Gender differences in suicide methods.

INTRODUCTION: Gender differences in suicide completion rates have been attributed to the differences in lethality of suicide methods chosen by men and women, but few empirical studies have investigated factors other than demographic characteristics that might explain this differential. METHODS: Data from the 621 suicides in Summit County, Ohio during 1997-2006 were disaggregated by gender to compare known correlates of suicide risk on three methods of suicide-firearm, hanging and drug poisoning. RESULTS: Compared to women, men who completed suicide with firearms were more likely to be married and committed the act at home. Unmarried men were likelier to hang themselves than married men, but unmarried women were less likely to hang themselves than married women. Men with a history of depression were more likely to suicide by hanging, but women with depression were half as likely to hang themselves compared to the women without a history of depression. Men with a history of substance abuse were more likely to suicide by poisoning than men without such history, but substance abuse history had no influence on women's use of poisoning to suicide. For both sexes, the odds of suicide by poisoning were significantly higher for those on psychiatric medications.

In vitro-in vivo correlation for nevirapine extended release tablets.

An in vitro-in vivo correlation (IVIVC) for four nevirapine extended release tablets with varying polymer contents was developed. The pharmacokinetics of extended release formulations were assessed in a parallel group study with healthy volunteers and compared with corresponding in vitro dissolution data obtained using a USP apparatus type 1. In vitro samples were analysed using HPLC with UV detection and in vivo samples were analysed using a HPLC-MS/MS assay; the IVIVC analyses comparing the two results were performed using WinNonlin. A Double Weibull model optimally fits the in vitro data. A unit impulse response (UIR) was assessed using the fastest ER formulation as a reference. The deconvolution of the in vivo concentration time data was performed using the UIR to estimate an in vivo drug release profile. A linear model with a time-scaling factor clarified the relationship between in vitro and in vivo data. The predictability of the final model was consistent based on internal validation. Average percent prediction errors for pharmacokinetic parameters were <10% and individual values for all formulations were <15%. Therefore, a Level A IVIVC was developed and validated for nevirapine extended release formulations providing robust predictions of in vivo profiles based on in vitro dissolution profiles.

Responsible Conduct of Research Measure: initial development and pilot study.

Although much discussion has been focused on research misconduct (RM) and questionable research practices, to date no self-report measures exist to examine this phenomenon. To help fill this void, the authors developed the Responsible Conduct of Research Measure (RCRM) through multiple pilot study waves involving researchers in the social and behavioral sciences. Preliminary results reveal adequate validity and reliability. The authors discuss limitations of the study as well as some possible directions for future research on this topic.

The role of culture in research misconduct.

There seems to be a taboo against discussing the role culture or national origin might play in research misconduct. Still, some observers wonder why so many scientists representing foreign cultures are among those found guilty of misconduct. Even after examining the scant available data, whether foreign nationals are disproportionately represented among Office of Research Integrity (ORI) respondents remains unclear. The lack of data, however, does not negate culture as a possible explanatory variable in research misconduct. Applying theories from sociological criminology, the author posits that the culture some researchers bring may be at odds with the norms of academic science and may emphasize ends more than means. As such, culture simply may be one of several etiological factors in research misconduct and should be considered in the spirit of objective scientific inquiry. Acknowledging the role of culture in the adherence to research ethics underscores the importance of education and training of both researchers and administrators in the responsible conduct of research and cultural diversity.

A new measure of interpersonal exploitativeness.

Measures of exploitativeness evidence problems with validity and reliability. The present set of studies assessed a new measure [the Interpersonal Exploitativeness Scale (IES)] that defines exploitativeness in terms of reciprocity. In Studies 1 and 2, 33 items were administered to participants. Exploratory and Confirmatory Factor Analysis demonstrated that a single factor consisting of six items adequately assess interpersonal exploitativeness. Study 3 results revealed that the IES was positively associated with "normal" narcissism, pathological narcissism, psychological entitlement, and negative reciprocity and negatively correlated with positive reciprocity. In Study 4, participants competed in a commons dilemma. Those who scored higher on the IES were more likely to harvest a greater share of resources over time, even while controlling for other relevant variables, such as entitlement. Together, these studies show the IES to be a valid and reliable measure of interpersonal exploitativeness. The authors discuss the implications of these studies.

