RESUMEN
C-H activation has emerged as a powerful transformative synthetic tool to construct complex molecular frameworks, which are ubiquitous in natural products, medicines, dyes, polymers, and many more. However, reactivity and selectivity, arising from the inertness of C-H bonds and their overabundance in organic molecules, are the two major fundamental challenges in developing various carbon-carbon (C-C) and carbon-heteroatom (C-X) bond formation reactions via C-H activation technique. Functional groups with coordinating capacity to the transition metal catalysts, profoundly known as directing groups (DGs), have shown great promise in exerting selective C-H activation, often called site-selective or regioselective transformation of a target molecule. Advent of directing group (DG)-assisted strategies not only has resolved the selectivity issues but also offers a unique solution to the rapid synthesis of complex molecules in a convenient and predictable manner. Our laboratory, in this regard, is fascinated by the prospect of DG-assisted distal C-H functionalization of arenes, in which the target C-H bond is remotely located from the existing directing group. Notably, in opposition to proximal ortho-C-H activation, which proceeded via an energetically favorable five- to seven-membered metallacycle, distal C-H activation remained a formidable challenge as it required formation of a large macrocyclic metallacycle. Therefore, designing a suitable directing template that would maintain the required distance and geometric relationship between the target C-H bond and the appended directing auxiliary in order to ensure the prolific delivery of the metal catalyst to the closest proximity of targeted distal C-H bond was the key to success. In this regard, the Yu group devised an elegant "U-shaped" template for the first time to execute distal meta-C-H activation recruiting a cyano-based directing group. Our initial effort to diversify the scope of meta-C-H functionalization using a cyano-based template led us to realize that the "cyano-based DGs" are intrinsically limited with weak coordinating ability, competitive binding mode (end-on vs side-on), and incompatibility with acidic and basic reaction conditions. In search of a robust directing auxiliary, we were intrigued by the possibility of using the strongly coordinating ability of pyrimidine and quinoline-based DGs.In this Account, we describe our journey from the weakly coordinating cyano-based DG to the strongly coordinating pyrimidine-based DG to achieve diverse meta-C-H functionalization of electronically and sterically unbiased arenes. While some of the functionalizations were achieved by finding suitable reaction conditions, others were led by mechanistic understanding. Notably, initial development in this realm was constrained with short linkers, in which the DG was attached to the arene of interest through 2-4 atoms. In later studies, we demonstrated that the selective meta-C-H activation can be attained even though the DG is 10-atoms away from the targeted arene. More importantly, a transient DG was successfully utilized to deliver meta-C-H olefination of arenes via in situ imine formation, which provided a step-economic route to meta-C-H activation.We hope that this Account will stimulate further template design and will provide a guiding platform for the future development of distal meta-C-H functionalization.
Asunto(s)
Elementos de Transición , Carbono/química , Catálisis , Metales , PirimidinasRESUMEN
Controlling remote selectivity and delivering novel functionalities at distal positions in arenes are an important endeavor in contemporary organic synthesis. In this vein, template engineering and mechanistic understanding of new functionalization strategies are essential for enhancing the scope of such methods. Herein, meta-C-H allylation of arenes has been achieved with the aid of a palladium catalyst, pyrimidine-based auxiliary, and allyl phosphate. 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) was found as a critical solvent in this transformation. The role of HFIP throughout the catalytic cycle has been systematically studied. A broad substrate scope with phenethyl ether, phenol, benzylsulfonyl ester, phenethylsulfonyl ester, phenylacetic acid, hydrocinnamic acid, and 2-phenylbenzoic acid derivatives has been demonstrated. Interestingly, conformationally flexible arenes have also been selectively allylated at the meta-position using allyl phosphate. A combination of 1H NMR, 31P NMR, ESI-MS, kinetic experiments, and density functional theory (DFT) computations suggested that reaction proceeds through a ligand-assisted meta-C-H activation, allyl addition forming a Pd-π-allyl complex which is then followed by a turnover determining the C-C bond formation step leading to the meta-allylated product.
