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1.
Health Promot Pract ; 20(2): 223-230, 2019 03.
Artículo en Inglés | MEDLINE | ID: mdl-29557175

RESUMEN

Our global population is aging at an accelerated pace. While the average life expectancy has seen dramatic increases, chronic disease and disability have also increased, with rural America tending to be older, sicker, and poorer. This article examines the implementation and outcomes associated with the community engagement method of the world café that was instrumental in developing a "culture of health" aimed to reduce diabetes-related inequalities for older adults in rural counties of Kentucky. Older residents and the organizations that serve them participated in world cafés, which resulted in collective action due to the wisdom and capacity that evolve from the core element of the method, conversational sharing via multiple small group interactions. Four world cafés were held to explore the desires of the communities related to healthy eating, exercise, smoking cessation, and diabetes care. The world cafés brought a diverse group of community residents and governmental and business leaders to discuss topics that matter to their community, leading to the development of a strategic plan and a scorecard and, ultimately, community empowerment.


Asunto(s)
Diabetes Mellitus/terapia , Promoción de la Salud/organización & administración , Estilo de Vida Saludable , Población Rural , Anciano , Envejecimiento , Enfermedad Crónica , Dieta Saludable , Ejercicio Físico , Femenino , Humanos , Kentucky/epidemiología , Masculino , Persona de Mediana Edad , Salud Pública , Cese del Hábito de Fumar/métodos
2.
Cancer ; 124(2): 398-405, 2018 01 15.
Artículo en Inglés | MEDLINE | ID: mdl-29149503

RESUMEN

BACKGROUND: Cancer-related sexual dysfunction has been reported among adolescents and young adults (AYAs); however, its prevalence over time has not been examined. This longitudinal study investigated sexual dysfunction in AYAs over the course of 2 years after the initial diagnosis. METHODS: Young adult patients (18-39 years old) completed the Medical Outcomes Study Sexual Functioning Scale within the first 4 months of their diagnosis (n = 123) and again 6 (n = 107) and 24 months later (n = 95). An ordered multinomial response model analyzed changes in the probability of reporting sexual dysfunction over time and the independent effects of demographic, clinical, and psychosocial variables. RESULTS: More than half of the participants reported sexual functioning to be problematic at each assessment. The probability of reporting sexual dysfunction increased over time (P < .01) and was greater for cancer patients who were female (P < .001), older (P < .01), married or in a committed relationship (P < .001), treated with chemotherapy (P < .05), and reporting comorbid psychological distress (P < .001) and lower social support (P < .05). For women, being in a relationship increased the likelihood of reporting sexual problems over time; for men, the likelihood of reporting sexual problems increased regardless of their relationship status. CONCLUSIONS: A substantial proportion of young adults report ongoing problems with sexual functioning in the first 2 years after their cancer diagnosis. These findings justify the need to evaluate and monitor sexual functioning throughout a continuum of care. Cancer 2018;124:398-405. © 2017 American Cancer Society.


Asunto(s)
Neoplasias/psicología , Conducta Sexual/psicología , Adolescente , Adulto , Femenino , Humanos , Estudios Longitudinales , Masculino , Probabilidad , Disfunciones Sexuales Fisiológicas/epidemiología , Disfunciones Sexuales Psicológicas/epidemiología , Adulto Joven
3.
J Psychosoc Oncol ; 35(3): 260-277, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28121244

RESUMEN

OBJECTIVE: Data from the Health and Retirement Study were used to test a conceptual model integrating stress and coping, conservation of resources, and life-course theories, to investigate predictors of depression symptoms over 8 years among a nationally representative sample of older adults aged 50-91 years. The main investigative questions were: (1) Do older adults with cancer have a different 8-year symptomatic depression trajectory than those without cancer? (2) Do the differences in life-course factors, internal, external, and health-related resources within and between older adults have a differential effect on 8-year symptomatic depression trajectories for individuals with and without a cancer diagnosis? METHODS: We used a two-level longitudinal panel design to test a multilevel growth model. We examined individual differences in depression symptoms between 2000 and 2008, and tested multiple potential predictors. All those with a first diagnosis of cancer in 1998-2000 were included in the study (n = 200) together with a representative subsample of all noncancer cases (n = 1,190). RESULTS: Significant two-way interaction effects were detected between having cancer and the absence of spouse/partner in the home, and cancer and lower life expectancy; each resulted in higher probabilities of depression. A significant three-way interaction effect was detected between cancer, gender, and social support; women with a cancer history and low social support had the highest probability of depression. CONCLUSION: Assessment and intervention in the "survivorship" phase of cancer should target older adults with higher levels of depression early in the cancer experience, those with no partner present in home, those with lower life expectancy, and women with low social support.


