Minimum-Cost Offloading for Collaborative Task Execution of MEC-Assisted Platooning.

In this paper, we study the offloading decision of collaborative task execution between platoon and Mobile Edge Computing (MEC) server. The mobile application is represented by a series of fine-grained tasks that form a linear topology, each of which is either executed on a local vehicle, offloaded to other members of the platoon, or offloaded to a MEC server. The objective of the design is to minimize the cost of tasks offloading and meets the deadline of tasks execution. The cost minimized task decision problem is transformed into the shortest path problem, which is limited by the deadline of the tasks on a directed acyclic graph. The classical Lagrangian Relaxation-based Aggregated Cost (LARAC) algorithm is adopted to solve the problem approximately. Numerical analysis shows that the scheduling method of the tasks decision can be well applied to the platoon scenario and execute the tasks in cooperation with the MEC server. In addition, compared with task local execution, platoon execution and MEC server execution, the optimal offloading decision for collaborative task execution can significantly reduce the cost of task execution and meet deadlines.

Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice.

Certain glycosphingolipids play important roles as cellular receptor for bacterial toxins with high specificity and strong affinity. In particular AB(5) toxins exhibit typical modes of cell attachment with B5 and invasion and biological effects in cells with A subunit. Subtilase cytotoxin (SubAB) is the prototype of a recently discovered AB(5) cytotoxin family produced by certain strains of Shiga toxigenic Escherichia coli, and shows highly specific serine protease activity toward endoplasmic reticulum chaperone Bip. Since this toxin bound to a mimic of ganglioside GM2, GM2 has been considered to be possible receptor for SubAB. Using six kinds of glycosylation-defective knockout mice lacking certain group of glycosphingolipids, sensitivity to SubAB in vivo was analyzed. Consequently, all mutant mice died at around 70h after intraperitoneal injection of 10 microg (or 7.5 microg) of SubAB as well as wild type mice. These results indicated none of glycolipids are not pivotal receptor for SubAB in the body.