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1.
PLoS Negl Trop Dis ; 12(1): e0006141, 2018 01.
Artículo en Inglés | MEDLINE | ID: mdl-29329311

RESUMEN

INTRODUCTION: Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess treatment effects. A sizable number of trials conducted over the years has generated only weak evidence backing current treatment recommendations, as shown by systematic reviews on old-world and new-world CL (OWCL and NWCL). MATERIALS AND METHODS: Using a previously published guidance paper on CL treatment trial methodology as the reference, consensus was sought on key parameters including core eligibility and outcome measures, among OWCL (7 countries, 10 trial sites) and NWCL (7 countries, 11 trial sites) during two separate meetings. RESULTS: Findings and level of consensus within and between OWCL and NWCL sites are presented and discussed. In addition, CL trial site characteristics and capacities are summarized. CONCLUSIONS: The consensus reached allows standardization of future clinical research across OWCL and NWCL sites. We encourage CL researchers to adopt and adapt as required the proposed parameters and outcomes in their future trials and provide feedback on their experience. The expertise afforded between the two sets of clinical sites provides the basis for a powerful consortium with potential for extensive, standardized assessment of interventions for CL and faster approval of candidate treatments.


Asunto(s)
Antiprotozoarios/uso terapéutico , Ensayos Clínicos como Asunto/normas , Leishmaniasis Cutánea/tratamiento farmacológico , Humanos , Resultado del Tratamiento
2.
Rev Iberoam Micol ; 24(2): 161-3, 2007 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-17604439

RESUMEN

A male patient with HIV and past history of tuberculosis and suspected neurotoxoplasmosis was admitted to the hospital with vomiting and small nodules through all his body. Few of the nodules were found forming chains of enlarged lymphatic vessels, especially on lesions located on the limbs. Some of the nodules were ulcerated with a serosanguineous discharge. Collected samples from ulcerated and the nodular lesions showed the presence of Sporothrix schenckii in culture. Although all hemocultures were negative, a spinal fluid collected from this patient and cultures from the cutaneous lesions were both positive for S. schenckii. The patient showed improvement after treatment with Amphotericin B. Sadly, he later died of complications not related to the S. schenckii infection. This case of disseminated sporotrichosis is a remainder that in patients with immunological disorders exotic forms of this fungal clinical entity could be expected.


Asunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/microbiología , Meningitis Fúngica/microbiología , Esporotricosis/etiología , Infecciones Oportunistas Relacionadas con el SIDA/diagnóstico , Infecciones Oportunistas Relacionadas con el SIDA/tratamiento farmacológico , Adulto , Anfotericina B/uso terapéutico , Antifúngicos/uso terapéutico , Candidiasis Bucal/complicaciones , Líquido Cefalorraquídeo/microbiología , Diagnóstico Diferencial , Resultado Fatal , Humanos , Masculino , Meningitis Fúngica/diagnóstico , Meningitis Fúngica/tratamiento farmacológico , Piel/microbiología , Esporotricosis/diagnóstico , Esporotricosis/tratamiento farmacológico , Toxoplasmosis Cerebral/diagnóstico
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