Asunto(s)
Depresión/psicología , Neoplasias/psicología , Sobrevivientes/psicología , Adaptación Psicológica , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Análisis Multinivel , Neoplasias/terapia , Apoyo Social , Estrés Psicológico/psicología , Sobrevivientes/estadística & datos numéricos
4.
J Cancer Educ ; 31(2): 358-65, 2016 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-25708910

RESUMEN

For students of the health care professions to succeed in today's health care environment, they must be prepared to collaborate with other professionals and practice on interdisciplinary teams. As most will care for patients with cancer, they must also understand the principles of palliative care and its integration into oncology. This article reports the success of one university's effort to design and implement an interdisciplinary curriculum teaching team-based palliative care in oncology which was mandatory for medical, nursing, social work, and chaplaincy students. Quantitative evaluation indicated that students made significant improvements related to palliative care knowledge and skills and readiness for interprofessional education. Qualitative feedback revealed that students appreciated the experiential aspects of the curriculum most, especially the opportunity to observe palliative teams at work and practice team-based skills with other learners. While there exist many obstacles to interprofessional education and hands-on learning, the value of such experiences to the learners justifies efforts to initiate and continue similar programs in the health sciences.


Asunto(s)
Educación de Pregrado en Medicina/métodos , Personal de Salud/educación , Comunicación Interdisciplinaria , Estudios Interdisciplinarios , Neoplasias/tratamiento farmacológico , Cuidados Paliativos , Grupo de Atención al Paciente , Curriculum , Femenino , Implementación de Plan de Salud , Humanos , Masculino , Oncología Médica , Neoplasias/patología , Competencia Profesional , Enseñanza
5.
J Aging Soc Policy ; 27(1): 63-86, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-25299060

RESUMEN

Diabetes is a serious global public health challenge. The cost for health services for diabetes care has increased 41% over the past 5 years. Despite escalating health expenditure, the United States continues to have higher rates of diabetes than many other developed countries. There is a need for health care reform in the United States not only in reducing health care costs but also in improving the quality of preventative care. This study presents the testing of a multilevel model investigating variables on the individual and state levels to develop a better understanding of the most important contextual pathways that can lead to providing older adults (50+) with type 2 diabetes with the recommended preventative quality care they require. The model was tested using a three-level repeated cross-sectional design with data from various existing data sources, using a national sample of 181,870 individuals aged 50 years and older. Results showed that differences in state health care systems contributed to inequitable access. Specifically, in a state where there was a higher percentage of adults 65 and older coupled with a shortage of health care professionals, the likelihood of receiving the recommended preventative quality care decreased. Also, older adults living in states with a higher percentage of people with diagnosed diabetes but with a lower-than-average annual per capita health care expenditure fared worse in receiving quality preventative care. Last, older adults in wealthy states with higher percentages of uninsured people had the lowest odds of receiving quality preventative care. Health care reform, similar to what is currently promoted by the Patient Protection and Affordable Care Act of 2010, is recommended to improve the performance of all health care systems in all states.


Asunto(s)
Diabetes Mellitus Tipo 2 , Gastos en Salud , Accesibilidad a los Servicios de Salud , Servicios Preventivos de Salud/estadística & datos numéricos , Gobierno Estatal , Anciano , Anciano de 80 o más Años , Estudios Transversales , Diabetes Mellitus Tipo 2/prevención & control , Diabetes Mellitus Tipo 2/terapia , Conductas Relacionadas con la Salud , Reforma de la Atención de Salud/economía , Humanos , Pacientes no Asegurados , Persona de Mediana Edad , Vigilancia de la Población/métodos
6.
Gerontologist ; 64(7)2024 07 01.
Artículo en Inglés | MEDLINE | ID: mdl-38721939

