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Bioorg Med Chem Lett
; 29(3): 441-448, 2019 02 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30595446
RESUMEN
Exploring various cyclization strategies, using a submicromolar pyrazole HTS screening hit 6 as a starting point, a novel indazole based CCR1 antagonist core was discovered. This report presents the design and SAR of CCR1 indazole and azaindazole antagonists leading to the identification of three development compounds, including 19e that was advanced to early clinical trials.