1.
Bioorg Med Chem
; 23(11): 2716-20, 2015 Jun 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25680845
RESUMEN
The introduction of silicon in biologically-relevant molecules represents an interesting medicinal chemistry tactic. Its use is mainly confined to the fine-tuning of specific molecular properties and organosilicon compounds are underrepresented in typical screening libraries. As part of the European Lead Factory efforts to generate novel, drug discovery-relevant chemical matter, the design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries is described.