RESUMEN

BACKGROUND AND OBJECTIVES: This study validates the Flourish Index-Revised (FI-R), a tool evaluating integrated healthcare models. The original Flourish Index (FI) was developed in 2018 and has been refined to align with the FlourishCare (FC) Model (Model) for geriatric primary care. RESEARCH DESIGN AND METHODS: The Model provides integrated biopsychosocial healthcare to older adults. The FI-R uses 25 quality-of-care indicators and 7 contextual community indicators. The FI-R was validated with Categorial Principal Components Analysis (CATPCA) using a sample of 949 patients 50+ who were mostly female (73%), non-Hispanic White (70%), living in urban areas (90%), and married (29%), single (22%), or divorced (19%). The mean age was 73.46 (standard deviation [SD] = 10.86) and mean years of education was 14.30 (SD = 2.14). RESULTS: CATPCA showed a 4-dimensional structure of biological, psychological, and 2 social determinants of health (SDOH) subdomains: health behaviors and community. Final selection of indicators was based on total variance accounted for >0.30, absolute values of item loadings >0.45, and not having cross-loadings >0.45 on 2 factors. Internal consistency (Cronbach's alpha) for the determinants were biological = 0.75, psychological = 0.76, SDOH:community = 0.70, SDOH:health behaviors = 0.50, and total FI-R = 0.95. Sensitivity to change was shown for the total FI-R, psychological determinants, and SDOH:health behaviors, but not for biological determinants. DISCUSSION AND IMPLICATIONS: The validation of the FI-R shows promise for its usability to evaluate integrated healthcare models using existing measures in electronic health systems. More work is needed to improve the incorporation of SDOH:sociodemographics into the FI-R.


Asunto(s)
Prestación Integrada de Atención de Salud , Atención Primaria de Salud , Humanos , Femenino , Masculino , Anciano , Persona de Mediana Edad , Anciano de 80 o más Años , Reproducibilidad de los Resultados , Indicadores de Calidad de la Atención de Salud , Análisis de Componente Principal
7.
J Am Geriatr Soc ; 72 Suppl 3: S6-S13, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38749954

RESUMEN

BACKGROUND: Use of the Project ECHO® (Extension for Community Healthcare Outcomes) model in geriatrics has increased dramatically largely because of the Health Resources and Services Administration-funded Geriatrics Workforce Enhancement Programs (GWEP) utilizing it as a key tool for age-friendly, interprofessional workforce development. This manuscript describes the scope and impact of geriatrics ECHOs under the GWEP. METHODS: A survey of GWEPs was conducted to measure the reach, foci, evaluation methods, and other characteristics of ECHO networks. RESULTS: All 48 (100%) GWEPs responded to the survey, and 30 (63%) reported using ECHO. GWEP ECHOs have both rural and urban-underserved reach across the United States, and their hub teams include many health professions. Age-friendly care is incorporated through multiple methods and is taught across foci including primary care, dementia, long term care, and novel topics. GWEP ECHOs have many academic and community partners including Area Agencies on Aging, and reach varied health professions, trainees, and caregivers. Geriatrics ECHOs collect outcomes across the evidence continuum including the community-level outcome of Age-Friendly Health System designation. CONCLUSIONS: The ECHO model has been widely adopted by GWEPs as a key approach for workforce training in age-friendly care. Project ECHO is a valuable tool to expand interprofessional training for the geriatrics workforce, particularly for interprofessional teams in rural and underserved areas.


Asunto(s)
Geriatría , Humanos , Geriatría/educación , Estados Unidos , Anciano , Servicios de Salud para Ancianos , Fuerza Laboral en Salud , Evaluación de Programas y Proyectos de Salud , Servicios de Salud Comunitaria/organización & administración , Encuestas y Cuestionarios
8.
Artículo en Inglés | MEDLINE | ID: mdl-22424383

RESUMEN

The purpose of this phenomenological exploration was to describe the lived experiences of persons diagnosed with advanced cancer who receive Medicaid. Themes emerged from the transcribed interviews of 10 participants in accordance with the cancer trajectory. Before diagnosis, participants were uninsured or underinsured and had more severe symptoms prior to late diagnosis. Upon diagnosis, they desired hopeful, respectful communication and experienced strong emotional reactions. There was also an abrupt change in the use of health care resources. During cancer treatment, they experienced social isolation from family and friends while receiving strong psychosocial support from the health care team. Throughout the cancer trajectory, they focused on living, reclaiming normalcy, and expressed resiliency and spirituality. Findings support the need to recognize the "fighting spirit" of patients regardless of prognosis or socioeconomic status; the impact of hopeful, respectful communication; and the value of oncology social work assistance when navigating the cancer experience. Lack of health care coverage prior to severe symptoms prevented earlier diagnosis and contributed to poor physical outcomes. Medicaid eligibility enabled these patients to receive quality health care and focus on living beyond cancer.


