification of these neoplasms and a new understanding about their diagnosis and treatment, promoting a multidisciplinary approach. Somatostatin analogues, radiation, biological, and cytotoxic drugs have improved the prognosis of these patients, which entails a great challenge for healthcare providers.

Mechanical Power in Endurance Running: A Scoping Review on Sensors for Power Output Estimation during Running.

Mechanical power may act as a key indicator for physiological and mechanical changes during running. In this scoping review, we examine the current evidences about the use of power output (PW) during endurance running and the different commercially available wearable sensors to assess PW. The Boolean phrases endurance OR submaximal NOT sprint AND running OR runner AND power OR power meter, were searched in PubMed, MEDLINE, and SCOPUS. Nineteen studies were finally selected for analysis. The current evidence about critical power and both power-time and power-duration relationships in running allow to provide coaches and practitioners a new promising setting for PW quantification with the use of wearable sensors. Some studies have assessed the validity and reliability of different available wearables for both kinematics parameters and PW when running but running power meters need further research before a definitive conclusion regarding its validity and reliability.

Global Positioning System Analysis of Physical Demands in Small and Large-Sided Games with Floaters and Official Matches in the Process of Return to Play in High Level Soccer Players.

The aim of this study was twofold: (i) to analyze the physical demands in the return to play (RTP) process of high-level soccer players in the role of floater in different soccer sided games (SGs) formats (i.e., 4vs4 + 2 and 8vs8 + 1); and (ii) to analyze the differences in physical demands encountered by regular and floater players among the SGs formats and official matches by means of global positioning system technology (GPS APEX pod, North Ireland) was used. Twenty-six highly trained, male soccer players (U16 years) participated in this investigation. Players were classified into two groups: 23 regular and 3 floater players, a total of eight SGs were analyzed, which involved the recording of 80 observations of regular and floater players. Match-play players showed most likely-probable differences in distance covered at high-intensity per minute (D > 14.4/min), at high-speed running per minute (D > 21/min), and peak velocity (Vpeak) in comparison to floaters in the 8vs8 + 1 LSG (large-side-games), and presented most likely differences in accelerations >2/min in comparison to match-play players. Therefore, the use of floaters during the last phase of the RTP (return to play) seems to be a useful strategy for progressive reintroduction into specific training (1) floater in the 4vs4 + 2 SSG; (2) floater in the 8vs8 + 1 LSG; (3) regular player in the 4vs4 + 2 SSG; and (4) regular player in the 8vs8 + 1 LSG before starting full trainings and returning to competition.

[Papillary thyroid carcinoma in a child with congenital dyshormonogenetic hypothyroidism. Case report]. / Carcinoma papilar de tiroides en un niño con hipotiroidismo congénito dishormonogénico. Reporte de un caso.

INTRODUCTION: Papillary thyroid carcinoma (PTC) is a rare childhood disease. The development of PTC in dyshormonogenetic congenital hypothyroidism (CH) is infrequent, with very few case reports in literature. OBJECTIVE: To report a case of PTC in a boy with dyshormonogenetic CH without goitre and exposed to ionising radiation. To evaluate relationships between these factors and development of PTC. CASE REPORT: We present a boy with dyshormonogenetic CH since birth. Early hormonal substitution was initiated, with subsequent normal levels of thyrotropin and thyroid hormones. He has also congenital cardiomyopathy, exposed to interventional treatment with 10 heart catheterisations, and approximately 26 chest X-rays at paediatric doses. A thyroid nodule was found in thyroid echography at the age of 6 years old. Fine needle aspiration biopsy confirmed high probability of thyroid carcinoma (Bethesda 5). The pre-surgical thorax and cerebral scan showed no evidence of metastasis. The patient underwent total thyroidectomy. Pathological examination revealed a 0.5cm papillary thyroid micro-carcinoma in the right lobe, with no evidence of dissemination. CONCLUSION: Genetic mutations and radiation exposure may play an important role in the development of PTC. There may be common pathways between dyshormonogenetic CH and thyroid carcinoma that need further investigation.

