1.
Nat Methods
; 7(6): 447-9, 2010 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20453868
RESUMEN
Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically assessed. We developed the mouse grimace scale (MGS), a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain. This measure of spontaneously emitted pain may provide insight into the subjective pain experience of mice.