1.
J Org Chem
; 86(18): 12693-12704, 2021 Sep 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34491765
RESUMEN
We report herein the facile and practical construction of α,ß-unsaturated ketones via rhodium-catalyzed direct acylation of vinylsilanes with readily available and abundant carboxylic acids. This protocol features access to a diverse array of synthetically useful functionalities with moderate to excellent yields. More importantly, the late-stage functionalization of pharmaceuticals was also realized with synthetically useful yield.