Leishmania amastigotes in neoplastic cells of 3 nonhistiocytic canine tumors.

Concurrent leishmaniasis and neoplasia has been reported in dogs. This study describes the presence of the protozoa within the cytoplasm of neoplastic cells in 3 different types of tumors. Leishmania amastigotes were detected by light and transmission electron microscopy and immunohistochemistry in a fibrosarcoma, a T-cell lymphoma, and an adrenocortical adenoma.

[Statistics on 123 children with febrile convulsions from 1976 to 1981 with possible advantages of continuous prophylaxis with valproic acid and/or phenobarbital]. / Rilievi statistici condotti dal 1976 al 1981 sulle convulsioni febbrili in 123 bambini e sui possibili vantaggi della profilassi continua con dipropilacetato e/o fenobarbital.

All children (6 months to 5 years of age) presenting with febrile seizures have been followed for 3-5 years. Analysis of the data of 123 children gave the following results: -in 20 cases the duration of the convulsions was longer than 20 minutes; -males were prevalent (60,2%) and characterised by a longer duration of convulsive manifestations (20,2% of cases); -valproic acid (20-30 mg/kg/die) or phenobarbital (3-5 mg/kg/die) prophylaxis for a minimum of I year protect against recurrence of convulsions (26,6% of new episodes in non treated vs 10,2% in treated patients); -irrespective of drug prophylaxis, recurrence is minimal and approaches zero, when the first episode occurs in children older than 3 years; -only one case (0,8%) had recurrence not associated with fever, during valproic acid treatment two years after the first episode.