Asunto(s)
Medicaid , Neoplasias/psicología , Adulto , Atención a la Salud/estadística & datos numéricos , Femenino , Humanos , Masculino , Pacientes no Asegurados/psicología , Persona de Mediana Edad , Neoplasias/diagnóstico , Neoplasias/terapia , Aislamiento Social , Apoyo Social , Espiritualidad , Estados Unidos , Adulto Joven
9.
Gerontol Geriatr Med ; 8: 23337214221122523, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36090315

RESUMEN

Background: The COVID-19 pandemic disproportionately affected populations served by Federally Qualified Health Centers (FQHCs), with high morbidity and mortality rates in ethnic minority older adults. In response to this pandemic, academic geriatric medicine teams through federally funded Geriatric Workforce Enhancement Program (GWEP) with FQHC partnership implemented new initiatives to improve the care for vulnerable older adults. Objectives: To describe how four FQHC/GWEP teams collaborated in caring for diverse communities of older adults during the pandemic. Methods: Four GWEPs have addressed pandemic response efforts with their respective FQHC partners. These collaborations to meet the increasing numbers of older adults seeking services, and the rising disparities exacerbated during the pandemic are delineated. Results: FQHC/GWEP partnerships enabled access to care, whether in-person or virtually to serve unmet needs of underserved older adults during the pandemic. Partnerships promoted COVID-19 education, testing, and vaccinations. Most FQHCs faced severe staffing shortages, and the digital divide challenged patients with barriers. GWEPs provided direct care, created educational materials, and developed telehealth programs. These partnerships addressed social determinants of health gaps caused by the pandemic. Conclusion: The findings demonstrate that strong partnerships between GWEPs and FQHCs mitigate health inequities for vulnerable ethnic minority and rural older adults during pandemic crises.

11.
J Gerontol Soc Work ; 54(2): 189-202, 2011 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21240716

RESUMEN

Social workers are often the key link between older adults, their families and community-based services. Thus, knowledge about older adults and community-based care is imperative for social work practice. Evaluation data are provided on a national multisite effort (N = 353) from 35 schools to assure graduate social work student's competency related to community services for older adults. Results suggest that the educational model as described in this article sets forth positive outcomes in the education of aging savvy social workers. Ongoing social work education is needed to meet the burgeoning needs of the geriatric population.


Asunto(s)
Servicios de Salud Comunitaria , Conocimientos, Actitudes y Práctica en Salud , Modelos Educacionales , Servicio Social/educación , Adulto , Anciano , Femenino , Enfermería Geriátrica , Humanos , Masculino , Persona de Mediana Edad , Estudiantes , Encuestas y Cuestionarios , Estados Unidos , Adulto Joven
12.
J Am Geriatr Soc ; 68(5): 1007-1014, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-31916246

RESUMEN

OBJECTIVES: To define the current incidence, epidemiology, and mortality of older adult patients hospitalized with community-acquired pneumonia (CAP) in Louisville, KY and thus estimate the burden of CAP in the older adult population of the United States. To define risk factors associated with early and late outcomes. DESIGN: This was a secondary analysis of older adults (aged ≥65 years) from the University of Louisville Pneumonia Study, a prospective population-based cohort study of all hospitalized adults with CAP between June 1, 2014, and May 31, 2016. SETTING: The study took place in all nine acute care hospitals for adults in Louisville, KY. PARTICIPANTS: Residents in the city of Louisville, KY, who were diagnosed with CAP between the inclusion dates were included and who were aged 65 years or older. MEASUREMENTS: Incidence of CAP and outcomes were measured. A total of nine risk factors were also assessed for any potential association with time to clinical stability, length of stay (LOS), and mortality. RESULTS: During the 2-year study, from a Louisville population of 102 264 adults aged 65 years or older, 4760 were hospitalized with CAP. The incidence of older adults hospitalized with CAP was 2093 per 100 000 population. This corresponds to 967 470 older adults in the United States hospitalized per year with CAP. The median time to clinical stability was 2 days, and the median LOS was 6 days. The 30-day all-cause mortality was 17%. The 1-year all-cause mortality was 38% (829 patients), which corresponds to 361 982 deaths in the United States with CAP in older adults. CONCLUSION: The estimated burden of CAP in older adults is substantial in the United States. Nearly 1 million older adults are hospitalized for CAP, and over a third of those die within 1 year. J Am Geriatr Soc 68:1007-1014, 2020.


