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1.
6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Bioorg Med Chem Lett
; 94: 129454, 2023 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37591316
2.
Identification of parallel medicinal chemistry protocols to expand branched amine design space.
Org Biomol Chem
; 20(18): 3747-3754, 2022 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35448901
3.
Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes.
Drug Metab Dispos
; 44(8): 1262-9, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27079250
4.
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Angew Chem Int Ed Engl
; 55(33): 9601-5, 2016 08 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27355874
5.
Insights into the novel hydrolytic mechanism of a diethyl 2-phenyl-2-(2-arylacetoxy)methyl malonate ester-based microsomal triglyceride transfer protein (MTP) inhibitor.
Chem Res Toxicol
; 25(10): 2138-52, 2012 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22989032
6.
Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.
Bioorg Med Chem Lett
; 19(9): 2400-3, 2009 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19346127
7.
Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).
ACS Med Chem Lett
; 9(5): 440-445, 2018 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29795756
8.
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(6): 2372-2383, 2018 03 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-29466005
9.
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J Med Chem
; 60(18): 7835-7849, 2017 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28853885
10.
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J Med Chem
; 59(17): 8068-81, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27490827
11.
A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.
J Med Chem
; 48(20): 6326-39, 2005 Oct 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-16190759
12.
Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.
J Med Chem
; 58(21): 8513-28, 2015 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-26509551
13.
A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol.
J Med Chem
; 45(20): 4398-401, 2002 Sep 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-12238919
14.
A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.
J Med Chem
; 46(12): 2283-6, 2003 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12773033
15.
Expedient synthesis of α-(2-azaheteroaryl) acetates via the addition of silyl ketene acetals to azine-N-oxides.
Org Lett
; 16(12): 3336-9, 2014 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-24885646
16.
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Structure
; 22(8): 1161-1172, 2014 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25066137
17.
Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-[4-[3R,5S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5]triazin-2-yl]-(R) ethanol.
Bioorg Med Chem
; 11(19): 4179-88, 2003 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12951149
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