Detalles de la búsqueda
1.
Intravital Microscopy Reveals Unforeseen Biodistribution Within the Liver and Kidney Mechanistically Connected to the Clearance of a Bifunctional Antibody.
Drug Metab Dispos
; 51(3): 403-412, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36460476
2.
Influence of FcRn binding properties on the gastrointestinal absorption and exposure profile of Fc molecules.
Bioorg Med Chem
; 32: 115942, 2021 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33461147
3.
Modulation of the Biophysical Properties of Bifunctional Antibodies as a Strategy for Mitigating Poor Pharmacokinetics.
Biochemistry
; 58(28): 3116-3132, 2019 07 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-31241304
4.
Mechanisms Influencing the Pharmacokinetics and Disposition of Monoclonal Antibodies and Peptides.
Drug Metab Dispos
; 47(10): 1100-1110, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31043438
5.
Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.
Drug Metab Dispos
; 44(5): 617-23, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26669328
6.
Inhibition of activin A ameliorates skeletal muscle injury and rescues contractile properties by inducing efficient remodeling in female mice.
Am J Pathol
; 184(4): 1152-66, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24655377
7.
Insights into the Impact of Heterogeneous Glycosylation on the Pharmacokinetic Behavior of Follistatin-Fc-Based Biotherapeutics.
Drug Metab Dispos
; 43(12): 1882-90, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26354950
8.
Follistatin: a novel therapeutic for the improvement of muscle regeneration.
J Pharmacol Exp Ther
; 349(2): 355-71, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24627466
9.
Generation and activity of a humanized monoclonal antibody that selectively neutralizes the epidermal growth factor receptor ligands transforming growth factor-α and epiregulin.
J Pharmacol Exp Ther
; 349(2): 330-43, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24518034
10.
Application of FcRn binding assays to guide mAb development.
Drug Metab Dispos
; 42(11): 1867-72, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25024401
11.
Reducing target binding affinity improves the therapeutic index of anti-MET antibody-drug conjugate in tumor bearing animals.
PLoS One
; 19(4): e0293703, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38630694
12.
Safety, Tolerability, and Pharmacokinetics of an Oral Small Molecule Inhibitor of IL-17A (LY3509754): A Phase I Randomized Placebo-Controlled Study.
Clin Pharmacol Ther
; 115(5): 1152-1161, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38294091
13.
Advancing the utilization of real-world data and real-world evidence in clinical pharmacology and translational research-Proceedings from the ASCPT 2023 preconference workshop.
Clin Transl Sci
; 17(4): e13785, 2024 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38572980
14.
An engineered human follistatin variant: insights into the pharmacokinetic and pharmocodynamic relationships of a novel molecule with broad therapeutic potential.
J Pharmacol Exp Ther
; 344(3): 616-23, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23249626
15.
Clinical Pharmacology Applications of Real-World Data and Real-World Evidence in Drug Development and Approval-An Industry Perspective.
Clin Pharmacol Ther
; 114(4): 751-767, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37393555
16.
FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys.
Drug Metab Dispos
; 40(8): 1545-55, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22584253
17.
Monoclonal Antibody Pharmacokinetics in Cynomolgus Monkeys Following Subcutaneous Administration: Physiologically Based Model Predictions from Physiochemical Properties.
AAPS J
; 25(1): 5, 2022 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36456779
18.
Physiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties.
MAbs
; 14(1): 2056944, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35491902
19.
Pharmacokinetic Developability and Disposition Profiles of Bispecific Antibodies: A Case Study with Two Molecules.
Antibodies (Basel)
; 11(1)2021 Dec 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35076469
20.
Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies.
MAbs
; 12(1): 1770028, 2020 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32486889