Assessing legal strains and risk of suicide using archived court data.

Relatively little is known about legal entanglements and suicide risk. This matched case-control study estimated the risk of suicide associated with legal strains using online court archives, a novel source of exposure data. Court records linked to suicide deaths (N = 315), controls (N = 630), and unintentional injury and poisoning deaths (N = 630) for an urban county from 2000 to 2005 revealed that nearly a third of suicide victims had recent court involvement, twice the proportion among controls. Misdemeanors, car accidents, and foreclosures were each associated with a threefold risk of suicide. Implications for suicide prevention and research are discussed.

A comparison of suicide note writers with suicides who did not leave notes.

There is disagreement in the suicide literature on the value of suicide notes as a data source, particularly regarding the extent to which suicide decedents who write notes differ from those who do not. Using 10 years of suicide cases from Summit County, Ohio, these two groups were compared on 40 variables including sociodemographic characteristics, reported affect before death, precipitating events, physical and mental health status and care, and method of suicide. The only differences found were that note writers were more likely to have lived alone and had made prior suicide threats. These findings suggest that for research purposes, suicide cases with and without notes are essentially similar.

An inquiry into relationship suicides and reciprocity.

Few theories on suicide have been grounded in the norm of reciprocity. There is literature on suicide, however, describing motivations such as retaliation and retreat which can be interpreted as modes of adaptation to the norm of reciprocity. We propose a reciprocity-based theory to explain suicides associated with relationship problems. Employing a content analysis of suicide notes, we tested the theory, finding evidence of exploitation, exploiter guilt, retaliation, and retreat as motives for committing relationship-based suicide. Reciprocity-based note writers were more likely to have used alcohol or drugs in the hours prior to committing suicide, and they were also more likely to have made their intentions known beforehand. Implications for future research as well as for suicide prevention are discussed.

Causal factors implicated in research misconduct: evidence from ORI case files.

There has been relatively little empirical research into the causes of research misconduct. To begin to address this void, the authors collected data from closed case files of the Office of Research Integrity (ORI). These data were in the form of statements extracted from ORI file documents including transcripts, investigative reports, witness statements, and correspondence. Researchers assigned these statements to 44 different concepts. These concepts were then analyzed using multidimensional scaling and cluster analysis. The authors chose a solution consisting of seven clusters: (1) personal and professional stressors, (2) organizational climate, (3) job insecurities, (4) rationalizations A, (5) personal inhibitions, (6) rationalizations B and, (7) personality factors. The authors discuss the implications of their findings for policy and for future research.

VARIATION IN THE CODING OF SPECIES IDENTITY IN THE ADVERTISEMENT CALLS OF LITORIA VERREAUXI (ANURA: HYLIDAE).

Variation within and among males was documented in two properties of the advertisement call of Litoria verreauxi; comparisons were also made between populations of L. verreauxi that were allopatric and sympatric with L. ewingi. Pulse rate, a property of known importance in mate recognition, was stereotyped. However, a character upon which the full expression of pulse rate depends, the depth of amplitude modulation (AM) or pulsing, was significantly lower and more variable in populations of L. verreauxi that coexisted with L. ewingi than in allopatric populations of L. verreauxi. Furthermore, there were significant changes in the depth of AM in the calls of sympatric males recorded from one night to another within the breeding season. The within-male variation (between recordings) in this character within sympatric populations was so great that statistically significant differences between males could not be detected. Thus, even if gravid females in sympatry choose a male on the basis of the degree to which his calls are pulsed, the evolutionary response to such selection would probably be very limited. The change that appears to be occurring in the temporal code for species identity vis-à-vis L. ewingi in sympatry (a change from a quantitative difference [pulse rate] to a qualitative one [pulsed versus unpulsed calls]) is probably a passive consequence of the shift to higher pulse rates.