The cumulative effect of bisphosphonates and statins on stress fractures. Is it a failure of steroid biosynthesis? Case Report.

Osteoporosis related fractures pose a significant economic and healthcare problem. There is a growing concern about increased numbers of stress or low energy fractures after bisphosphonates therapy. A 65-year-old woman is presented with a stress fracture of the left femur. From our point of view, this fracture was associated with a long-term statin and bisphosphonate therapy. We did not find a similar presentation in medical literature.

Acute radial ulno-humeral ligament injury in patients with chronic lateral epicondylitis: an observational report.

PURPOSE: Lateral elbow pain has multiple etiologies; most common is lateral epicondylitis. Radio-capitellar arthritis, posterolateral rotatory instability (PLRI), plica and radial tunnel syndromes may produce similar pain. The purpose of this study is to report on a rare subset of patients who had an acute injury during treatment for chronic lateral epicondylitis, exacerbating symptoms and lessening function. Indications for surgery were a failure of another round of nonoperative management and diagnosis of a new injury to the lateral ligaments in addition to the lateral epicondylitis. Surgical intervention revealed the acute injury to the radial ulno-humeral ligament (RUHL) complex, superimposed on chronic lateral epicondylitis, which we believe caused worsening of symptoms. Surgical repair of both lesions provided satisfactory results. MATERIALS AND METHODS: Seven patients (range, 29-46 years; mean, 40.7) being treated for chronic lateral epicondylitis each sustained an acute elbow injury resulting in PLRI. Study data, including Andrews-Carson Elbow Score (ACES) and Mayo Elbow Performance Score (MEPS), were collected in the initial evaluation and at regular postoperative intervals, with a follow-up period of 12-24 months. Indications for surgery were pain, functional impairment, and failure of other treatments. All surgeries were performed on an outpatient basis under general anesthesia in the prone position. RESULTS: All patients showed arthroscopic evidence of chronic lateral epicondylitis and acute RUHL injury. All showed significant improvement in total ACES and MEPS after repair of both lesions, full range of motion, and objective improvement in strength and function, with no adverse effects or complications. CONCLUSION: Patients with chronic lateral epicondylitis who sustain an acute injury may damage the RUHL complex. Early recognition of this additional injury may allow surgical repair of both injuries with satisfactory results.

Correction of steroidopenia as a new method of hypercholesterolemia treatment.

OBJECTIVE: In 2002 we proposed a new hypothesis of the etiology and pathogenesis of hypercholesterolemia. There is paucity of information in the literature regarding the association of steroidopenia and hypercholesterolemia. Our goal is to determine if the treatment of steroidopenia with hormonorestorative therapy (HT) to youthful levels will normalize total cholesterol (TC) levels. MATERIAL AND METHODS: We retrospectively analyzed 43 hypercholesterolemic patients treated with HT. Laboratory workup included lipid profile, serum pregnenolone, dehydroepiandrosterone sulfate (DHEA-S), progesterone, total estrogen, cortisol, total testosterone, and vitamin D-3 levels at presentation with follow up ranging from 3 to 9 months. HT therapy included a combination of several agents such as pregnenolone, dehydroepiandrosterone (DHEA), triestrogen, progesterone, testosterone, hydrocortisone, and vitamin D-3. RESULTS: HT lowered mean TC from 228.8 mg/dL to 183.7 mg/dL (19.7%) (p<0.05) in all patients. In 12 men of mean age 58, HT statistically significantly lowered TC from 227.9 mg/dL to 177.1 mg/dL (22.3%) (p<0.05). Apparently it did so mostly by lowering LDL and triglycerides (TRG) while HDL did not appreciably change. In 31women, mean age 57, TC declined from 229.2 mg/dL to 186.3 mg/dL (19%) (p<0.05). HDL, LDL, and TRG are also decreased to a statistically significant degree. These results were associated with statistically significant elevations in pregnenolone, DHEA Sulfate, testosterone, progesterone but not total estrogen, cortisol or vitamin D-3 changes in both men and women. CONCLUSIONS: We conclude that correction of steroidopenia with the use of hormonorestorative therapy is an effective strategy for normalizing and maintaining cholesterol homeostasis.

Acetabular fracture patterns and their associated injuries.

OBJECTIVES: Characterize relationships between acetabular fractures patterns and visceral organ injuries. DESIGN: Retrospective review. SETTING: : University medical center. PATIENTS/PARTICIPANTS: Three hundred twenty-three patients with displaced acetabular fractures identified in a prospectively maintained database. INTERVENTION: Acetabular fractures were classified according to force vector at the time of injury. Posterior wall, posterior column, and posterior column/posterior wall injuries were assumed to have been caused by an axial load. The remaining seven acetabular fracture types were assumed to have resulted from a lateral or trochanteric load. Records were reviewed to establish any relationship between acetabular fracture patterns defined by their force vector and injuries to other skeletal and nonskeletal organ systems. MAIN OUTCOME MEASUREMENTS: Comparison of organ injury end points of additional skeletal injury; bowel, bladder, brain, kidney, liver, spleen, and lung injury; retroperitoneal hematoma; and vascular injury of the pelvis. Data were analyzed using chi-square, with statistical significance defined as P < 0.05. RESULTS: Acetabular fractures resulting from lateral loads had a statistically higher association with retroperitoneal hematomas (P < 0.001), spleen (P < 0.008), liver (P < 0.002), vascular (P < 0.001), kidney (P < 0.001), and bladder (P < 0.001) injuries than did posteriorly directed acetabular fractures. Transverse posterior wall fractures exhibited intermediate characteristics between axial load and the remaining lateral load patterns. CONCLUSIONS: Direction of force is important in the etiology of nonskeletal injury patterns. The possibility of additional nonskeletal injury increases from the rates seen in axial load patterns to those in lateral load patterns involving the anterior column.