Detalles de la búsqueda
1.
Design, synthesis, and biological evaluation of novel molecules as potent inhibitors of PLK1.
Bioorg Chem
; 139: 106711, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37473479
2.
PCC0208023, a potent SHP2 allosteric inhibitor, imparts an antitumor effect against KRAS mutant colorectal cancer.
Toxicol Appl Pharmacol
; 398: 115019, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32335126
3.
Pharmacokinetics of S-EPA, and its inhibition on indoleamine 2,3-dioxgenase: a case of sulfur-substitution affecting distributions in blood cells.
Xenobiotica
; 49(11): 1338-1343, 2019 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30507339
4.
NSK-01105 inhibits proliferation and induces apoptosis of prostate cancer cells by blocking the Raf/MEK/ERK and PI3K/Akt/mTOR signal pathways.
Tumour Biol
; 36(3): 2143-53, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25398692
5.
Use of Microscopic Characteristics and Multielemental Fingerprinting Analysis to Trace Three Different Cultivation Modes of Medicinal and Edible Dendrobium officinale in China.
Biol Trace Elem Res
; 201(2): 1006-1018, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-35507137
6.
Non-clinical pharmacology and toxicology studies of LPM6690061, a novel 5-hydroxytryptamine (5-HT)2A receptor inverse agonist.
Food Chem Toxicol
; 176: 113800, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-37100235
7.
Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5.
Cell Discov
; 9(1): 3, 2023 Jan 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36609558
8.
9-Cyclopropylmethoxy-dihydrotetrabenazine and its stereoisomers as vesicular monoamine transporter-2 inhibitors.
Future Med Chem
; 14(13): 991-1003, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35638444
9.
Improving the treatment of Parkinson's disease: Structure-based development of novel 5-HT2A receptor antagonists/inverse agonists.
Eur J Med Chem
; 234: 114246, 2022 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35279606
10.
(+)-9-Trifluoroethoxy-α-Dihydrotetrabenazine as a Highly Potent Vesicular Monoamine Transporter 2 Inhibitor for Tardive Dyskinesia.
Front Pharmacol
; 12: 770377, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34950030
11.
Synthesis and analysis of dihydrotetrabenazine derivatives as novel vesicular monoamine transporter 2 inhibitors.
Eur J Med Chem
; 224: 113718, 2021 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34329999
12.
Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2.
Commun Biol
; 4(1): 500, 2021 04 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-33893388
13.
Comparison study of different indoleamine-2,3 dioxygenase inhibitors from the perspective of pharmacodynamic effects.
Int J Immunopathol Pharmacol
; 34: 2058738420950584, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32962460
14.
PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice.
PLoS One
; 15(3): e0228339, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32214351
15.
PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala.
Biochem Pharmacol
; 177: 113926, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32217098
16.
PCC0208018 exerts antitumor effects by activating effector T cells.
Int J Immunopathol Pharmacol
; 33: 2058738419843366, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30968715
17.
PCC0208009 enhances the anti-tumor effects of temozolomide through direct inhibition and transcriptional regulation of indoleamine 2,3-dioxygenase in glioma models.
Int J Immunopathol Pharmacol
; 32: 2058738418787991, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29993291
18.
Determination of kynurnine and tryptophan, biomarkers of indoleamine 2,3-dioxygenase by LC-MS/MS in plasma and tumor.
Bioanalysis
; 10(16): 1335-1344, 2018 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30130131
19.
Combinatorial antitumor effects of indoleamine 2,3-dioxygenase inhibitor NLG919 and paclitaxel in a murine B16-F10 melanoma model.
Int J Immunopathol Pharmacol
; 30(3): 215-226, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28604143
20.
NSK-01105, a novel sorafenib derivative, inhibits human prostate tumor growth via suppression of VEGFR2/EGFR-mediated angiogenesis.
PLoS One
; 9(12): e115041, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25551444