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1.

Biochemical and functional characterization of Plasmodium falciparum DNA polymerase Î´.

Vasuvat, Jitlada; Montree, Atcha; Moonsom, Sangduen; Leartsakulpanich, Ubolsree; Petmitr, Songsak; Focher, Federico; Wright, George E; Chavalitshewinkoon-Petmitr, Porntip.

Malar J ; 15: 116, 2016 Feb 24.

Artículo en Inglés | MEDLINE | ID: mdl-26911594

2.

Super-telomeres in transformed human fibroblasts.

Chiodi, Ilaria; Belgiovine, Cristina; Zongaro, Samantha; Ricotti, Roberta; Horard, Beatrice; Lossani, Andrea; Focher, Federico; Gilson, Eric; Giulotto, Elena; Mondello, Chiara.

Biochim Biophys Acta ; 1833(8): 1885-93, 2013 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-23570868

3.

Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.

Butini, Stefania; Gemma, Sandra; Brindisi, Margherita; Borrelli, Giuseppe; Fiorini, Isabella; Samuele, Alberta; Karytinos, Aristotele; Facchini, Marcella; Lossani, Andrea; Zanoli, Samantha; Campiani, Giuseppe; Novellino, Ettore; Focher, Federico; Maga, Giovanni.

Bioorg Med Chem Lett ; 21(13): 3935-8, 2011 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-21636271

4.

First dual AK/GSK-3ß inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents.

Brogi, Simone; Ramunno, Anna; Savi, Lida; Chemi, Giulia; Alfano, Gloria; Pecorelli, Alessandra; Pambianchi, Erika; Galatello, Paola; Compagnoni, Giulia; Focher, Federico; Biamonti, Giuseppe; Valacchi, Giuseppe; Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe; Brindisi, Margherita.

Eur J Med Chem ; 138: 438-457, 2017 Sep 29.

Artículo en Inglés | MEDLINE | ID: mdl-28689095

5.

Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.

Semeraro, Teresa; Lossani, Andrea; Botta, Maurizio; Ghiron, Chiara; Alvarez, Reinaldo; Manetti, Fabrizio; Mugnaini, Claudia; Valensin, Silvia; Focher, Federico; Corelli, Federico.

J Med Chem ; 49(20): 6037-45, 2006 Oct 05.

Artículo en Inglés | MEDLINE | ID: mdl-17004717

6.

The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.

Turriziani, Ombretta; Pagnotti, Paolo; Pierangeli, Alessandra; Focher, Federico; Baranello, Cinzia; Bellomi, Francesca; Falasca, Francesca; Morgan, Jessica; Schuetz, John D; Antonelli, Guido.

AIDS Res Hum Retroviruses ; 22(10): 960-7, 2006 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-17067265

7.

Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.

Savi, Lida; Brindisi, Margherita; Alfano, Gloria; Butini, Stefania; La Pietra, Valeria; Novellino, Ettore; Marinelli, Luciana; Lossani, Andrea; Focher, Federico; Cavella, Caterina; Campiani, Giuseppe; Gemma, Sandra.

Chem Biol Drug Des ; 87(1): 112-20, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-26242695

8.

Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.

Manikowski, Andrzej; Verri, Annalisa; Lossani, Andrea; Gebhardt, Bryan M; Gambino, Joseph; Focher, Federico; Spadari, Silvio; Wright, George E.

J Med Chem ; 48(11): 3919-29, 2005 Jun 02.

Artículo en Inglés | MEDLINE | ID: mdl-15916444

9.

Prodrugs of herpes simplex thymidine kinase inhibitors.

Yanachkova, Milka; Xu, Wei-Chu; Dvoskin, Sofya; Dix, Edward J; Yanachkov, Ivan B; Focher, Federico; Savi, Lida; Sanchez, M Dulfary; Foster, Timothy P; Wright, George E.

Antivir Chem Chemother ; 24(2): 47-55, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-26463822

10.

Selection of a T-cell line resistant to stavudine and zidovudine by prolonged treatment with stavudine.

Turriziani, Ombretta; Scagnolari, Carolina; Bambacioni, Federica; Bellomi, Francesca; Focher, Federico; Gentile, Massimo; Antonelli, Guido.

Antivir Ther ; 7(2): 105-11, 2002 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-12212922

11.

Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development.

Focher, Federico; Spadari, Silvio; Maga, Giovanni.

Curr Drug Targets Infect Disord ; 3(1): 41-53, 2003 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-12570732

12.

Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.

Roy, Béatrice; Verri, Annalisa; Lossani, Andrea; Spadari, Silvio; Focher, Federico; Aubertin, Anne-Marie; Gosselin, Gilles; Mathé, Christophe; Périgaud, Christian.

Biochem Pharmacol ; 68(4): 711-8, 2004 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-15276078

13.

Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity.

Manfredini, Stefano; Solaroli, Nicola; Angusti, Angela; Nalin, Federico; Durini, Elisa; Vertuani, Silvia; Pricl, Sabrina; Ferrone, Marco; Spadari, Silvio; Focher, Federico; Verri, Annalisa; De Clercq, Erik; Balzarini, Jan.

Antivir Chem Chemother ; 14(4): 183-94, 2003 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-14582847

14.

Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase.

Corelli, Federico; Botta, Maurizio; Lossani, Andrea; Pasquini, Serena; Spadari, Silvio; Focher, Federico.

Farmaco ; 59(12): 987-92, 2004 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-15598434

15.

N²-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases.

Lossani, Andrea; Savi, Lida; Manikowski, Andrzej; Maioli, Andrew; Gambino, Joseph; Focher, Federico; Spadari, Silvio; Wright, George E.

J Mol Biochem ; 1(1): 21-25, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-24734222

16.

Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds.

Torti, Andrea; Lossani, Andrea; Savi, Lida; Focher, Federico; Wright, George Edward; Brown, Neal Curtis; Xu, Wei-Chu.

Curr Enzym Inhib ; 7(3): 147-153, 2011 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-22844265

17.

Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

Butini, Stefania; Gemma, Sandra; Brindisi, Margherita; Borrelli, Giuseppe; Lossani, Andrea; Ponte, Anna Maria; Torti, Andrea; Maga, Giovanni; Marinelli, Luciana; La Pietra, Valeria; Fiorini, Isabella; Lamponi, Stefania; Campiani, Giuseppe; Zisterer, Daniela M; Nathwani, Seema-Maria; Sartini, Stefania; La Motta, Concettina; Da Settimo, Federico; Novellino, Ettore; Focher, Federico.

J Med Chem ; 54(5): 1401-20, 2011 Mar 10.

Artículo en Inglés | MEDLINE | ID: mdl-21319802

18.

Maupertuis: the 'old synthesis'.

Focher, Federico.

J Genet ; 93(2): 607-8, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-25189267

19.

Effect of combinations of antiviral drugs on herpes simplex encephalitis.

Gebhardt, Bryan M; Focher, Federico; Eberle, Richard; Manikowski, Andrzej; Wright, George E.

Drug Des Devel Ther ; 3: 289-94, 2009 Dec 29.

Artículo en Inglés | MEDLINE | ID: mdl-20054446

20.

Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.

Focher, Federico; Lossani, Andrea; Verri, Annalisa; Spadari, Silvio; Maioli, Andrew; Gambino, Joseph J; Wright, George E; Eberle, Richard; Black, Darla H; Medveczky, Peter; Medveczky, Maria; Shugar, David.

Antimicrob Agents Chemother ; 51(6): 2028-34, 2007 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-17438061

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