1.
Bioorg Med Chem Lett
; 19(16): 4555-9, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19625189
RESUMEN
Synthesis and structure-activity relationship (SAR) studies on 5-trifluoromethylpyrido[4,3-d]pyrimidin-4(3H)-ones, a novel class of calcium receptor antagonists is described with particular emphasis on optimization of the pharmacokinetic/pharmacodynamic parameters required for a short duration of action compound. Orally-active compounds were identified which displayed the desired animal pharmacology (rapid and transient stimulation of parathyroid hormone) essential for bone anabolic effects.