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The significance of site selective functionalization stands upon the superior selectivity, easy synthesis and diverse product utility. In this work, we demonstrate the para-selective introduction of versatile nitrile moiety, enabled by a detachable and reusable H-bonded auxiliary. The methodology holds its efficiency irrespective of substrate electronic bias. The conspicuous shift in the step energetics was probed by both experimental and computational mechanistic tools, which heralds the inception of para-deuteration. The synthetic impact of the methodology was highlighted with reusability of directing group and post synthetic modifications.
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Biaryl compounds are extremely important structural motifs in natural products, biologically active components and pharmaceuticals. Selective synthesis of biaryls by distinguishing the subtle reactivity difference of distal arene C-H bonds are significantly challenging. Herein, we describe para-selective C-H arylation, which is acheived by a unique combination of a meta-directing group and norbornene as a transient mediator. Upon direct meta-C-H palladation, one-bond relay palladation occurs in presence of norbornene and subsequently para-C-H arylation is achieved for sulfonates, phosphonates and phenols bearing 2,6-disubstitution patterns. The protocol is amenable to electron-deficient aryl iodides. Multisubstituted arenes and phenols are obtained by postsynthetic modification of the products. The protocol allows the synthesis of hexa-substituted benzene by sequential selective distal C-H functionalization.
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An easily removable pyrimidine-based auxiliary has been employed for the remote meta-C-H cyanation of arenes. The scope of this Pd-catalyzed cyanation reaction using copper(I) cyanide as the cyanating agent was demonstrated with benzylsilanes, benzylsulfonates, benzylphophonates, phenethylsulfonates, and phenethyl ether derivatives. The method was utilized for the synthesis of pharmaceutically valuable precursors.
RESUMEN
Site-selective C-H functionalization has emerged as an efficient tool in simplifying the synthesis of complex molecules. Most often, directing group (DG)-assisted metallacycle formation serves as an efficient strategy to ensure promising regioselectivity. A wide variety of ortho- and meta-C-H functionalizations stand as examples in this regard. Yet despite this significant progress, DG-assisted selective para-C-H functionalization in arenes has remained unexplored, mainly because it involves the formation of a geometrically constrained metallacyclic transition state. Here we report an easily recyclable, novel Si-containing biphenyl-based template that directs efficient functionalization of the distal p-C-H bond of toluene by forming a D-shaped assembly. This DG allows the required flexibility to support the formation of an oversized pre-transition state. By overcoming electronic and steric bias, para-olefination and acetoxylation were successfully performed while undermining o- and m-C-H activation. The applicability of this D-shaped biphenyl template-based strategy is demonstrated by synthesizing various complex molecules.
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Regioselective C-H alkynylation of arenes via C-H activation is challenging yet a highly desirable transformation. In this regard, directing group assisted C(sp2)-H alkynylation of arenes offers a unique opportunity to ensure precise regioselectivity. While the existing methods are mainly centered around ortho-C-H alkynylation and a few for meta-C-H alkynylation, the DG-assisted para-selective C-H alkynylation is yet to be reported. Herein we disclose the first report on Rh-catalyzed para-C-H alkynylation of sterically and electronically unbiased arenes. The para-selectivity is achieved with the assistance of a cyano-based directing template and the selectivity remained unaltered irrespective of the steric and electronic influence of the substituents. The post-synthetic modification of synthesized para-alkynylated arenes is also demonstrated. The mechanistic intricacies of the developed protocol are elucidated through experimental and computational studies.
RESUMEN
Site-selective C-H alkynylation of arenes to produce aryl alkynes is a highly desirable transformation due to the prevalence of aryl alkynes in various natural products, drug molecules and in materials. To ensure site-selective C-H functionalization, directing group (DG) assisted C-H activation has been evolved as a useful synthetic tool. In contrast to DG-assisted ortho-C-H activation, distal meta-C-H activation is highly challenging and has attracted significant attention in recent years. However, developments are majorly focused on Pd-based catalytic systems. In order to diversify the scope of distal meta-C-H functionalization, herein we disclosed the first Rh(i) catalyzed meta-C-H alkynylation protocol through the inverse Sonogashira coupling reaction. The protocol is compatible with various substrate classes which include phenylacetic acids, hydrocinnamic acids, 2-phenyl benzoic acids, 2-phenyl phenols, benzyl sulfonates and ether-based scaffolds. The post-synthetic modification of meta-alkynylated arenes is also demonstrated through DG-removal as well as functional group interconversion.
