Estimating air temperature using MODIS surface temperature images for assessing Aedes aegypti thermal niche in Bangkok, Thailand.

Dengue, the most widespread urban vector-borne disease, is transmitted to human by the mosquito Aedes aegypti. Its distribution in urban areas is heterogeneous over time and space. In time, it is linked to seasonal variations such as warm and cold seasons, as well as rainy and dry seasons. In space, it is linked to social and environmental conditions, which alternate between rich and deprived neighborhoods, vegetated and densely built areas. These variations in terms of land cover can affect surface and air temperature. As a result of its influence on the mosquito's life cycle, temperature plays a crucial part in dengue epidemics potential. Thus, deciphering the thermal variations effects within cities could lead to the identification of precise thermal comfort zones, favorable to the survival of mosquito populations during inter-epidemic periods. The maps that could be produced as a result would enable health authorities to target specific areas. Most cities are equipped with meteorological stations. However, the network is generally not dense enough to precisely identify thermal comfort zones. Remote sensing can be used as a tool to solve this issue. The methodological objective of this paper is to assess the potential of the TVX (Temperature-Vegetation indeX) approach applied to MODIS thermal images for the purpose of estimating daily minimum and maximum air temperatures in the city of Bangkok, Thailand. The TVX approach has been seldom used over urban areas due to the heterogeneous nature of cities in terms of land cover. However, our study shows that in vegetated cities such as Bangkok, the TVX method provides valuable results which can be used to assess thermal niche of A. aegypti.

Dealing with mixed and non-normative traffic. An agent-based simulation with the GAMA platform.

Continuous improvement in computing power allowed for an increase of the scales micro-traffic models can be used at. Among them, agent-based frameworks are now appropriate for studying ordinary traffic conditions at city-scale, but remain difficult to adapt, especially for non-computer scientists, to more specific application contexts (e.g., car accidents, evacuation following a natural disaster), that require integrating particular behaviors for the agents. In this paper, we present a built-in model integrated into the GAMA open-source modeling and simulation platform, allowing the modeler to easily define traffic simulations with a detailed representation of the driver's operational behaviors. In particular, it allows modelling road infrastructures and traffic signals, change of lanes by driver agents and less normative traffic mixing car and motorbike as in some South East Asian countries. Moreover, the model allows to carry out city-level simulations with tens of thousands of driver agents. An experiment carried out shows that the model can accurately reproduce the traffic in Hanoi, Vietnam.

Importance of Public Transport Networks for Reconciling the Spatial Distribution of Dengue and the Association of Socio-Economic Factors with Dengue Risk in Bangkok, Thailand.

Dengue is the most widespread mosquito-borne viral disease of man and spreading at an alarming rate. Socio-economic inequality has long been thought to contribute to providing an environment for viral propagation. However, identifying socio-economic (SE) risk factors is confounded by intra-urban daily human mobility, with virus being ferried across cities. This study aimed to identify SE variables associated with dengue at a subdistrict level in Bangkok, analyse how they explain observed dengue hotspots and assess the impact of mobility networks on such associations. Using meteorological, dengue case, national statistics, and transport databases from the Bangkok authorities, we applied statistical association and spatial analyses to identify SE variables associated with dengue and spatial hotspots and the extent to which incorporating transport data impacts the observed associations. We identified three SE risk factors at the subdistrict level: lack of education, % of houses being cement/brick, and number of houses as being associated with increased risk of dengue. Spatial hotspots of dengue were found to occur consistently in the centre of the city, but which did not entirely have the socio-economic risk factor characteristics. Incorporation of the intra-urban transport network, however, much improved the overall statistical association of the socio-economic variables with dengue incidence and reconciled the incongruous difference between the spatial hotspots and the SE risk factors. Our study suggests that incorporating transport networks enables a more real-world analysis within urban areas and should enable improvements in the identification of risk factors.

Widespread fear of dengue transmission but poor practices of dengue prevention: A study in the slums of Delhi, India.

