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1.
Accelerating robust plausible virtual patient cohort generation by substituting ODE simulations with parameter space mapping.
J Pharmacokinet Pharmacodyn
; 49(6): 625-644, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36316606
2.
Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies.
Lancet
; 396(10266): 1885-1894, 2020 12 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33308471
3.
Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment.
J Pharmacokinet Pharmacodyn
; 43(1): 29-43, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26578442
4.
Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment.
J Pharmacokinet Pharmacodyn
; 43(1): 13-27, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26563503
5.
Pharmacokinetic/Pharmacodynamic modeling of abexinostat-induced thrombocytopenia across different patient populations: application for the determination of the maximum tolerated doses in both lymphoma and solid tumour patients.
Invest New Drugs
; 32(5): 985-94, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24875134
6.
Quantitative systems pharmacology modeling of tumor heterogeneity in response to BH3-mimetics using virtual tumors calibrated with cell viability assays.
CPT Pharmacometrics Syst Pharmacol
; 2024 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38747730
7.
Application of hematological toxicity modeling in clinical development of abexinostat (S-78454, PCI-24781), a new histone deacetylase inhibitor.
Pharm Res
; 30(10): 2640-53, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23737346
8.
How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example.
Clin Pharmacol Ther
; 113(2): 310-320, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35355254
9.
Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia.
Cancer Res Commun
; 2(11): 1532-1544, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36970053
10.
Clinical Pharmacology and Determinants of Response to UCART19, an Allogeneic Anti-CD19 CAR-T Cell Product, in Adult B-cell Acute Lymphoblastic Leukemia.
Cancer Res Commun
; 2(11): 1520-1531, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36970059
11.
UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial.
Lancet Haematol
; 9(11): e833-e843, 2022 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-36228643
12.
Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach.
CPT Pharmacometrics Syst Pharmacol
; 10(11): 1396-1411, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34708556
13.
Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Clin Pharmacol Ther
; 109(3): 605-618, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32686076
14.
Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.
AAPS J
; 20(2): 39, 2018 03 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29516207
15.
Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.
AAPS J
; 20(3): 55, 2018 03 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-29589158
16.
Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity.
Clin Cancer Res
; 24(11): 2631-2641, 2018 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29463552
17.
Influence of the duration of intravenous drug administration on tumor uptake.
Front Oncol
; 3: 192, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23898461
18.
Pharmacokinetic/pharmacodynamic modelling-based optimisation of administration schedule for the histone deacetylase inhibitor abexinostat (S78454/PCI-24781) in phase I.
Eur J Cancer
; 49(13): 2791-7, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23790467
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