Asunto(s)
Infecciones Comunitarias Adquiridas/mortalidad , Tiempo de Internación/estadística & datos numéricos , Neumonía/mortalidad , Anciano , Anciano de 80 o más Años , Comorbilidad , Femenino , Humanos , Incidencia , Masculino , Estudios Prospectivos , Índice de Severidad de la Enfermedad , Estados Unidos/epidemiología
13.
Gerontol Geriatr Educ ; 30(3): 187-204, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-19697183

RESUMEN

With focus on interdisciplinary education models, social work and physical therapy faculty from two proximate universities partnered to create an evidence-based geriatric assessment and brief intervention research, training, and service project for community-dwelling older adults. Assessment tools and interventions were selected from the literature to develop the service protocols. These selected protocol skills were taught to interdisciplinary teams of students and professionals in social work and physical therapy, and learning outcomes were evaluated. This article describes the process of implementing this innovative multipartner project, the obstacles faced, and lessons learned. Adult learning theory and social cognitive theory served to underpin the project. The objectives were achieved, and evaluation noted many positive experiences in training and service delivery. This multipartner, interdisciplinary project concept can be replicated to improve educational outcomes for students and professionals as they prepare and learn to serve community-dwelling older adults.


Asunto(s)
Difusión de Innovaciones , Medicina Basada en la Evidencia , Evaluación Geriátrica , Servicios de Salud para Ancianos , Grupo de Atención al Paciente , Especialidad de Fisioterapia , Servicio Social , Adulto , Anciano , Anciano de 80 o más Años , Evaluación Educacional , Escolaridad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Modelos Educacionales , Satisfacción del Paciente , Autocuidado , Encuestas y Cuestionarios , Telemedicina
14.
Gerontologist ; 59(6): e653-e663, 2019 11 16.
Artículo en Inglés | MEDLINE | ID: mdl-30239756

RESUMEN

BACKGROUND AND OBJECTIVES: In evaluating integrated care models, traditional quality measures do not account for functional and quality of life factors, affecting older adults with multiple chronic conditions. The objective of this study was the development and validation of the Flourish Index (FI), an instrument to evaluate integrated care, using a determinants of health model. RESEARCH DESIGN AND METHODS: The study took place within the evaluation study of the Flourish Model (FM). The FM provides care coordination services using an integrated primary care and community-based services model. Baseline data from 70 older adults were used in the validation study. Twenty-seven quality of care indicators within six determinants of health, namely biological, psychological, individual health behaviors, health services, environmental, and social, formed part of the FI. RESULTS: Categorical principal components analysis showed a 5-dimensional structure with psychological determinants loading on the biological determinants of health. Internal consistency (Cronbach's alpha) for the determinants was as follows: biological/psychological = 0.73, individual = 0.58, environmental = 0.62, health services = 0.65, social = 0.67, total score = 0.97. Sensitivity to change was shown for the total FI score (F1,22 = 8.82, p = .01) and social (F1,22 = 5.82, p = .02), with a trend toward sensitivity for individual health behaviors (F1,22 = 3.95, p = .06) and health services (F1,22 = 3.26, p = .09). DISCUSSION AND IMPLICATIONS: The preliminary analysis of the FI shows promise for the usability of the index to provide insight into the fundamental challenges of aging. It brings greater clarity in caring for older adults and supports quality evaluation of integrated care coordination models.