BACKGROUND: This study has been conducted to throw light on the knowledge and practices related to dengue fever among the poor population living in Delhi's slums. MATERIALS: A household survey was conducted in 2013 among 3,350 households. The households were stratified by a number of variables related to socio-economic status and health events such as hospitalisation. The data collection was completed through face-to-face interviews conducted with the help of 25 field investigators. RESULTS: About 8% of the households had at least one diagnosed dengue case. In comparison to the population surveyed, teenagers (15-19 years) and adults (30-34 years) were more affected whereas children under four years of age were underrepresented. Housewives are more affected by dengue (24%) compared to their share of the population surveyed (17%). Despite the fact that 77% of the respondents are worried about mosquitoes, only 43% of them monitor environment to avoid the presence of breeding sites. CONCLUSION: One cannot exclude the possibility that though young children under the age of four years are exposed to the virus, either their cases were asymptomatic or family members infected during this period had potentially more serious symptoms leading to hospitalisation. This result could thus be explained by budget-related health choices made by this population which do not favour small children. Educational programs should target housewives to improve their impact, as they are the ones mostly responsible for water storage and cleanliness of the house and its neighbourhood. Even with a dengue experience and potentially an acute perception of the risk and its factors, a proper management of environmental conditions is lacking. This along with the fact that word-of-mouth is the main source of information quoted should be a message for municipality health workers to give door-to-door information on how to prevent breeding sites and dengue infection.

Urban climate versus global climate change-what makes the difference for dengue?

The expansion in the geographical distribution of vector-borne diseases is a much emphasized consequence of climate change, as are the consequences of urbanization for diseases that are already endemic, which may be even more important for public health. In this paper, we focus on dengue, the most widespread urban vector-borne disease. Largely urban with a tropical/subtropical distribution and vectored by a domesticated mosquito, Aedes aegypti, dengue poses a serious public health threat. Temperature plays a determinant role in dengue epidemic potential, affecting crucial parts of the mosquito and viral life cycles. The urban predilection of the mosquito species will further exacerbate the impact of global temperature change because of the urban heat island effect. Even within a city, temperatures can vary by 10 °C according to urban land use, and diurnal temperature range (DTR) can be even greater. DTR has been shown to contribute significantly to dengue epidemic potential. Unraveling the importance of within-city temperature is as important for dengue as for the negative health consequences of high temperatures that have thus far been emphasized, for example, pollution and heat stroke. Urban and landscape planning designed to mitigate the non-infectious negative effects of temperature should additionally focus on dengue, which is currently spreading worldwide with no signs of respite.

The Spread of Dengue in an Endemic Urban Milieu--The Case of Delhi, India.

BACKGROUND: Dengue is a major international public health concern, one of the most important arthropod-borne diseases. More than 3.5 billion people are at risk of dengue infection and there are an estimated 390 million dengue infections annually. This prolific increase has been connected to societal changes such as population growth and increasing urbanization generating intense agglomeration leading to proliferation of synanthropic mosquito species. Quantifying the spatio-temporal epidemiology of dengue in large cities within the context of a Geographic Information System is a first step in the identification of socio-economic risk factors. METHODOLOGY/PRINCIPAL FINDINGS: This Project has been approved by the ethical committee of Institut Pasteur. Data has been anonymized and de-identified prior to geolocalisation and analysis. A GIS was developed for Delhi, enabling typological characterization of the urban environment. Dengue cases identified in the Delhi surveillance system from 2008 to 2010 were collated, localised and embedded within this GIS. The spatio-temporal distribution of dengue cases and extent of clustering were analyzed. Increasing distance from the forest in Delhi reduced the risk of occurrence of a dengue case. Proximity to a hospital did not increase risk of a notified dengue case. Overall, there was high heterogeneity in incidence rate within areas with the same socio-economical profiles and substantial inter-annual variability. Dengue affected the poorest areas with high density of humans, but rich areas were also found to be infected, potentially because of their central location with respect to the daily mobility network of Delhi. Dengue cases were highly clustered in space and there was a strong relationship between the time of introduction of the virus and subsequent cluster size. At a larger scale, earlier introduction predicted the total number of cases. CONCLUSIONS/SIGNIFICANCE: DENV epidemiology within Delhi has a forest fire signature. The stochastic nature of this invasion process likely smothers any detectable socio-economic risk factors. However, the significant finding that the size of the dengue case cluster depends on the timing of its emergence emphasizes the need for early case detection and implementation of effective mosquito control. A better understanding of the role of population mobility in contributing to dengue risk could also help focus control on areas at particular risk of dengue virus importation.