RESUMEN
Plasmacytoid blast dendritic cell neoplasia (NCDBP) is an uncommon malignant neoplasm, presenting clinically with cutaneous involvement and subsequent lymph node and bone marrow extension. It characteristically expresses the markers: CD56, CD4, and CD123. There is no optimal treatment, relapses are frequent, and the survival time is short. We present the case of an elderly patient with NCDBP who initially presented with cutaneous lesions, but experienced rapid systemic progression and did not, respond to treatment.
Asunto(s)
Células Dendríticas/patología , Neoplasias Glandulares y Epiteliales/patología , Neoplasias Cutáneas/patología , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Dorso , Ciclofosfamida/uso terapéutico , Progresión de la Enfermedad , Doxorrubicina/análogos & derivados , Doxorrubicina/uso terapéutico , Resultado Fatal , Humanos , Masculino , Neoplasias Glandulares y Epiteliales/diagnóstico , Neoplasias Glandulares y Epiteliales/tratamiento farmacológico , Prednisona/uso terapéutico , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/tratamiento farmacológico , Vincristina/uso terapéuticoRESUMEN
Papular acantholytic dermatosis of the vulva is a rare, chronic disorder and is an entity that remains to be fully understood. It shares clinical and histopathological overlap with Darier disease and Hailey-Hailey disease. We describe a 30-year-old woman with papular acantholytic dermatosis of the vulva. The lesions consisted of whitish papules and erosions on the labia majora. Histologically, there was hyperkeratosis and focal parakeratosis with acantholytic and dyskeratotic cells. She did not respond completely to topical steroids but clinical improvement occurred after the use of topical tacrolimus.
Asunto(s)
Acantólisis/tratamiento farmacológico , Inhibidores de la Calcineurina/administración & dosificación , Tacrolimus/administración & dosificación , Enfermedades de la Vulva/tratamiento farmacológico , Acantólisis/patología , Administración Tópica , Adulto , Femenino , Humanos , Enfermedades de la Vulva/patologíaRESUMEN
Psoriasis is a common inflammatory dermatosis that may be associated with a number of diseases. Recent studies provide evidence that there is a greater frequency of autoimmune diseases, but association with autoimmune connective tissue diseases is uncommon. The coexistence of psoriasis and lupus erythematosus is rare. Besides, the occurrence of morphea has rarely been reported in patients with lupus or psoriasis. We report a woman with cutaneous lupus and morphea profunda associated with psoriasis, with an excellent response to methotrexate, and review the literature.
Asunto(s)
Lupus Eritematoso Cutáneo/complicaciones , Psoriasis/complicaciones , Esclerodermia Localizada/complicaciones , Anciano , Femenino , HumanosRESUMEN
Heterotopic ossification is an uncommon disorder that consists of deposition of ectopic bone outside the extraskeletal tissues. In the skin, it can be primary, in association with genetic syndromes, or be secondary to different disorders. The latter include subcutaneous ossification of the legs in chronic venousinsufficiency, an infrequent and unrecognized complication. We report the case of a patient with subcutaneous ossification of both legs secondary to venous insufficiency and review the literature.
Asunto(s)
Pierna , Osificación Heterotópica/patología , Anciano , Humanos , MasculinoRESUMEN
We present the case of a 72-year-old Caucasian woman with frontal fibrosing alopecia of one year's duration. Eighteen months later, she presented with sudden hyperpigmentation on the submental area, neck and upper chest. Histopathological examination was consistent with lichen planus pigmentosus. This is the report of a unique case of a FFA and extrafacial lichen planus pigmentosus.
Asunto(s)
Alopecia/patología , Hiperpigmentación/patología , Liquen Plano/patología , Anciano , Alopecia/complicaciones , Dermoscopía , Femenino , Frente/patología , Humanos , Hiperpigmentación/complicaciones , Liquen Plano/complicaciones , Piel/patologíaAsunto(s)
Hidradenitis Supurativa/tratamiento farmacológico , Hidradenitis Supurativa/patología , Interferón-alfa/uso terapéutico , Micosis Fungoide/tratamiento farmacológico , Micosis Fungoide/patología , Anciano , Biopsia , Folículo Piloso/patología , Humanos , Inmunohistoquímica , Linfocitos/patología , MasculinoAsunto(s)
Angiofibroma/complicaciones , Dermatitis Atópica/complicaciones , Neoplasias Faciales/complicaciones , Neoplasias Cutáneas/complicaciones , Adulto , Angiofibroma/patología , Neoplasias Faciales/patología , Femenino , Humanos , Masculino , Índice de Severidad de la Enfermedad , Neoplasias Cutáneas/patologíaRESUMEN
Abstract We present the case of a 72-year-old Caucasian woman with frontal fibrosing alopecia of one year's duration. Eighteen months later, she presented with sudden hyperpigmentation on the submental area, neck and upper chest. Histopathological examination was consistent with lichen planus pigmentosus. This is the report of a unique case of a FFA and extrafacial lichen planus pigmentosus.