RESUMEN
The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays an important role on the course of disease in familial Mediterranean fever (FMF). TNF-alpha gene promoter polymorphism may be a marker of susceptibility and severity of FMF. The aim of this study is to evaluate both TNF-alpha/238 and TNF-alpha/308 genotypes and allelic distribution in patients with FMF. Forty-one FMF patients and 43 healthy volunteers were included in the study. Genomic DNA was extracted from EDTA-preserved whole blood of whole series of patients and controls. Polymorphism of TNF-alpha promoter at positions -238 and -308 were detected by using amplification refractory mutation system polymerase chain reaction. TNF-alpha/238 and TNF-alpha/308 genotype distributions and allele frequencies of FMF patients and healthy volunteers were found to be similar. Moreover, there was no association between TNF-alpha/238 and TNF-alpha/308 genotypes and the frequency of acute attacks in FMF. TNF-alpha/238 and TNF-alpha/308 promoter polymorphisms do not seem to be major genetic risk factors for susceptibility to FMF and severity of the disease.
Asunto(s)
Fiebre Mediterránea Familiar/genética , Polimorfismo de Nucleótido Simple/genética , Regiones Promotoras Genéticas/genética , Factor de Necrosis Tumoral alfa/genética , Adulto , Estudios de Casos y Controles , Fiebre Mediterránea Familiar/inmunología , Femenino , Genotipo , Humanos , Masculino , Persona de Mediana EdadRESUMEN
We report a 55-year-old man with a white plaque-like lesion 4 mm in diameter located in the rectum on colonoscopic examination. Biopsy specimens showed carcinoid tumor. Endoscopic submucosal resection (ESMR) of the lesion was successfully performed by using cap aspiration-snare resection method.
Asunto(s)
Tumor Carcinoide/cirugía , Proctoscopía/métodos , Neoplasias del Recto/cirugía , Humanos , Ligadura/instrumentación , Masculino , Persona de Mediana EdadRESUMEN
UNLABELLED: The acute effect of ethanol intake on the upper gastrointestinal system is not clearly known. Animal studies have shown that ethanol inhibited the antral muscle fiber contractions and slow wave activity. BACKGROUND/AIMS: To show the acute effect of oral ethanol intake on gastric myoelectrical activity in healthy volunteers. METHODS: Fourteen healthy male volunteers were included in the study. They were given control solution with test meal and ethanol with test meal on two different days. Electrogastrography recordings were obtained in pre-/postprandial periods. RESULTS: On the days of ethanol intake, blood alcohol level reached above 80 mg/dl in 10 volunteers. Ethanol intake did not show any significant effect on any of the electrogastrography parameters. CONCLUSIONS: Though reasonable blood alcohol level was achieved and six volunteers experienced upper gastrointestinal system complaints, ethanol had no effect on gastric myoelectrical activity.