Delays in radical cystectomy for muscle-invasive bladder cancer.

BACKGROUND: Delays from the diagnosis of muscle-invasive bladder cancer (MIBC) to radical cystectomy (RC) longer than 12 weeks result in higher mortality and shorter progression-free survival. This study sought to identify factors associated with RC delays and to determine whether delays in care in the current treatment paradigm, which includes neoadjuvant chemotherapy (NAC), affect survival. METHODS: Subjects with American Joint Committee on Cancer stage II urothelial carcinoma of the bladder who underwent RC from 2004 to 2012 were identified from the linked Surveillance, Epidemiology, and End Results national cancer registry and the Medicare claims database and were stratified into RC groups with or without NAC. Cox multivariable proportional hazard models and multivariable logistic regression models assessed the significance of delays in RC for survival and identified independent characteristics associated with RC delays, respectively. RESULTS: This study identified 1509 patients with MIBC who underwent RC during the study period. In comparison with timely surgery, delays in RC increased overall mortality, regardless of the use of NAC (hazard ratio [HR] without NAC, 1.34; 95% confidence interval [CI], 1.03-1.76; HR after NAC, 1.63; 95% CI, 1.06-2.52). Patients proceeding to RC without NAC had higher odds of delayed care if they lived in a high-poverty neighborhood (odds ratio [OR], 1.37; 95% CI, 1.01-2.08) or nonmetropolitan area (OR, 1.61; 95% CI, 1.01-2.55), were men (OR, 2.22; 95% CI, 1.25-4.00), or required a provider transfer for bladder cancer care (OR, 1.82; 95% CI, 1.10-3.03). CONCLUSIONS: Delays in care from the time of either the initial diagnosis or the completion of NAC to RC are associated with worse overall survival among patients with MIBC. Timely surgery is fundamental in the treatment of MIBC, and this necessitates attention to disparities in access to complex surgical care and care coordination.

Firework-related genitourinary trauma: a single institution case series.

PURPOSE: The clinical impact of firework-related genitourinary trauma remains unknown. In this study, we aim to characterize injury patterns, interventions, and clinical outcomes of firework-related genitourinary injuries and evaluate the relationship with certain firework types. METHODS: A retrospective case series was conducted for patients treated at a level I trauma center from 2005 to 2019 who experienced firework-related genitourinary trauma. Fifteen patients sustained firework-related genitourinary injuries. Injury patterns, operative interventions, clinical outcomes, as well as details of firework type were examined. RESULTS: Firework-related genitourinary injuries were identified in 15 trauma patients. Mean age was 29.7 years (± 14.3, standard deviation), all (100%) patients were male, and most (11; 73.3%) were Caucasian. Average length of stay (LOS) was 10.5 days, and 4 (26.7%) patients required ICU admission. Ten (66.7%) patients underwent 28 operative interventions (mean 1.9 per patient), 7 (46.7%) of whom underwent 15 urologic specific intervention (mean 1.0 per patient). No injury-related deaths occurred. Considering firework type, 10 (66.7%) patients had mortar or shell-related injuries, while 3 (20.0%) involved firecrackers, and 2 (13.3%) involved bottle rockets. All (100%) patients sustained injuries that occurred with the use of legally obtained fireworks and 11 (73.3%) were active users. CONCLUSIONS: Firework-related genitourinary injuries occurred most frequently in young men, lead to polytrauma with the scrotum and penis being the most common urologic sites, had high operative rates, and were most commonly associated with legally obtained fireworks, specifically mortar and shell fireworks. Further investigation is needed to understand the long-term sequelae of these injuries.