Asunto(s)
Prestación Integrada de Atención de Salud , Garantía de la Calidad de Atención de Salud/métodos , Calidad de la Atención de Salud/organización & administración , Anciano , Servicios de Salud Comunitaria/organización & administración , Servicios de Salud Comunitaria/normas , Femenino , Estado de Salud , Humanos , Masculino , Modelos Organizacionales , Atención Primaria de Salud/organización & administración , Atención Primaria de Salud/normas , Garantía de la Calidad de Atención de Salud/normas , Indicadores de Calidad de la Atención de Salud , Calidad de la Atención de Salud/estadística & datos numéricos , Factores de Riesgo
16.
J Support Oncol ; 6(4): 183-92, 2008 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-18491687

RESUMEN

Socioeconomic factors substantially impact the quality of life (QOL) of persons diagnosed with cancer, yet socioeconomic well-being seldom is included as an essential domain when overall QOL is measured. This study details the development and psychometric analysis of a scale for measuring socioeconomic well-being in persons diagnosed with cancer. Coleman's theory of social class was used to define and develop the construct. The resulting scale consisting of two subscales--Material and Social Capital-demonstrated acceptable reliability, content and construct validity at both scale and item levels, and acceptable discriminant, convergent, and incremental validity.


Asunto(s)
Neoplasias/psicología , Calidad de Vida , Factores Socioeconómicos , Sobrevivientes/psicología , Estudios Transversales , Indicadores de Salud , Humanos , Masculino , Persona de Mediana Edad , Neoplasias/economía , Neoplasias/terapia , Psicometría , Análisis de Regresión , Proyectos de Investigación , Encuestas y Cuestionarios
17.
Adv Med Educ Pract ; 9: 109-118, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29497345

RESUMEN

A fragmented workforce consisting of multiple disciplines with varying levels of training and limited ability to work as a team often provides care to older adults. Interprofessional education (IPE) is essential for preparing practitioners for the effective teamwork required for community-based, holistic, person-centered care of the older adults. Despite numerous programs and offerings to advance education and interdisciplinary patient care, there is an unmet need for geriatric IPE, especially as it relates to community-dwelling older adults and caregivers in medically underserved areas. A core group of university faculty from multiple disciplines received funding from the Health Resources and Services Administration Geriatric Workforce Enhancement Program to collaborate with community-based providers from several Area Agencies on Aging in the creation and implementation of the Interprofessional Curriculum for the Care of Older Adults (iCCOA). This geriatric curriculum is interprofessional, comprehensive, and community-based. Learners include third-year nursing students, nurse practitioner students, third-year medical students, internal medicine and family medicine residents, master's level social work students, third-year pharmacy students, pharmacy residents, third-year dental students, dental hygiene students, community-based organization professionals, practicing community organizers, and community health navigators. This article describes the efforts, successes, and challenges experienced with this endeavor, including securing funding, ensuring equal representation of the disciplines, adding new components to already crowded curricula, building curriculum on best practices, improving faculty expertise in IPE, managing logistics, and ensuring comprehensive evaluation. The results summarize the iCCOA components, as well as the interprofessional domains, knowledge, and competencies.

18.
Circ Res ; 93(9): e98-103, 2003 Oct 31.
Artículo en Inglés | MEDLINE | ID: mdl-14551237

RESUMEN

Treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) decreases cardiovascular event rates in hypercholesterolemic patients. Whether statins exert effects within 24 hours on the coronary vasculature in patients with endothelial dysfunction has not been elucidated. Twenty-seven patients with stable angina pectoris and average low-density lipoprotein cholesterol concentrations of 138+/-9 mg/dL at baseline were allocated to treatment with placebo (14 patients) or 40 mg/d pravastatin (13 patients) in a randomized, double-blind, prospective trial. Coronary endothelial function was assessed before and 24 hours after single treatment by quantitative coronary angiography during intracoronary infusion of nitroglycerin or increasing concentrations of acetylcholine (0.01, 0.1, and 1 micromol/L). Coronary blood flow reserve was measured by Doppler velocimetry during adenosine infusion. Intracoronary acetylcholine infusion induced abnormal vasoconstriction in both groups before treatment, indicating coronary endothelial dysfunction. Treatment with a single oral 40-mg dose of pravastatin significantly attenuated acetylcholine-mediated vasoconstriction after 24 hours (mean+/-SE decrease in luminal diameter before and after treatment: 0.01 micromol/L, 6.1+/-2.2% versus 3.0+/-1.2%; 0.1 micromol/L, 15.6+/-2.6% versus 7.4+/-1.8%; P<0.05; 1 micromol/L, 22.9+/-2.9% versus 13.2+/-2.6%; P<0.05). There was no significant difference in the response to acetylcholine in the placebo group (8.1+/-2.4% versus 9.7+/-2.4%, 16.1+/-2.9% versus 16.8+/-3.2%, and 21.4+/-3.9% versus 23.3+/-4.2%). The response to nitroglycerin infusion was not altered in both groups. Increase in coronary blood flow in response to adenosine and coronary flow reserve remained unchanged during placebo and statin treatment. Serum concentrations of blood lipids and high-sensitive C-reactive protein were not significantly altered after 24 hours in response to placebo or pravastatin therapy. Statin treatment improves endothelium-dependent coronary vasomotion within 24 hours in the absence of significant cholesterol reduction. The full text of this article is available online at http://www.circresaha.org.