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Transition metal-catalyzed aryl C-H activation is a powerful synthetic tool as it offers step and atom-economical routes to site-selective functionalization. Compared with proximal ortho-C-H activation, distal (meta- and/or para-) C-H activation remains more challenging due to the inaccessibility of these sites in the formation of energetically favorable organometallic pretransition states. Directing the catalyst toward the distal C-H bonds requires judicious template engineering and catalyst design, as well as prudent choice of ligands. This review aims to summarize the recent elegant discoveries exploiting directing group assistance, transient mediators or traceless directors, noncovalent interactions, and catalyst and/or ligand selection to control distal C-H activation.
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Rhodium catalysis has been extensively used for ortho-C-H functionalization reactions, and successfully extended to meta-C-H functionalization. Its application to para-C-H activation remains an unmet challenge. Herein we disclose the first example of such a reaction, with the Rh-catalyzed para-C-H olefination of arenes. The use of a Si-linked cyanobiphenyl unit as a traceless directing group leads to highly para-selective arene-olefin couplings.
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The effects of spermatheca gland extract of snail (Telescopium telescopium) to promote wound healing were studied in an animal model. The spermatheca gland extract of the snail was used as a topical medicament to treat experimentally created full thickness wounds in 12 rabbits (Oryctologous cuniculus). Wound healing was assessed on the basis of physical, histomorphological, and histochemical changes on days 0, 3, 7, and 14. Statistically significant differences were observed between the groups in all measured parameters. These exciting findings suggest that the data should be further tested in animal models to better understand the potential for wound healing in the spermatheca gland extract of the marine snail.
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Caracoles , Extractos de Tejidos/uso terapéutico , Cicatrización de Heridas , Heridas y Lesiones/terapia , Animales , Lectinas , Conejos , Distribución AleatoriaRESUMEN
The (5 + 1) annulation of ynone/cinnamates and related substrates with protected primary amines gives rise to isoquinolones, pyrrolidinones and pyrrolopiperazines in good to excellent yields under phosphine catalysis. The reaction is viable with chiral phosphines, although the selectivity is poor.
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Alkyne C≡C bond breaking, outside of alkyne metathesis, remains an underdeveloped area in reaction discovery. Recently, nitrogenation has been reported to allow nitrile formation from alkynes. A new protocol for the metal-free C≡C bond cleavage of terminal alkynes to produce nitriles is reported. This method provides an opportunity to synthesize a vast range of nitriles containing aryl, heteroaryl, and natural product derivatives (38 examples). In addition, the potential of (t)BuONO to act as a powerful nitrogenating agent for terminal aryl alkynes is demonstrated.
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A radical based direct C-H iodination protocol for quinolines, quinolones, pyridones, pyridines, and uracil has been developed. The iodination occurs in a C3 selective manner for quinolines and quinolones. Pyridones and pyridines undergo C3 and C5 iodination, while dimethyl uracil undergoes C5 iodination. Scope of the method was demonstrated through the rapid synthesis of both electron rich as well as electron poor heteroaromatic iodides. The protocol was found to be scalable and general, while a mechanism has been proposed.
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Yodo/química , Piridonas/síntesis química , Quinolonas/síntesis química , Uracilo/síntesis química , Halogenación , Isomerismo , Modelos Químicos , Piridonas/química , Quinolonas/química , Uracilo/químicaRESUMEN
An efficient method for stereoselective nitroaminoxylation of alkyne has been reported. The reaction enjoys a broad substrate scope, good functional group tolerance, and high yields. Synthetically useful α-nitroketones can be accessed through these products in a single step.
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An intramolecular dehydrogenative (sp(3))C-O bond formation in salicylamides can be initiated by an active Cu/O2 species to generate pharamaceutically relevant dihydro-oxazinones. Experimental findings suggest that stereoelectronic parameters in both coupling partners are controlling factors for site selectivity in bond formation. Mechanistic investigations including isotope labeling, kinetic studies helped to propose a catalytic cycle. The method provides a convenient synthesis of an investigational new medicine CX-614, which has potential in finding treatment for Parkinson's and Alzheimer's diseases.