Human papillomavirus infection in oral squamous cell carcinomas from Chilean patients.

Human papillomavirus (HPV) is the causal agent of cervical, anogenital and a subset of oropharyngeal carcinomas. In addition, the role of HPV in oral carcinogenesis has been suggested, although the findings are inconclusive. In this study, using conventional polymerase chain reaction (PCR) and genotyping by specific PCR and DNA sequencing, we analyzed the HPV presence in 80 oral squamous cell carcinomas (OSCCs) from Chilean subjects. In addition, we determined the expression of p16, p53, pRb and Ki-67 using immunohistochemistry (IHC). The CDKN2A (p16) promoter methylation was evaluated using methylation-specific PCR (MSP). HPV sequences were found in 9/80 (11%) OSCCs. Non-statistically significant association with p53, pRb, Ki-67 and p16 levels were found (p=0.77; 0.29; 0.83; 0.21, respectively). HPV-16 and 18 were the most prevalent HPV genotypes in 8/9 (89%) OSCCs. In addition, CDKN2A (p16) was methylated in 39% of OSCCs. No association with HPV presence (p=0.917) was found. These results suggest that HPV positive OSCCs are entities that do not resemble the molecular alterations of HPV-associated tumors in a Chilean population. More studies are warranted to determine the role of HPV in OSCCs.

[Diagnostic yield of fine-needle aspiration cytology for the detection of thyroid cancer in pediatric patients]. / Concordancia de la citología por punción con aguja fina para la detección de cáncer de tiroides en pediatría.

BACKGROUND: Despite the low frequency of thyroid nodules (TN) in children, one of every four is malignant. Fine-needle aspiration cytology (FNAC) has a high accuracy detecting thyroid cancer. AIM: To evaluate the performance of FNAC in TN in Chilean children to detect thyroid cancer. PATIENTS AND METHODS: The pathological reports of 77 thyroidectomies and 103 FNAC carried out in patients aged less than 18 years, between 2002 and 2013 were reviewed. In 36 patients aged 15 ± 2 years (77% women), both the reports of the thyroidectomy and FNAC were available. The cytological specimens were reclassified based on Bethesda 2010. The histology was classified as benign (nodular hyperplasia and follicular adenoma, n = 18), or malignant (papillary, follicular and medullar carcinoma, n = 18). The concordance of the cytology with the final biopsy report was calculated. RESULTS: FNAC classified 13 specimens as definitively benign and 13 as definitively malignant. Among these, these concordances with the pathological study of the biopsy was 100%. Of six cytology tests considered "suspicious for follicular neoplasm" by FNAC, four were benign (67%), and two malignant (33%). Of four cytology tests considered "suggestive of carcinoma" by FNAC, one was benign (25%), and three malignant (75%). CONCLUSIONS: Among the studied children, there was a good concordance between FNAC and surgical biopsies. Therefore a FNAC should be carried out when malignancy is suspected in pediatric patients with a TN.

[Nosocomial infections after cardiac surgery in infants and children with congenital heart disease]. / Infecciones asociadas a la atención en salud (IAAS) en pacientes pediátricos post-operados de cardiopatías congénitas.

INTRODUCTION: Nosocomial infections generate high morbidity and mortality in children undergoing cardiac surgery. OBJECTIVE: To determine risk factors for nosocomial infections in children after congenital heart surgery. METHODS: A retrospective case-control study, in patients younger than 15 years undergoing surgery for congenital heart disease from January 2007 to December 2011 admitted to the Pediatric Critical Patient Unit (UPC-P) in a university hospital. For cases, the information was analyzed from the first episode of infection. RESULTS: 39 patients who develop infections and 39 controls who did not develop infection were enrolled. The median age of cases was 2 months. We identified a number of factors associated with the occurrence of infections, highlighting in univariate analysis: age, weight, univentricular heart physiology, complexity of the surgical procedure according to RACHS-1 and cardiopulmonary bypass (CPB) time ≥ 200 minutes. Multivariate analysis identified CPB time ≥ 200 minutes as the major risk factor, with an OR of 11.57 (CI: 1.04 to 128.5). CONCLUSION: CPB time ≥ 200 minutes was the mayor risk factor associated with the development of nosocomial infections.