Asunto(s)
Angina de Pecho/tratamiento farmacológico , Vasos Coronarios/efectos de los fármacos , Endotelio Vascular/efectos de los fármacos , Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico , Pravastatina/uso terapéutico , Anciano , Angina de Pecho/enzimología , Angina de Pecho/fisiopatología , Velocidad del Flujo Sanguíneo/efectos de los fármacos , Presión Sanguínea/efectos de los fármacos , Proteína C-Reactiva/análisis , Angiografía Coronaria , Circulación Coronaria/efectos de los fármacos , Vasos Coronarios/fisiopatología , Método Doble Ciego , Endotelio Vascular/fisiopatología , Femenino , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Hidroximetilglutaril-CoA Reductasas/efectos de los fármacos , Hidroximetilglutaril-CoA Reductasas/metabolismo , Lípidos/sangre , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Factores de Tiempo , Grado de Desobstrucción Vascular/efectos de los fármacos , Vasodilatación/efectos de los fármacos , Vasodilatadores/farmacología
19.
J Appl Gerontol ; 34(2): 199-218, 2015 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-24652892

RESUMEN

This article provides the results of a photovoice project conducted with older adults affected by diabetes living in three rural counties in the southern region of the United States. Photovoice is a community-based participatory action methodology that puts the tools of research in the hands of participants. This project was an initial community engagement activity that promoted trust-building and formed part of a larger comprehensive community needs assessment. The process revealed themes of personal and community resilience focused on the daily living with diabetes, formal and informal supports, barriers to taking care of their diabetes, accessibility to fruits and vegetables, changes to food preparation and consumption, and exercise supports and barriers. The impact of the photovoice project on the participants and the implications for practice are discussed.


Asunto(s)
Investigación Participativa Basada en la Comunidad/métodos , Diabetes Mellitus/epidemiología , Población Rural/estadística & datos numéricos , Actividades Cotidianas , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Evaluación de Necesidades , Fotograbar , Características de la Residencia , Estados Unidos
20.
Am J Cardiol ; 93(1): 84-8, 2004 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-14697473

RESUMEN

The effect of 6-week treatment with 80 mg/day atorvastatin on vascular function in the forearm was investigated in 18 patients with mean pretreatment serum low-density lipoprotein cholesterol concentrations of 112 +/- 4 mg/dl in a double-blind, placebo-controlled, randomized study. Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation.


Asunto(s)
Anticolesterolemiantes/farmacología , Arteria Braquial/efectos de los fármacos , LDL-Colesterol/sangre , Antebrazo/irrigación sanguínea , Ácidos Heptanoicos/farmacología , Hipercolesterolemia/fisiopatología , Pirroles/farmacología , Administración Oral , Anticolesterolemiantes/administración & dosificación , Anticolesterolemiantes/uso terapéutico , Atorvastatina , Velocidad del Flujo Sanguíneo/efectos de los fármacos , Arteria Braquial/fisiología , Colesterol/sangre , HDL-Colesterol/sangre , Método Doble Ciego , Esquema de Medicación , Endotelio Vascular/efectos de los fármacos , Endotelio Vascular/fisiología , Femenino , Ácidos Heptanoicos/administración & dosificación , Ácidos Heptanoicos/uso terapéutico , Humanos , Hipercolesterolemia/sangre , Hipercolesterolemia/tratamiento farmacológico , Hiperemia/sangre , Hiperemia/tratamiento farmacológico , Hiperemia/fisiopatología , Masculino , Persona de Mediana Edad , Nitroglicerina/farmacología , Flujo Pulsátil/efectos de los fármacos , Pirroles/administración & dosificación , Pirroles/uso terapéutico , Resultado del Tratamiento , Triglicéridos/sangre , Vasodilatación/efectos de los fármacos , Vasodilatación/fisiología
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