[Occupational exposure to asbestos and incidence of malignant mesothelioma in the Lazio region, years 2001-2009: results of the activities of the regional register]. / Esposizione ad amianto e incidenza di mesoteliomi maligni nel Lazio, anni 2001-2009: risultati delle attività del registro regionale.

BACKGROUND: The Lazio Regional Mesothelioma Registry records the incident cases of Malignant Mesothelioma (MM) in residents in the Region since 2001. OBJECTIVES: Estimate the incidence of MM in the Lazio Region (2001-2009) and assess possible asbestos exposures. METHODS: The MM cases, notified by hospitals, regional protection and workplace safety units, Italian Workers' Compensation Authority, other regions, or extracted from hospital information systems and the regional registry of causes of death, are included in the register after analysis of diagnostic procedures (CT scan, chest X-ray, pathology reports and patients' records). Possible asbestos exposure is investigated by standardized interview and thereafter defined by a panel of experts, according to RENAM guidelines. The incidence of MM of the pleura and peritoneum (per 100,000 inhabitants) for the period 2001-2009 is calculated. RESULTS: The incidence of MM among Lazio residents in the period 2001-2009 (600 cases) was estimated to be 1.8 among men and 0.5 among women per 100,000 inhabitants. Information on exposures was collectedfor 54% of the cases (251 men and 78 women); 72% of men (n. 179) and 9% of women (n. 7) had been occupationally exposed to asbestos. The study found that the largest number of cases with occupational exposure was among workers in the construction industry. The number of cases with unknown exposure was very high. CONCLUSIONS: The registry's work revealed the existence of asbestos exposure circumstances that were not sufficiently characterized,for which it is suggested that more detailed industrial hygiene investigations be performed, as well as measurement of asbestos bodies and/or fibres in lung tissue.

[PM 10 exposure and asthma exacerbations in pediatric age: a meta-analysis of panel and time-series studies]. / Esposizione a PM10 e riacutizzazioni dell'asma in età pediatrica: una metanalisi degli studi di panel e di serie temporale.

OBJECTIVE: review of the time series and panel studies on the short term effects of PM10 on the increases of the illness in childhood. DESIGN: meta-analysis of panel and time-series studies. METHODS: all studies cited in PubMed that were published between 1990 and 2003 were selected. The results of individual studies were combined to provide an overall estimate of the effect of PMl0 exposure on hospital admissions or emergency room visits for asthma, the frequency of asthmatic symptoms (wheezing and cough), the use of anti-asthma medications (in addition to regular therapy) and lung functioning (peak expiratory flow PEE 1/min) using fixed effects models. Random effects models were used (ORRE or betaRE, 95% CI) when heterogeneity (p <0.10) was present. The presence of publication bias was tested using Egger's test and the bias was corrected with the "trim and fill" method RESULTS: ten time series studies and 23 panel studies fit the search criteria. Exposure to PM10 was associated with an increase in hospitalizations for asthma (ORRE= 1.017, 95% CI 1.008;1.025), with episodes of wheezing (ORRE= 1.063, 95% CI 1.038;1.087) and coughing (ORRE= 1.026, 95% CI 1.013;1.039), in the use of medications for asthma (ORRE= 1.033, 95% CI 1.008;1.059) and to a decrease in lung function (PRE=-0.269, 95% CI -0.451;-0. 087). We observed heterogeneity and publication bias. The correction for publication bias mitigated the estimates of risk but the most important impact on the results was due to a single, multicenter european study (PEACE) that was very influential CONCLUSION: exposure to PM10 was associated with an increase in hospitalizations for asthma and, in asthmatic children, with the frequency of asthmatic symptoms (wheezing and cough), the use of anti-asthma medications (in addition to regular therapy) and a decrease in lung functioning. Additional research is necessary to explain the causes of the heterogeneity in the estimates.

[Asthma and allergies in childhood in Rome: Italian contribution to the ISAAC II]. / Asma e allergie in età pediatrica a Roma: il contributo italiano a ISAAC II.

A study about the frequency of respiratory and allergic disorders in childhood was carried out in Rome, during the 2000-2001 school year. This survey represents the Italian contribution to the second phase of the International Study on Asthma and Allergies in Childhood (ISAAC Phase Two). A properly filled in ISAAC Phase II questionnaire was returned by parents of 1,760 children attending the fifth grade in primary school (83.5% of the target). Prick tests were performed to provide an objective measure of atopy, defined as skin reactivity to one or more allergens. The presence of visible flexural dermatitis was determined through skin examination. Lifetime prevalence for asthma, allergic rhinitis and eczema was 12.4%, 13.2% and 15.1%, respectively. Period prevalence in the last 12 months was 7.0% for attacks of wheezing or whistling in the chest, 9.1% for rhinitis symptoms, and 9.5% for dermatitis symptoms. A total of 1.6% of the children under examination had a visible flexural dermatitis. Of the children who performed prick test, 31.8% was skin positive at least to one of the adopted allergens. An international comparison with the results of other ISAAC Phase Two studies (conducted in Albania, Germany, Hong Kong, UK and Sweden) has shown that Rome and Hong Kong were the areas with the highest prevalence rate for atopy, but had comparatively low proportions of asthmatic subjects. This inconsistency suggests that factors other than atopy could be responsible for the geographic epidemiological distribution of asthma.

Characteristics of early transient, persistent, and late onset wheezers at 9 to 11 years of age.

STUDY OBJECTIVE: To investigate the early determinants and characteristics of different phenotypes of wheeze in children on the basis of questionnaire data, lung function, and prick tests. DESIGN: Cross-sectional survey. Setting. Rome and Fiumicino municipalities in Lazio region, Italy, within the ISAAC phase II project. SUBJECTS: Sample of 2107 9-11 year old schoolchildren (response rate 83.5%). RESULTS: We divided children into four mutually exclusive groups according to onset of wheeze: 154 early transient (birth to age 2), 51 persistent (birth to age 2 and current), 66 late onset (current only), and 1,446 control subjects (no early or current wheeze). Logistic regression models have shown that a family history of asthma and allergies is strongly associated with persistent and late onset wheezing; exposure to parental smoking--both during pregnancy and during the child's first year of life--is related to persistent wheezing; all children with wheezing show a significantly greater risk to have current respiratory symptoms other than wheeze compared with control subjects; current allergic rhinoconjunctivitis symptoms and atopy are related with both persistent and late onset wheeze. Multiple linear regression models show that forced expiratory rates at 25% to 75% of vital capacity (FEF25-75) and the ratio between forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC) are significantly lower both in early transient (-305 mL/s, -1.7%) and persistent (-298 mL/s, -3.2%) wheezers; FEV1/FVC is significantly reduced in late onset wheezers too (-2.0%). CONCLUSIONS: The strength of the association of family history and exposure to parental smoking varies with the three wheezing phenotypes. Moreover, early, persistent and late onset wheezers have different clinical characteristics in terms of their respiratory health and atopic status.