High power illumination system for uniform, isotropic and real time controlled irradiance in photoactivated processes research.

In the study of photocatalytic and photoactivated processes and devices a tight control on the illumination conditions is mandatory. The practical challenges in the determination of the necessary photonic quantities pose serious difficulties in the characterization of catalytic performance and reactor designs and configurations, compromising an effective comparison between different experiments. To overcome these limitations, we have designed and constructed a new illumination system based in the concept of the integrating sphere (IS). The system provides uniform and isotropic illumination on the sample, either in batch or continuous flow modes, being these characteristics independent of the sample geometry. It allows direct, non-contact and real time determination of the photonic quantities as well as versatile control on the irradiance values and its spectral characteristics. It can be also scaled up to admit samples of different sizes without affecting its operational behaviour. The performance of the IS system has been determined in comparison with a second illumination system, mounted on an optical bench, that provides quasi-parallel beam (QPB) nearly uniform illumination in tightly controlled conditions. System performance is studied using three sample geometries: a standard quartz cuvette, a thin straight tube and a microreactor by means of potassium ferrioxalate actinometry. Results indicate that the illumination geometry and the angular distribution of the incoming light greatly affect the absorption at the sample. The sample light absorption efficiency can be obtained with statistical uncertainties of about 3% and in very good agreement with theoretical estimations.

Green Flame-Retardant Blend Used to Improve the Antiflame Properties of Polypropylene.

The flammability properties of polymers and polymeric composites play an important role in ensuring the safety of humans and the environment; moreover, flame-retardant materials ensure a greater number of applications. In the present study, we report the obtaining of polypropylene (PP) composites contain a mixture of two green flame retardants, lignin and clinoptilolite, by melt extrusion. These additives are abundantly found in nature. Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), mechanical properties, scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS), cone calorimetry, UL-94, and carbonized residues analysis were carried out. TGA analysis shows that PPGFR-10 and PPGFR-20 compounds presented better thermal stability with respect to PP without flame retardants. The conical calorimetric evaluation of the composites showed that PPGFR-10 and PPGFR-20 presented decreases in peak heat release rates (HRRs) of 9.75% and 11.88%, respectively. The flammability of the composites was evaluated with the UL-94 standard, and only the PPGFR-20 composite presented the V-0 and 5VB classification, which indicates good flame-retardant properties. Additives in the polymer matrix showed good dispersion with few agglomerates. The PPGFR-20 composite showed an FRI value of 1.15, higher percentage of carbonized residues, and UL-94 V-0 and 5VB rating, suggesting some kind of synergy between lignin and clinoptilolite, but only at high flame-retardant concentrations.

Larger Achilles and plantar fascia induce lower duty factor during barefoot running.

OBJECTIVES: Tendons play a crucial role allowing the storage and release of mechanical energy during the running cycle. Running kinematics, including duty factor, constitute a basic element of the runner's biomechanics, and can determine their performance. This study aimed to analyze the link between Achilles tendon and plantar fascia morphology and running parameters, considering the influence of wearing shoes versus running barefoot. DESIGN: Cross-sectional study. METHODS: 44 participants (30 men and 14 women) engaged in two running sessions, one with shoes and one without, both lasting 3 min at a consistent speed of 12 km/h. We captured running kinematic data using a photoelectric cell system throughout the sessions. Before the trials, we measured the thickness and cross-sectional area of both the Achilles tendon and plantar fascia using ultrasound. RESULTS: The Pearson test revealed a significant correlation (p < 0,05) between Achilles tendon and plantar fascia morphology and contact time (r > -0.325), flight time (r > -0.325) and duty factor (ratio of ground contact to stride time) (r > -0.328) during barefoot running. During the shod condition, no significant correlation was found between connective tissue morphology and kinematic variables. CONCLUSIONS: In barefoot running, greater size of the Achilles tendon and plantar fascia results in a reduced duty factor, attributed to longer flight times and shorter contact times.